Results 71 to 80 of about 370,062 (234)

The Association of Methylation Level in the CYP39A1 Gene with High Altitude Pulmonary Edema in the Chinese Population

Pharmacogenomics and Personalized Medicine, 2023
Pingyi Wang,1– 3 Hongyan Lu,1– 3 Hao Rong,1– 3 Yuhe Wang,1– 4 Li Wang,1– 3 Xue He,1– 3 Dongya Yuan,1– 3 Yongjun He,1– 3 Tianbo Jin1– 3 1Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region ...
Wang P, Lu H, Rong H, Wang Y, Wang L, He X, Yuan D, He Y, Jin T   +8 more
doaj  

How much of the variation in the mutation rate along the human genome can be explained? [PDF]

, 2014
It has been claimed recently that it may be possible to predict the rate of de novo mutation of each site in the human genome with a high degree of accuracy [Michaelson et al. (2012), Cell 151: 143121442]. We show that this claim is unwarranted.
Eyre-Walker, Adam, Eyre-Walker, Ying Chen   +1 more
core   +1 more source

Detection of suspicious interactions of spiking covariates in methylation data [PDF]

, 2020
BACKGROUND: In methylation analyses like epigenome-wide association studies, a high amount of biomarkers is tested for an association between the measured continuous outcome and different covariates.
Kruppa, Jochen, Richter, Gesa, Schaefer, Arne S., Sieg, Miriam   +3 more
core   +1 more source

Nucleotide distance influences co-methylation between nearby CpG sites.

Genomics, 2019
The tendency of individual CpG sites to be methylated is distinctive, non-random and well-regulated throughout the genome. We investigated the structural and spatial factors influencing CpGs methylation by performing an ultra-deep targeted methylation ...
O. Affinito, Domenico Palumbo, A. Fierro, Mariella Cuomo, Giulia De Riso, A. Monticelli, G. Miele, L. Chiariotti, S. Cocozza   +8 more
semanticscholar   +1 more source

Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]

, 2015
We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi, Nakamoto, Masaru, Nakamura, Ritsuko, Namiki, Mikio, Ooi, Akishi, Oyama, Takeru, Tajiri, Ryosuke   +6 more
core   +1 more source

DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation Patterns.

Cancer Cell, 2019
Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion are subject to hypermethylation. Using methylome sequencing we identified CpG islands that display partial methylation encroachment across the 5' or 3' CpG island
Ksenia Skvortsova, Etienne Masle-Farquhar, Phuc-Loi Luu, Jenny Song, Wenjia Qu, E. Zotenko, Cathryn M. Gould, Q. Du, Timothy J. Peters, Yolanda Colino-Sanguino, R. Pidsley, Shalima Nair, Amanda Khoury, Grady C. Smith, L. Miosge, J. Reed, J. Kench, M. Rubin, L. Horvath, O. Bogdanović, S. Lim, J. Polo, C. Goodnow, C. Stirzaker, S. Clark   +24 more
semanticscholar   +1 more source

A new approach to medical rehabilitation and palliative care for patients with oncology in the context of integrative medicine

Актуальные проблемы теоретической и клинической медицины
The systematic review summarizes modern studies of the effect of plant phenols and certain drugs on the intracellular biochemical cascade in the formation of anti-cancer immunity.
S. A. Panov, N. T. Baltabekov, A. V. Pavlyukov, A. A. Paltushev, B. E. Nurgaliev, A. V. Rysbaev   +5 more
doaj   +1 more source

CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms

Journal of Virology, 2019
Some RNA virus genomes are suppressed in the nucleotide combination of a cytosine followed by a guanosine (CpG), indicating that they are detrimental to the virus.
Mattia Ficarelli, Irati Antzin-Anduetza, Rupert Hugh-White, A. Firth, Helin Sertkaya, H. Wilson, S. Neil, R. Schulz, Chad M. Swanson   +8 more
semanticscholar   +1 more source

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]

, 2019
BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker, Beach, Beamer, Best, Cardenas, Chhabra, Cunningham, DiFranza, Galanter, Gibbs, Gilliland, Gilliland, Gilliland, Hanieh, Harb, Hu, Jaakkola, Jauniaux, Joubert, Joubert, Küpers, Lara, Morales, Oh, Perreira, Pickett, Rahmani, Reese, Reese, Rehan, Richiardi, Richmond, Richmond, Sharma, Shorey-Kendrick, Stick, Stocks, Tong, Upton, van der Laan, Vanderweele, VanderWeele, Waterland, Wongtrakool, Wu, Zeilinger, Zhang, Zhong   +47 more
core   +1 more source

CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine

Drug Design, Development and Therapy, 2021
Qin Li,1,* Jie Ren,2,* Wei Liu,3 Guoqin Jiang,2 Rongkuan Hu1 1GenePharma Co., Ltd., Suzhou, 215125, Jiangsu, People’s Republic of China; 2Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004,
Li Q, Ren J, Liu W, Jiang G, Hu R
doaj