Results 171 to 180 of about 898,079 (297)

Telomere Position Effect‐Over Long Distances Acts as a Genome‐Wide Epigenetic Regulator Through a Common Alu Element

Aging Cell, EarlyView.
Proposed TPE‐OLD model. TPE‐OLD genes are defined by a progressive modulation of gene expression following telomere attrition. In our study, focusing on the molecular mechanism of TPE‐OLD, we found that the TPE‐OLD loop requires a cis‐signature corresponding to a newly evolved Alu repeats (AluY). The Alu repeat can be either in an intergenic region, as
Raphaël Chevalier, Victor Murcia Pienkowski, Nicolas Jullien, Leslie Caron, Pascal Verdier Pinard, Frédérique Magdinier, Jérôme D. Robin   +6 more
wiley   +1 more source

DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B. [PDF]

Sci Rep, 2022
Loaeza-Loaeza J, Cerecedo-Castillo AJ, Rodríguez-Ruiz HA, Castro-Coronel Y, Del Moral-Hernández O, Recillas-Targa F, Hernández-Sotelo D.   +6 more
europepmc   +1 more source

A Distinct Sequence (ATAAA) Separates Methylated and Unmethylated Domains at the 5′-End of theGSTP1 CpG Island* [PDF]

, 2000
Douglas Millar, Cheryl Paul, Peter L. Molloy, Susan J. Clark   +3 more
openalex   +1 more source

The molecular basis of lactase persistence: Linking genetics and epigenetics

Annals of Human Genetics, EarlyView.
Abstract Lactase persistence (LP) — the genetic trait that determines the continued expression of the enzyme lactase into adulthood — has undergone recent, rapid positive selection since the advent of animal domestication and dairying in some human populations.
Céleste E. Cohen, Dallas M. Swallow, Catherine Walker   +2 more
wiley   +1 more source

CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers. [PDF]

BMC Bioinformatics, 2022
Maruyama O, Li Y, Narita H, Toh H, Au Yeung WK, Sasaki H.   +5 more
europepmc   +1 more source

DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]

, 2004
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Andrews, TD, Beck, S, Berlin, K, Cox, AV, Fischer, J, Gut, IG, Hildmann, T, Howe, KL, Lewin, J, Novik, KL, Olek, A, Otto, T, Rakyan, VK, Tost, J   +13 more
core  

Genetic Instability and Aberrant DNA Methylation in Chronic Hepatitis and Cirrhosis—A Comprehensive Study of Loss of Heterozygosity and Microsatellite Instability at 39 Loci and DNA Hypermethylation on 8 CpG Islands in Microdissected Specimens From Patients With Hepatocellular Carcinoma [PDF]

, 2000
Yutaka Kondo, Yae Kanai, Michiie Sakamoto, Masashi Mizokami, Ryuzo Ueda, Setsuo Hirohashi   +5 more
openalex   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region. [PDF]

Anal Cell Pathol (Amst), 2022
Liu J, Yu N, Feng X, He Y, Lv K, Zhu H, Wang J.   +6 more
europepmc   +1 more source

Role of Hypermethylation of DAP-Kinase CpG Island in the Development of Thyroid Lymphoma [PDF]

, 2000
Shin‐ichi Nakatsuka, Tetsuya Takakuwa, Yasuhiko Tomita, Hideaki Miwa, Fumio Matsuzuka, Katsuyuki Aozasa   +5 more
openalex   +1 more source