Results 51 to 60 of about 370,062 (234)

Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

Nature Genetics, 2008
For the past 25 years, it has been known that alterations in DNA methylation (DNAm) occur in cancer, including hypomethylation of oncogenes and hypermethylation of tumor suppressor genes.
R. Irizarry, C. Ladd-Acosta, Bo Wen, Zhijin Wu, C. Montano, P. Onyango, H. Cui, Kevin Gabo, Michael A Rongione, M. Webster, Hong Ji, J. Potash, S. Sabunciyan, A. Feinberg   +13 more
semanticscholar   +1 more source

Exaggerated CpH methylation in the autism-affected brain. [PDF]

, 2017
BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E, Ellis, Shannon E, Gupta, Simone, Moes, Anna, West, Andrew B   +4 more
core   +1 more source

Coupling the neural and physical dynamics in rhythmic movements [PDF]

, 1996
A pair of coupled oscillators simulating a central pattern generator (CPG) interacting with a pendular limb were numerically integrated. The CPG was represented as a van der Pol oscillator and the pendular limb was modeled as a linearized, hybrid spring ...
Hatsopoulos, Nicholas G.
core   +1 more source

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]

, 2017
ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F, Cole, Michael, Criswell, Lindsey A, Firestein, Gary S, Graf, John, Halperin, Eran, Harrison, Ruby, Holingue, Calliope, Link, Thomas, Quach, Diana, Quach, Hong L, Rahmani, Elior, Rhead, Brooke, Shah, Khooshbu, Shao, Xiaorong, Sinclair, Elizabeth, Wang, Wei   +16 more
core   +1 more source

KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides

eLife, 2019
CpG dinucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication.
Mattia Ficarelli, H. Wilson, Rui Pedro Galão, Michela Mazzon, Irati Antzin-Anduetza, M. Marsh, S. Neil, Chad M. Swanson   +7 more
semanticscholar   +1 more source

Leveraging petrophysical and geological constraints for AI-driven predictions of total organic carbon (TOC) and hardness in unconventional reservoir prospects

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Key parameters for evaluating shale reservoirs include total organic carbon (TOC), thermal maturity, and hardness, the latter influencing fracture development and being crucial for managing ultralow permeability reservoirs.
Nandito Davy, Ammar El-Husseiny, Umair bin Waheed, Korhan Ayranci, Manzar Fawad, Mohamed Mahmoud, Nicholas B. Harris   +6 more
doaj   +1 more source

Estimation of fracture half-length with fast Gaussian pressure transient and RTA methods: Wolfcamp shale formation case study

Journal of Petroleum Exploration and Production Technology, 2023
Accurate estimation of fracture half-lengths in shale gas and oil reservoirs is critical for optimizing stimulation design, evaluating production potential, monitoring reservoir performance, and making informed economic decisions.
Ahmed Farid Ibrahim, Ruud Weijermars
doaj   +1 more source

Charge photogeneration in few-layer MoS2

, 2014
The two-dimensional semiconductor MoS2 in its mono- and few-layer form is expected to have a significant exciton binding energy of several 100 meV, leading to the consensus that excitons are the primary photoexcited species.
Arkhipov, Assael, Bauger, Britnell, Butler, Cabanillas-Gonzalez, Cheiwchanchamnangij, Coleman, Dean, Dhar, Evans, Fontana, Frindt, Gadermaier, Gadermaier, Gadermaier, Gatensby, Gutierrez, Hong, Ichibayashi, Klimov, Korn, Kozawa, Lagarde, Lee, Lee, Leitenstorfer, Li, Lopez-Sanchez, Mai, Mai, Mak, Mak, Manzoni, Mouri, Nicolosi, Noolandi, Osterbacka, Ouyang, Plechinger, Pospischil, Radisavljevic, Radisavljevic, Ramasubramaniam, Scheuschner, Schmitt-Rink, Sercombe, Shi, Sim, Sipos, Soavi, Splendiani, Stojchevska, Sun, Sun, Thomson, Tränkle, Ugeda, Wang, Wang, Wang, Yadgarov, Yan, Ye   +63 more
core   +1 more source

DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing [PDF]

, 2016
Comprehensive genome-wide DNA methylation studies in neuroblastoma (NB), a childhood tumor that originates from precursor cells of the sympathetic nervous system, are scarce. Recently, we profiled the DNA methylome of 102 well-annotated primary NB tumors
Decock, Anneleen, Ongenaert, Maté, Speleman, Franki, Van Criekinge, Wim, Vandesompele, Jo   +4 more
core   +1 more source

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function

Genes, 2017
DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC).
H. Jang, Woo Jung Shin, Jeong Eon Lee, J. Do   +3 more
semanticscholar   +1 more source