Building Civic Infrastructure: Implementing Community Partnership Grant Programmes in South Africa [PDF]
, 2002 This article examines recent efforts to establish Community Partnership Grant Programmes (CPG) in six South African communities. CPG programmes provide the financial and organizational infrastructure to support citizen-initiated neighbourhood ...
Charles F. Adams +2 more
core +1 more source
Efficacy of CpG-ODN Administration Routes on Humoral Responses against Newcastle disease in Broilers [PDF]
Archives of Razi Institute, 2019 Un-methylated cytosine-phosphate-guanosine oligodeoxynucleotides (CpG-ODN) has been considered as a powerful vaccine adjuvant and recognition of CpG-ODN by chicken leukocytes promotes their ability to fight against infections.
A. Talebi, S. Arky-rezai
doaj +1 more source
DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]
, 2018 Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario +9 more
core +2 more sources
Is inhaled immunotherapy more effective than environmental management when treating equine asthma?
Veterinary Evidence, 2021 PICO question In horses with severe equine asthma syndrome, is inhaled immunotherapy compared to environmental reduction of allergen exposure more effective in disease modification?
Amy Leather, Sarah Smith
doaj +1 more source
Structural basis for DNMT3A-mediated de novo DNA methylation. [PDF]
, 2018 DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at cytosines is essential for genome regulation and development. Dysregulation of this process is implicated in various diseases, notably cancer.
Chen, Dongliang +11 more
core +2 more sources
Prognostic significance of MGMT promoter methylation in diffuse glioma patients
Biotechnology & Biotechnological Equipment, 2019 Current treatment options for diffuse glioma patients include maximum safe resection followed by a combination of radiation therapy and chemotherapy with alkylating agents.
Nikola Jovanović +10 more
doaj +1 more source
OncoImmunology, 2020 Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we assessed the effects of local immune modulation in early-stage melanoma with CpG-B alone or with
Bas D. Koster +9 more
doaj +1 more source
KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]
, 2009 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny +4 more
core +1 more source
Human Vaccines & Immunotherapeutics, 2018 Cross-talk by pattern recognition receptors may facilitate the maturation of dendritic cells and fine tune the immune response. Thus, the inclusion of ligands agonistic to multiple receptors in a vaccine formula may be an effective strategy to elicit ...
Cunbao Liu +6 more
doaj +1 more source
Pathogenicity and virulence of hepatitis A virus
Virulence, 2021 Hepatitis A is an acute infection of the liver, which is mostly asymptomatic in children and increases the severity with age. Although in most patients the infection resolves completely, in a few of them it may follow a prolonged or relapsed course or ...
Rosa M Pintó +6 more
doaj +1 more source