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Current Opinion in Genetics & Development, 1995
Of the estimated 45,000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands.
S H, Cross, A P, Bird
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Of the estimated 45,000 CpG islands in the human genome, the overwhelming majority are found at the 5' ends of genes and their identification and cloning are proving very useful for finding and isolating genes. Recent work has shed light on the chromosomal distribution and origin of CpG islands.
S H, Cross, A P, Bird
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Epigenomics: beyond CpG islands
Nature Reviews Genetics, 2004Epigenomic studies aim to define the location and nature of the genomic sequences that are epigenetically modified. Much progress has been made towards whole-genome epigenetic profiling using molecular techniques, but the analysis of such large and complex data sets is far from trivial given the correlated nature of sequence and functional ...
Melissa J, Fazzari, John M, Greally
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CpG Islands in vertebrate genomes
Journal of Molecular Biology, 1987Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been shown that some vertebrate genes contain CpG islands, regions of DNA with a high G+C content and a high frequency of CpG dinucleotides relative to the bulk genome.
M, Gardiner-Garden, M, Frommer
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CpG Islands in Human X‐Inactivation
Annals of Human Genetics, 2003SummarySequence comparison analyses have been carried out for 19 genes escaping X‐inactivation versus 73 genes subject to X‐inactivation, and 100 randomly chosen X chromosome genes versus 100 randomly chosen autosomal genes. The coding sequence of the genes and their upstream and downstream flanking sequences were investigated using a series of windows
Ke, X., Collins, A.
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Methylation Analysis of CpG Islands
2003The application of Southern blotting to determine the methylation status of a particular gene has already been alluded to in Chapter 17 by Tennant et al., and methodology for Southern blotting described. This chapter examines methylation analysis of CpG islands in more depth and describes a technique by which quantitative changes may be monitored with ...
R, Lilischkis, H, Kneitz, H, Kreipe
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Alternative chromatin structure at CpG islands
Cell, 1990Actively transcribed chromatin is structurally different from bulk inactive chromatin. It has been difficult to define the molecular basis of the difference, however, because purified fractions of active chromatin were not available. We have overcome this problem by releasing oligonucleosomes from the nonmethylated CpG-rich islands (CpG islands) of ...
J, Tazi, A, Bird
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2017
This is an introductory bioinformatics exercise intended for use in a genetics course.
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This is an introductory bioinformatics exercise intended for use in a genetics course.
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CpG island methylator phenotype in cancer
Nature Reviews Cancer, 2004DNA hypermethylation in CpG-rich promoters is now recognized as a common feature of human neoplasia. However, the pathophysiology of hyper-methylation (why, when, where) remains obscure. Cancers can be classified according to their degree of methylation, and those cancers with high degrees of methylation (the CpG island methylator phenotype, or CIMP ...
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