Results 141 to 150 of about 1,085 (173)

Intestinal Mucin Glycosylation: Structural Regulation, Homeostasis Maintenance and Disease Association. [PDF]

Biomolecules
Li Y, Pan J, Liu H, Liu C.
europepmc   +1 more source

New Insights on IgA Nephropathy from the Perspective of Active Lesions and Systemic Inflammatory Responses. [PDF]

Immunotargets Ther
Yang Y, Xu G.
europepmc   +1 more source

Aberrant signaling in tonsillar B cells producing pathogenic <i>O</i>-glycoforms of IgA1 in IgA nephropathy. [PDF]

Front Immunol
Yamada K, Ogiwara K, Novak J, Suzuki Y.
europepmc   +1 more source

Hemocyte-secreted papilin bearing mucin-type <i>O</i>-glycans regulates peripodial stalk formation via epidermal JAK/STAT signaling in <i>Drosophila</i>. [PDF]

iScience
Fuwa TJ, Itoh K, Ichimiya T, Akimoto Y, Nishihara S.   +4 more
europepmc   +1 more source

GalNT2-mediated O-glycosylation affects pancreas development and function in mice. [PDF]

Sci Rep
Mercanoglu B, Waschkowski SA, Neuburg E, Schraps N, Giannou AD, Dreyer B, Harder S, Heine M, Krebs CF, Güngör C, Schlüter H, Melling N, Hackert T, Bockhorn M, Wagener C, Wolters-Eisfeld G.   +15 more
europepmc   +1 more source

Cosmc Regulates O-Glycan Extension in Murine Hepatocytes [PDF]

Glycobiology
Abstract Hepatocytes synthesize a vast number of glycoproteins found in their membranes and secretions, many of which contain O-glycans linked to Ser/Thr residues. As the functions and distribution of O-glycans on hepatocyte-derived membrane glycoproteins and blood glycoproteins are not well understood, we generated mice with a targeted ...
Rajindra P Aryal, Florian Erger, Richard D. Cummings   +2 more
exaly   +4 more sources

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COSMC expression as a predictor of remission in IgA nephropathy

International Urology and Nephrology, 2022
The impact of core 1,3-galactosyltransferase-specific molecular chaperon (COSMC) gene expression and methylation profile on clinical progression of IgA nephropathy (IgAN) is unclear. The aim of this study was to determine the clinical significance and the relation of the COSMC gene expression and methylation pattern with the progression of IgAN.Thirty ...
Sonay Temurhan, Fatma Savran Oguz, Yasemin Özlük   +2 more
exaly   +3 more sources

C1GALT1C1/COSMC is a novel prognostic biomarker for hepatocellular carcinoma

Clinics and Research in Hepatology and Gastroenterology, 2020
The aim of this study is to explore the effects of COSMC on the prognosis of hepatocellular carcinoma (HCC), and establish a novel model with improved predictive capacity.Ninety-two patients diagnosed with HCC from 2006 to 2010 in our hospital were recruited to analyze the correlation between COSMC expression and prognosis.
Yi-Fan Tong, Bo Shen, Yifan Wang
exaly   +3 more sources

Epigenetic Silencing of the Chaperone Cosmc in Human Leukocytes Expressing Tn Antigen* [PDF]

Journal of Biological Chemistry, 2012
Cosmc is the specific molecular chaperone in the endoplasmic reticulum for T-synthase, a Golgi β3-galactosyltransferase that generates the core 1 O-glycan, Galβ1-3GalNAcα-Ser/Thr, in glycoproteins. Dysfunctional Cosmc results in the formation of inactive T-synthase and consequent expression of the Tn antigen (GalNAcα1-Ser/Thr), which is associated with
Rajindra P Aryal, Tongzhong Ju, Richard D. Cummings   +2 more
exaly   +6 more sources

No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients. [PDF]

Nephrology Dialysis Transplantation, 2008
Altered IgA1 galactosylation is involved in the pathogenesis of IgA nephropathy (IgAN). The galactosyltransferase core-1 beta3-galactosyltransferase-1 (C1GALT1) and its chaperone cosmc are specifically required for O-galactosylation of the IgA1 hinge region.
Francesco P. Schena, Peter R Mertens, Jürgen Floege   +2 more
exaly   +5 more sources