Results 31 to 40 of about 869,007 (330)

Molecular and cellular paradigms of multidrug resistance in cancer

Cancer Reports, Volume 5, Issue 12, December 2022., 2022
Abstract Background The acquisition of resistance to chemotherapy is a major hurdle in the successful application of cancer therapy. Several anticancer approaches, including chemotherapies, radiotherapy, surgery and targeted therapies are being employed for the treatment of cancer.
Foram U. Vaidya, Abu Sufiyan Chhipa, Vinita Mishra, Vishal Kumar Gupta, Shiv Govind Rawat, Ajay Kumar, Chandramani Pathak   +6 more
wiley   +1 more source

A companion to the preclinical common data elements for genomics, transcriptomics, and epigenomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines. The aim of the CDEs is to improve the standardization of experimental designs across a range of epilepsy ...
Erwin A. van Vliet, Michael S. Hildebrand, James D. Mills, Gary P. Brennan, Tore Eid, Susan A. Masino, Vicky Whittemore, Laura Bindila, Kevin K. Wang, Manisha Patel, Piero Perucca, Christopher A. Reid   +11 more
wiley   +1 more source

Intergenic, gene terminal, and intragenic CpG islands in the human genome

BMC Genomics, 2010
Background Recently, it has been discovered that the human genome contains many transcription start sites for non-coding RNA. Regulatory regions related to transcription of this non-coding RNAs are poorly studied.
Kulakovskiy Ivan V, Ermakova Ekaterina O, Malko Dmitry B, Oparina Nina J, Fridman Marina V, Medvedeva Yulia A, Heinzel Andreas, Makeev Vsevolod J   +7 more
doaj   +1 more source

DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy

International Journal of Cancer, Volume 152, Issue 5, Page 1025-1035, 1 March 2023., 2023
What's new? While early diagnosis of triple‐negative breast cancer (TNBC) is associated with heightened responsiveness to chemotherapy, biomarkers that can be detected noninvasively are needed to support early TNBC diagnosis. Our study suggests that such markers may exist in the form of methylation signatures in cell‐free DNA. Evaluation of methylation
Mehdi Manoochehri, Nasim Borhani, Clarissa Gerhäuser, Yassen Assenov, Maximilian Schönung, Thomas Hielscher, Brock C. Christensen, Min Kyung Lee, Hermann‐Josef Gröne, Daniel B. Lipka, Thomas Brüning, Hiltrud Brauch, Yon‐Dschun Ko, Ute Hamann   +13 more
wiley   +1 more source

Teeing Up Transcription on CpG Islands [PDF]

Journal of End-to-End-testing, 2009
Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al ...
Harinder Singh, Harinder Singh
openaire   +3 more sources

Comprehensive analysis of CpG islands in human chromosomes 21 and 22

Proceedings of the National Academy of Sciences of the United States of America, 2002
CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their genomes. In addition, CpG islands located in the promoter regions of genes can play important roles in gene silencing during processes such as X-chromosome ...
D. Takai, Peter A. Jones
semanticscholar   +1 more source

CpG Islands Shape the Epigenome Landscape

Journal of Molecular Biology, 2021
Epigenetic modifications and nucleosome positioning play an important role in modulating gene expression. However, how the patterns of epigenetic modifications and nucleosome positioning are established around promoters is not well understood.
Papin, Christophe, Le Gras, Stéphanie, Ibrahim, Abdulkhaleg, Salem, Hatem, Karimi, Mohammad Mahdi, Stoll, Isabelle, Ugrinova, Iva, Schröder, Maria, Fontaine-Pelletier, Emeline, Omran, Ziad, Bronner, Christian, Dimitrov, Stefan, Hamiche, Ali   +12 more
openaire   +4 more sources

Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping [PDF]

Journal of Clinical Laboratory Analysis, 2015
BackgroundDetermination of the differential DNA methylation patterns of methylenetetrahydrofolate reductase (MTHFR) that are associated with differential MTHFR activity is important to understand the pathogenesis of ischemic stroke. However, to date, no data are available on the differential DNA methylation profiles of Kelantanese Malays. Therefore, we
Loo Keat Wei, Loo Keat Wei, Siew Hua Gan, Emily T. Camilleri, Lyn R. Griffiths, Heidi G. Sutherland, Larisa M. Haupt, Anthony Au   +7 more
openaire   +3 more sources

Putative zinc finger protein binding sites are over-represented in the boundaries of methylation-resistant CpG islands in the human genome.

PLoS ONE, 2007
BackgroundMajority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are resistant to such epigenetic modification. Understanding about mechanisms that may lead to the methylation resistance of CpG islands is
Shicai Fan, Fang Fang, Xuegong Zhang, Michael Q Zhang   +3 more
doaj   +1 more source

An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21 [PDF]

Computational Biology and Chemistry, 28(5-6): 393-399 (2004), 2004
An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb. Five cycles of oscillation are observed in this region with six GC-rich peaks and five GC-poor valleys ...
arxiv   +1 more source