Results 91 to 100 of about 869,007 (330)

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection

Biochemical Society Transactions, 2013
Vertebrate DNA can be chemically modified by methylation of the 5 position of the cytosine base in the context of CpG dinucleotides. This modification creates a binding site for MBD (methyl-CpG-binding domain) proteins which target chromatin-modifying ...
H. K. Long, Neil P. Blackledge, R. Klose
semanticscholar   +1 more source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Multiple chaotic central pattern generators with learning for legged locomotion and malfunction compensation [PDF]

, 2014
An originally chaotic system can be controlled into various periodic dynamics. When it is implemented into a legged robot's locomotion control as a central pattern generator (CPG), sophisticated gait patterns arise so that the robot can perform various walking behaviors.
arxiv   +1 more source

Mining and Predicting CpG islands [PDF]

2007 IEEE International Fuzzy Systems Conference, 2007
A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucleotides are called dinucleotides and CpG islands represent regions of a DNA sequence, certain substrings, which are enriched in CpG dinucleotides (C followed by G).
Oscar Harari, C. del Val, Christopher Previti   +2 more
openaire   +2 more sources

Spreadsheet-Based Program for the Analysis of DNA Methylation

BioTechniques, 2001
Methylation of DNA in CpG dense regions of gene promoters (CpG islands) is important for transcriptional inactivation of selective genes in normal and neoplastic cells.
Ramaswamy Anbazhagan, James G. Herman, Kalyan Enika, Edward Gabrielson   +3 more
doaj   +1 more source

Integrating Contact-aware Feedback CPG System for Learning-based Soft Snake Robot Locomotion Controllers [PDF]

arXiv, 2023
This paper aims to solve the contact-aware locomotion problem of a soft snake robot by developing bio-inspired contact-aware locomotion controllers. To provide effective contact information for the controllers, we develop a scale-covered sensor structure mimicking natural snakes' scale sensilla.
arxiv  

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

eLife, 2012
CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs act as polycomb response elements (PREs) and are recognized by the polycomb silencing systems to regulate expression of genes involved in early development.
A. Farcas, Neil P. Blackledge, I. Sudbery, H. K. Long, J. McGouran, N. R. Rose, Sheena Lee, D. Sims, A. Cerase, Thomas W. Sheahan, H. Koseki, N. Brockdorff, C. Ponting, B. Kessler, R. Klose   +14 more
semanticscholar   +1 more source

Distribution of DNA methylation, CpGs, and CpG islands in human isochores

Genomics, 2010
DNA methylation is a major epigenetic modification of the genome that affects basic biological functions, such as gene expression and cell development. We used the human genome sequences and the DNA methylation data that are available in order to establish a map of the levels of GC and methylation in isochores.
Annalisa Varriale, Giorgio Bernardi
openaire   +3 more sources

Methylated-CpG Island Recovery Assay [PDF]

, 2011
Alterations in DNA methylation patterns are implicated in playing a major role in the development of cancer, thus highlighting the need to continually develop new technologies to analyze epigenetic marks. Methylated-CpG Island Recovery Assay (MIRA), based on the high affinity of the MBD2b/MDB3L1 complex for double-stranded methylated DNA, allows for ...
J. Tyson DeAngelis, Natalie Mitchell, Trygve O. Tollefsbol   +2 more
openaire   +2 more sources

The CpG Island Methylator Phenotype: What's in a Name? [PDF]

Cancer Research, 2013
Abstract Although the CpG island methylator phenotype (CIMP) was first identified and has been most extensively studied in colorectal cancer, the term “CIMP” has been repeatedly used over the past decade to describe CpG island promoter methylation in other tumor types, including bladder, breast, endometrial, gastric, glioblastoma ...
Hughes, L.A.E., Melotte, V., Schrijver, J. de, Maat, M. de, Smit, V.T.H.B.M., Bovee, J.V.M.G., French, P.J., Brandt, P.A. van den, Schouten, L.J., Meyer, T. de, Criekinge, W. van, Ahuja, N., Herman, J.G., Weijenberg, M.P., Engeland, M. van   +14 more
openaire   +6 more sources