Improved Messenger RNA Stability and Biocompatibility Through Self‐Gelatinizable Nucleic Acids
Biotechnology and Bioengineering, EarlyView.ABSTRACT Recent advances in the chemical synthesis and modification of messenger RNA (mRNA) have generated growing interest in mRNA‐based therapeutics. However, the inherent instability of mRNA in vivo and during storage remains a major challenge, requiring the development of safe and effective delivery systems.
Takumi Tanifuji +5 more
wiley +1 more source
The role of cytosine modification symmetry in mammalian epigenome regulation. [PDF]
Chem SciCakil ZV, Engelhard L, Summerer D.
europepmc +1 more source
BMEMat, EarlyView.The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang +7 more
wiley +1 more source
CpG islands identification in DNA sequences using modified P-spectrum based algorithm
, 2021 Pardeep Garg, Sunil Sharma
openalex +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Epigenetic Age Estimation for Hawaiian False Killer Whales (Pseudorca crassidens) in the Absence of 'Known-Age' Individuals. [PDF]
Mol Ecol ResourMartien KK +7 more
europepmc +1 more source
CpG Oligodeoxynucleotides Increase the Susceptibility of Normal Mice to Infection byCandida albicans
, 2005 Shuichi Ito +2 more
openalex +2 more sources
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, EarlyView.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Exploring the association between DNA methylation and pancreatic cancer susceptibility through epigenome-wide Mendelian randomization and multi-omics data integration. [PDF]
EpigeneticsWang P, Rong F, Liu F.
europepmc +1 more source