Results 131 to 140 of about 869,007 (330)

Transform-Domain Classification of Human Cells based on DNA Methylation Datasets [PDF]

arXiv, 2019
A novel method to classify human cells is presented in this work based on the transform-domain method on DNA methylation data. DNA methylation profile variations are observed in human cells with the progression of disease stages, and the proposal is based on this DNA methylation variation to classify normal and disease cells including cancer cells. The
arxiv  

Molecular Classification of Endometrial Cancers Using an Integrative DNA Sequencing Panel

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Adoption of molecular classification in endometrial cancer (EC) into clinical practice remains challenging due to complexity in coordination of multiple assays. We aimed to develop a simple molecular technique to classify ECs into four subgroups using our custom‐designed targeted sequencing panel.
Soyoun R. Kim, Leslie Oldfield, Raymond H. Kim, Osvaldo Espin‐Garcia, Kathy Han, Danielle Vicus, Lua Eiriksson, Alicia Tone, Aaron Pollett, Matthew Cesari, Blaise Clarke, Marcus Q. Bernardini, Trevor J. Pugh, Sarah E. Ferguson   +13 more
wiley   +1 more source

CpGcluster: a distance-based algorithm for CpG-island detection

BMC Bioinformatics, 2006
Background Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defining CpG islands (CGIs), since all current approaches rely on a large ...
Carpena Pedro, Luque-Escamilla Pedro, Previti Christopher, Hackenberg Michael, Martínez-Aroza José, Oliver José L   +5 more
doaj   +1 more source

Smoking and Elevated Preneoadjuvant Chemoradiotherapy Serum Carcinoembryonic Antigen Levels Are Associated With High Tumor Regression Grade and Poor Survival in Patients With Locally Advanced Rectal Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment for patients with locally advanced rectal cancer (LARC). Tumor regression grade (TRG) is an essential prognostic factor in determining treatment efficacy. However, the potential factors influencing TRG in patients with rectal cancer who have received NACRT have not been ...
Jen‐Pin Chuang, Hsiang‐Lin Tsai, Po‐Jung Chen, Ching‐Wen Huang, Wei‐Chih Su, Tsung‐Kun Chang, Yen‐Cheng Chen, Ching‐Chun Li, Yung‐Sung Yeh, Jaw‐Yuan Wang   +9 more
wiley   +1 more source

Dissecting the Kaiso binding profile in clear renal cancer cells

Epigenetics & Chromatin
Background There has been a notable increase in interest in the transcriptional regulator Kaiso, which has been linked to the regulation of clonal hematopoiesis, myelodysplastic syndrome, and tumorigenesis.
Alexey Starshin, Pavel Abramov, Yaroslava Lobanova, Fedor Sharko, Galina Filonova, Dmitry Kaluzhny, Daria Kaplun, Igor Deyev, Alexander Mazur, Egor Prokhortchou, Svetlana Zhenilo   +10 more
doaj   +1 more source

Extensive sequence-influenced DNA methylation polymorphism in the human genome

Epigenetics & Chromatin, 2010
Background Epigenetic polymorphisms are a potential source of human diversity, but their frequency and relationship to genetic polymorphisms are unclear.
Hellman Asaf, Chess Andrew
doaj   +1 more source

CpG islands and HTF islands in the HLA class I region: investigation of the methylation status of class I genes leads to precise physical mapping of the HLA-B and -C genes [PDF]

, 1988
Pierre Pontarotti, Giovanna Chimini, Catherine Nguyen, J. Boretto, B.R. Jordan   +4 more
openalex   +1 more source

DBCAT: Database of CpG Islands and Analytical Tools for Identifying Comprehensive Methylation Profiles in Cancer Cells

J. Comput. Biol., 2011
DBCAT (database of CpG islands and analytical tools, http://dbcat.cgm.ntu.edu.tw/ ), developed to characterize comprehensive DNA methylation profiles in human cancers, is a web-based application and methylation database containing several convenient ...
Hsien-Chi Kuo, Po-Yu Lin, Ting-Chiun Chung, Chin-Mei Chao, L. Lai, M. Tsai, E. Chuang   +6 more
semanticscholar   +1 more source

Assessment of the Nutraceutical Properties of Wild Strawberry (Fragaria vesca L.) Extracts on Human Colorectal Cell Lines

Molecular Nutrition &Food Research, EarlyView.
The study explores the nutraceutical potential of wild strawberry (Fragaria vesca L.) by assessing its effects on multiple colorectal carcinoma cell lines. Wild strawberry phytochemicals were able to reduce SW480 cell viability by inducing cell cycle arrest and by promoting programmed cell death in E705 cells, with no toxicity on healthy colorectal ...
Monica Oldani, Lorenzo Guzzetti, Emiliano Pioltelli, Davide Sala, Davide Panzeri, Maura Brioschi, Matilde Forcella, Paola Fusi   +7 more
wiley   +1 more source

Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes

BMC Genomics, 2011
Background The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR).
Galván Silvia C, Martínez-Salazar Martha, Galván Víctor M, Méndez Rocío, Díaz-Contreras Gibran T, Alvarado-Hermida Moisés, Alcántara-Silva Rogelio, García-Carrancá Alejandro   +7 more
doaj   +1 more source