Brain Imaging Phenotypes Associated with Polygenic Risk for Essential Tremor
Abstract Essential tremor (ET) is a common movement disorder with a strong genetic basis. Magnetic resonance imaging (MRI), particularly diffusion‐weighted MRI (dMRI) and T1 MRI, have been used to identify brain abnormalities of ET patients. However, the mechanisms by which genetic risk affects the brain to render individuals vulnerable to ET remain ...
Miranda Medeiros+14 more
wiley +1 more source
How to run a brain bank. A report from the Austro-German brain bank [PDF]
The sophisticated analysis of and growing information on the human brain requires that acquisition, dissection, storage and distribution of rare material are managed in a professional way.
Gsell, W.+9 more
core
An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models [PDF]
Brain collateral circulation is an essential compensatory mechanism in response to acute brain ischemia. To study the temporal evolution of brain macro and microcollateral recruitment and their reciprocal interactions in response to different ischemic ...
Bentele, Kajetan+14 more
core +1 more source
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar+10 more
wiley +1 more source
Affective and cognitive prefrontal cortex projections to the lateral habenula in humans
Anterior insula (AI) and dACC are known to process information about pain, loss, adversities, bad, harmful or suboptimal choices and consequences that threaten survival or well-being.
Vadovičová, Karin
core +1 more source
Tourette syndrome research highlights 2015 [version 1; referees: 3 approved] [PDF]
We present selected highlights from research that appeared during 2015 on Tourette syndrome and other tic disorders. Topics include phenomenology, comorbidities, developmental course, genetics, animal models, neuroimaging, electrophysiology, pharmacology,
Black, Kevin J, Richards, Cheryl A
core +3 more sources
Corticospinal Tract Development, Evolution, and Skilled Movements
Abstract The evolution of the corticospinal tract (CST) is closely linked to the development of skilled voluntary movements in mammals. The main evolutionary divergence concerns the position of the CST within the spinal cord white matter and its postsynaptic targets in the grey matter.
Emmanuel Roze+2 more
wiley +1 more source
The Electron Microscope Study of the Corpus Striatum
The rat brain was fixed by OsO4 immersion after brief glutaraldehyde perfusion, and the caudate nucleus, the putamen and the globus pallidus were observed with the electron microscope.Numerous small cells (10-15μ) and a few large cells of two kinds (15-20μ) could be seen electron-microscopically in the neostriatum.
openaire +4 more sources
Caffeine. cognitive and physical performance enhancer or psychoactive drug? [PDF]
Caffeine use is increasing worldwide. The underlying motivations are mainly concentration and memory enhancement and physical performance improvement. Coffee and caffeine-containing products affect the cardiovascular system, with their positive inotropic
Aromatario, Mariarosaria+3 more
core +1 more source
Intermittent Fasting Enhances Motor Coordination Through Myelin Preservation in Aged Mice
Over a 10‐week regimen, IMF significantly improved locomotor activity, motor coordination, and muscle strength compared to controls (p < 0.01). Resting‐state fMRI (rsfMRI) demonstrated that IMF modulates brain‐wide functional connectivity, enhancing communication between key brain regions.
Zhuang Liu+12 more
wiley +1 more source