Results 61 to 70 of about 310,882 (171)

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Quantitative MRI Assessment of Gyrification and Brain Volume in Congenital Cytomegalovirus Fetuses and Postnatal Outcome

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective Quantitative assessment of the impact of cytomegalovirus (CMV) infection on fetal brain development beyond conventional imaging remains limited. We aimed to quantify cortical gyrification and brain volumes in CMV‐exposed fetuses, compare groups with varying severities of conventional MRI findings, and evaluate postnatal outcomes ...
Or R. Sadan, Bossmat Yehuda, Maya Yanko, Aaron Olender, Yair Wexler, Galia Grisaru‐Soen, Yael Leitner, Aviad Rabinowich, Bella Specktor‐Fadida, Dana Schonberger, Shira Ben Haim, Tal Zimels, Leo Joskowicz, Liat Ben Sira, Dafna Ben Bashat   +14 more
wiley   +1 more source

S158. URBANICITY INDEX AND CORTICAL GYRIFICATION IN SCHIZOPHRENIA [PDF]

Schizophr Bull, 2020
Abstract Background Urban birth and upbringing are considered to be risk factors for schizophrenia, but recent studies do not support the same. While several hypotheses are suggested, the pathogenic mechanisms are not known.
Korann V, Thonse U, Jacob A, Patil V, Shiri S, Devi P, Nagendra B, Kunte M, Shukla A, Padmanabha A, Vijay Kumar K, Varambally S, Venkatasubramanian G, Rao N.   +13 more
europepmc   +3 more sources

Associations of cannabis use, tobacco use and co‐use with brain volume: A systematic review and meta‐analysis

Addiction, EarlyView.
Abstract Background and aims Cannabis is the most widely used illicit drug worldwide and is often co‐used with tobacco, the leading cause of preventable death. Although cannabis and tobacco have distinct neurobiological actions, their associations with brain volumes are unclear.
Katherine Sawyer, Tom P. Freeman, Martine Skumlien, Esther Walton, Thomas Lancaster, Jorien L. Treur, Valentina Lorenzetti, Anna K. M. Blackwell, Chloe Burke, Richie J. Carr, Constantinos Constantinides, Maisie Cox, Sarah Dance, Shadi Daryan, Sorcha Hamilton, Tom Jenkins, Gemma M. J. Taylor   +16 more
wiley   +1 more source

Association between circadian sleep regulation and cortical gyrification in young and older adults. [PDF]

, 2023
The circadian system orchestrates sleep timing and structure and is altered with increasing age. Sleep propensity, and particularly REM sleep is under strong circadian control and has been suggested to play an important role in brain plasticity.
Taillard, Jacques, Reichert, Carolin F, Michele Deantoni, Berthomier, Christian, De Haan, Stella, Muto, Vincenzo, Marion Baillet, Reichert, Carolin, F, Micheline Maire, Christina Schmidt, Hammad, Gregory, Gregory Hammad, Christian Berthomier, Lambot, Eric, Christian Cajochen, Marine Dourte, Maire, Micheline, Eric Lambot, Schmidt, Christina, Vincenzo Muto, Stella De Haan, Mathilde Reyt, Jacques Taillard, Carolin F Reichert, Cajochen, Christian, Baillet, Marion, Dourte, Marine, Deantoni, Michele, Reyt, Mathilde, Muto, V   +29 more
core   +4 more sources

Annual Research Review: Sex differences in conduct disorder – revisiting existing evidence and exploring future directions

Journal of Child Psychology and Psychiatry, EarlyView.
Conduct disorder (CD) is a common psychiatric disorder in youth, characterized by severe and recurrent aggressive and antisocial behaviors and associated with substantial healthcare and societal costs. Rates of CD increase during adolescence in both sexes, with the male‐to‐female ratio narrowing to approximately 1:1.
Anka Bernhard, Christine M. Freitag, Kerstin Konrad, Lucres Jansen, Andreas G. Chiocchetti, Christina Stadler, Stephane A. De Brito, Graeme Fairchild, Gregor Kohls   +8 more
wiley   +1 more source

Cortical surface analysis for focal cortical dysplasia diagnosis by using PET images

Heliyon
Focal cortical dysplasia (FCD) is a neurological disorder distinguished by faulty brain cell structure and development. Repetitive and uncontrollable seizures may be linked to FCD's aberrant cortical thickness, gyrification, and sulcal depth ...
Eric Jacob Bacon, Chaoyang Jin, Dianning He, Shuaishuai Hu, Lanbo Wang, Han Li, Shouliang Qi   +6 more
doaj   +1 more source

Annual Research Review: A probe into sensitive periods – how the developmental timing of adverse childhood experiences influences brain structure and function – a systematic review

Journal of Child Psychology and Psychiatry, EarlyView.
It is proposed that adverse childhood experiences (ACEs) – potent predictors of mental illness – exert time‐dependent effects on neurodevelopment, reflecting periods of heightened neuroplasticity and developmental sensitivity. We systematically reviewed neuroimaging studies examining the role of timing in the association of ACE exposure with brain ...
Stephanie Hartanto, Divyangana Rakesh, Catherine Orr, Ebony Forlano, Muskan Khetan, Sarah Whittle   +5 more
wiley   +1 more source

Adolescent maturation of the relationship between cortical gyrification and cognitive ability [PDF]

NeuroImage, 2017
There are changes to the degree of cortical folding from gestation through adolescence into young adulthood. Recent evidence suggests that degree of cortical folding is linked to individual differences in general cognitive ability in healthy adults. However, it is not yet known whether age-related cortical folding changes are related to maturation of ...
Yu Sun Chung, Christopher J. Hyatt, Michael C. Stevens 0001   +2 more
openaire   +3 more sources