Results 141 to 150 of about 71,046 (242)
The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases
MedComm, Volume 7, Issue 4, April 2026.Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi +5 more
wiley +1 more source
CpG Methylation Altered the Stability and Structure of the i-Motifs Located in the CpG Islands. [PDF]
Int J Mol Sci, 2022 Oshikawa D +4 more
europepmc +1 more source
MedComm, Volume 7, Issue 4, April 2026.Clinical utility of liquid biopsy‐based epigenetic profiling in PDAC management. Aberrant methylation of LAX1, RCAN3, and NR3C1 was identified in cfDNA from mPDAC patients, highlighting their potential as non‐invasive epigenetic biomarkers. Methylation levels of these genes showed prognostic value, supporting their relevance for patient stratification ...
Pablo Cano‐Ramírez +7 more
wiley +1 more source
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. [PDF]
Nucleic Acids Res, 2023 Weber LM +16 more
europepmc +1 more source
Isocitrate Dehydrogenase‐Mutant Astrocytomas: Risk Stratification and Therapeutic Advance
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract synthesizes the core logic of our revised review by linking integrated diagnosis, risk stratification, and trajectory‐based management in IDH‐mutant astrocytomas across CNS WHO Grades 2–4. It highlights lineage‐defining molecular classification (IDH mutation with core co‐alterations), integrated histomolecular grading, and key ...
Shepeng Wei +3 more
wiley +1 more source
Sequence determinants, function, and evolution of CpG islands. [PDF]
Biochem Soc Trans, 2021 Angeloni A, Bogdanovic O.
europepmc +1 more source
Asia-Pacific Journal of Clinical Oncology, Volume 22, Issue 2, Page 260-269, April 2026.We selected breast cancer‐specific DNA methylation markers using The Cancer Genome Atlas (TCGA). We analyzed the methylation and expression patterns of candidate genes in breast cancer cell lines, ctDNA, and tissue samples. The relationship between ctDNA methylation markers and the clinicopathological features of breast cancer patients was investigated.
Young Ju Jeong +6 more
wiley +1 more source
Profiling ascidian promoters as the primordial type of vertebrate promoter
BMC Genomics, 2011 Background CpG islands are observed in mammals and other vertebrates, generally escape DNA methylation, and tend to occur in the promoters of widely expressed genes.
Okamura Kohji +6 more
doaj +1 more source
DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B. [PDF]
Sci Rep, 2022 Loaeza-Loaeza J +6 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source