Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. [PDF]
PLoS Genetics, 2007 The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG ...
Lanlan Shen +9 more
doaj +1 more source
GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences
BMC Genomics, 2017 Background As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome ...
Ning Yu +3 more
doaj +1 more source
Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping [PDF]
Journal of Clinical Laboratory Analysis, 2015 BackgroundDetermination of the differential DNA methylation patterns of methylenetetrahydrofolate reductase (MTHFR) that are associated with differential MTHFR activity is important to understand the pathogenesis of ischemic stroke. However, to date, no data are available on the differential DNA methylation profiles of Kelantanese Malays. Therefore, we
Loo, Keat Wei +6 more
openaire +3 more sources
An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits
Frontiers in Genetics, 2019 Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research.
Xiao Wang, Haja N. Kadarmideen
doaj +1 more source
Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. [PDF]
PLoS ONE, 2014 DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples.
Wengang Song +6 more
doaj +1 more source
Embryo culture in presence of oviductal fluid induces DNA methylation changes in bovine blastocysts [PDF]
, 2017 During the transit through the oviduct, the early embryo initiates an extensive DNA methylation reprogramming of its genome. Given that these epigenetic modifications are susceptible to environmental factors, components present in the oviductal milieu ...
Barrera, Antonio Daniel +7 more
core +1 more source
BMC Medical Genomics, 2008 Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.
DeGeest Koen +5 more
doaj +1 more source
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. [PDF]
PLoS Genetics, 2012 We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands.
Altuna Akalin +21 more
doaj +1 more source
Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core +1 more source
Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]
, 2014 BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Bird, Adrian +2 more
core +1 more source