Results 51 to 60 of about 152,781 (323)
International Journal of Nanomedicine, 2022 Fenfen Gu,1,* Chuling Hu,2,* Wei Cao,3,* Chao Li,1 Qingming Xia,4 Yuan Gao,4 Yan Liu,1 Shen Gao1,4 1Department of Clinical Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of
Gu F +7 more
doaj
Human Vaccines & Immunotherapeutics, 2023 COVID-19 pandemic caused by SARS-CoV-2 infection has an impact on global public health and social economy. The emerging immune escape of SARS-CoV-2 variants pose great challenges to the development of vaccines based on original strains.
Feixia Gao +10 more
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Land-Streamer vs. Conventional Seismic Data for High-Resolution Near-Surface Surveys
Applied Sciences, 2022 Near-surface high-resolution seismic mapping is very important in many applications such as engineering and environmental. However, the conventional setup of the seismic technique requires planting geophones, connecting cables, and then collecting all ...
Sherif M. Hanafy
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Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs [PDF]
Gene Therapy, 2001 The unmethylated CpG motifs within E. coli DNA (EC) cause immune stimulation. In contrast, mammalian DNA such as calf thymus (CT) DNA had been thought to be immunologically inert. In this article, we demonstrate that CT DNA unexpectedly specifically inhibits the immune activation by EC but not that by endotoxin.
Michael J. McCluskie +9 more
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KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Advances in the pathogenesis of Rett syndrome using cell models
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022 Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley +1 more source
Energies, 2022 The present study shows how new Gaussian solutions of the pressure diffusion equation can be applied to model the pressure depletion of reservoirs produced with hydraulically multi-fractured well systems. Three practical application modes are discussed: (
Ruud Weijermars
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CPG-ACTOR: Reinforcement Learning for Central Pattern Generators [PDF]
arXiv, 2021 Central Pattern Generators (CPGs) have several properties desirable for locomotion: they generate smooth trajectories, are robust to perturbations and are simple to implement. Although conceptually promising, we argue that the full potential of CPGs has so far been limited by insufficient sensory-feedback information.
arxiv
In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases
PLoS Genetics, 2012 The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood. Here, we describe a comprehensive analysis of DNA methylation patterns generated by high resolution sequencing of hairpin-bisulfite amplicons of selected single copy genes and repetitive ...
Guoliang Xu +11 more
openaire +8 more sources
Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes [PDF]
Genome Research, 2010 Neutral nucleotide substitutions occur at varying rates along genomes, and it remains a major issue to unravel the mechanisms that cause these variations and to analyze their evolutionary consequences. Here, we study the role of replication in the neutral substitution pattern.
Chen, Chun-Long +10 more
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