Results 121 to 130 of about 369,799 (284)
Advanced Science, EarlyView.Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang +14 more
wiley +1 more source
, 2011 Malformations of cortical development have been described in children and families with language-learning impairment. The objective of this study was to assess the auditory processing information in children with language-learning impairment in the ...
Cendes, Fernando +14 more
core +1 more source
Advanced Science, EarlyView.Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala +15 more
wiley +1 more source
Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling
Advanced Science, EarlyView.Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Fangzi Zha +13 more
wiley +1 more source
Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment
Advanced Science, EarlyView.Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang +9 more
wiley +1 more source
[Classification and pathogenesis of cerebral cortical malformations].
No to hattatsu = Brain and development, 1996 Cerebral cortical malformation is now diagnosed by neuroimagings, and important as a cause of developmental disorder or epilepsy. The classification of cortical malformations was tried from developmental aspect, and agyria in Miller-Dieker syndrome and polymicrogyria in Fukuyama-type congenital muscular dystrophy were compared on their pathogeneses ...
Takashima, Sachio +2 more
openaire +2 more sources
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source
, 2011 Context.—Angiocentric glioma is a rare, epilepsy-associated, low-grade neoplasm with a characteristic perivascular growth pattern. Objective.—To describe the clinicopathologic features of 5 angiocentric gliomas and to evaluate for ...
Richard Prayson, Trent Marburger
core +1 more source
TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains
Advanced Science, EarlyView.Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang +14 more
wiley +1 more source