Results 61 to 70 of about 152,781 (323)
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
The Journal of Experimental Medicine, 2007 Arthritis sufferers might get some therapeutic relief from bacterial nucleic acids that usually goad on inflammation, if results from Wu et al. (page 1911) are any indication. Some of these short CpG repeats (CpGs) are now shown to prevent arthritis progression in a mouse model.
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Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
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CpG oligodeoxynucleotides as mucosal adjuvants [PDF]
Human Vaccines & Immunotherapeutics, 2015 Bacterial DNA comprising palindromic sequences and containing unmethylated CpG is recognized by toll-like receptor 9 of plasmacytoid dendritic cells (pDCs) and induces the production of interferon-α and chemokines, leading to the activation of a Th1 immune response. Therefore, synthetic equivalents of bacterial DNA (CpG oligodeoxynucleotides) have been
Sumiko Iho +2 more
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Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Genome-wide CpG and non-CpG methylation regulation by CGGBP1
Canadian Journal of Biotechnology, 2017 DNA cytosine methylation occurs in all three sequence contexts: CpG and CHG (symmetrically on the two strands) and CHH (asymmetrically on one strand). While mechanisms of CpG methylation regulation are well studied; the non-CpG methylation is beginning to be understood.
Prasoon Agrawal +3 more
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Transcriptional repression by methylation of CpG [PDF]
Journal of Cell Science, 1992 ABSTRACT Methylated DNA in mammals is associated with transcriptional repression and nuclease resistant chromatin. In this review we discuss how these effects may be mediated by proteins that bind to methylated DNA.
Sally H. Cross +5 more
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FEBS Open Bio, EarlyView.Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel +4 more
wiley +1 more source
It's the CpG content that counts [PDF]
Nature Reviews Cancer, 2010 CpG content influences the mutation rate of surrounding DNA sequences, with increased CpG content correlating with an increased rate of transversions — a characteristic of 'mutator phenotypes' in some cancers.
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Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source