Results 1 to 10 of about 146 (99)

CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression [PDF]

Journal of Experimental & Clinical Cancer Research, 2021
Background Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini.
Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, Tao Zhu, Jielin Sun, Xiaodong Zhao   +11 more
doaj   +3 more sources

CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation

Cell Reports, 2023
Summary: Cancer cells usually exhibit shortened 3′ untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration.
Susu Liu, Runze Wu, Liutao Chen, Ke Deng, Xin Ou, Xin Lu, Mengxia Li, Chao Liu, Shangwu Chen, Yonggui Fu, Anlong Xu   +10 more
doaj   +3 more sources

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

mBio, 2020
Lentiviral DNA integration favors transcriptionally active chromatin. We previously showed that the interaction of human immunodeficiency virus type 1 (HIV-1) capsid with cleavage and polyadenylation specificity factor 6 (CPSF6) localizes viral ...
Wen Li, Parmit K. Singh, Gregory A. Sowd, Gregory J. Bedwell, Sooin Jang, Vasudevan Achuthan, Amarachi V. Oleru, Doris Wong, Hind J. Fadel, KyeongEun Lee, Vineet N. KewalRamani, Eric M. Poeschla, Alon Herschhorn, Alan N. Engelman   +13 more
doaj   +3 more sources

IGF2BP2 binding to CPSF6 facilitates m6A‐mediated alternative polyadenylation of PUM2 and promotes malignant progression in ovarian cancer

Clinical and Translational Medicine
Background N6‐methyladenosine (m6A) and alternative polyadenylation (APA) are common posttranscriptional regulatory mechanisms in eukaryotes. However, the m6A‐dependent mechanism of APA regulation in ovarian cancer (OC) is still unclear.
Xin Luo, Qinglv Wei, Lingcui Xie, Ningxuan Chen, Bin Gu, Jiani Xu, Xiaoyan Jiang, Xinzhao Zuo, Hongyan Zhao, Xiaoyi Liu, Yu Yang, Tao Liu, Yong Zhu, Ping Yi, Jing Xu   +14 more
doaj   +2 more sources

Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3′UTR in Gastric Cancer Cells

Frontiers in Genetics, 2021
Alternative polyadenylation (APA) is an important RNA post-transcriptional process, which can generate diverse mRNA isoforms. Increasing evidence shows that APA is involved in cell self-renewal, development, immunity, and cancer. CPSF6 is one of the core
Xinglong Shi, Keshuo Ding, Keshuo Ding, Qiang Zhao, Pengxiao Li, Yani Kang, Sheng Tan, Jielin Sun   +7 more
doaj   +1 more source

In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects. [PDF]

PLoS Pathogens, 2014
The host protein CPSF6 possesses a domain that can interact with the HIV-1 capsid (CA) protein. CPSF6 has been implicated in regulating HIV-1 nuclear entry. However, its functional significance for HIV-1 replication has yet to be firmly established. Here
Matthew S Henning, Brittany N Dubose, Mallori J Burse, Christopher Aiken, Masahiro Yamashita   +4 more
doaj   +1 more source

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection

Scientific Reports, 2023
The early events of HIV-1 infection involve the transport of the viral core into the nucleus. This event triggers the translocation of CPSF6 from paraspeckles into nuclear speckles forming puncta-like structures.
Charlotte Luchsinger, KyeongEun Lee, Gonzalo A. Mardones, Vineet N. KewalRamani, Felipe Diaz-Griffero   +4 more
doaj   +1 more source

Ribonucleic acid-binding protein CPSF6 promotes glycolysis and suppresses apoptosis in hepatocellular carcinoma cells by inhibiting the BTG2 expression

BioMedical Engineering OnLine, 2021
Hepatocellular carcinoma (HCC) is currently the sixth most common malignancy and the second major cause of tumor-related deaths in the world. This study aimed to investigate the role of cleavage and polyadenylation factor-6 (CPSF6) and B-cell ...
Yang Liu, Hongbo Zou, Qichao Xie, Lan Zou, Rui Kong, Bijing Mao   +5 more
doaj   +1 more source

A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

eLife, 2023
Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the discovery that the mTORC1 signaling pathway balances the expression of two Trim9/TRIM9 isoforms through APA regulation in human and mouse.
R Samuel Herron, Alexander K Kunisky, Jessica R Madden, Vivian I Anyaeche, May Z Maung, Hun-Way Hwang   +5 more
doaj   +1 more source

Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

mBio, 2021
CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin.
Yue Zheng, Heidi L. Schubert, Parmit K. Singh, Laura J. Martins, Alan N. Engelman, Iván D’Orso, Christopher P. Hill, Vicente Planelles   +7 more
doaj   +1 more source