Results 11 to 20 of about 146 (99)

CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target [PDF]

EBioMedicine, 2017
Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist.
Najat Binothman, Ibrahim Y. Hachim, Jean-Jacques Lebrun, Suhad Ali   +3 more
doaj   +4 more sources

CPSF6 promotes HIV-1 preintegration complex function

Journal of Virology
Cleavage and polyadenylation specificity factor 6 (CPSF6) is part of the cellular cleavage factor I mammalian (CFIm) complex that regulates mRNA processing and polyadenylation.
Evan Chaudhuri, Sooin Jang, Rajasree Chakraborty, Rajalingam Radhakrishnan, Bjarki Arnarson, Prem Prakash, Daphne Cornish, Nicholas Rohlfes, Parmit K. Singh, Jiong Shi, Christopher Aiken, Edward Campbell, Judd Hultquist, Muthukumar Balsubramaniam, Alan N. Engelman, Chandravanu Dash   +15 more
doaj   +3 more sources

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. [PDF]

PLoS Pathogens, 2012
The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with
Amanda J Price, Adam J Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N KewalRamani, Jason W Chin, Greg J Towers, Leo C James   +8 more
doaj   +5 more sources

NUDT21 Suppresses Breast Cancer Tumorigenesis Through Regulating CPSF6 Expression

Cancer Management and Research, 2020
Bi-Jun Wang,1,* Da-Chao Liu,1,* Qian-Ying Guo,2,* Xiao-Wen Han,2 Xiao-Min Bi,2 Hao Wang,2 Zheng-Sheng Wu,2 Wen-Yong Wu1 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of ...
Wang BJ, Liu DC, Guo QY, Han XW, Bi XM, Wang H, Wu ZS, Wu WY   +7 more
doaj   +4 more sources

Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration [PDF]

Therapeutic Advances in Hematology, 2021
Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han, Chunxiang Jin, Gaofeng Zheng, Yi Li, Yungui Wang, Enfan Zhang, Honghu Zhu, Zhen Cai   +7 more
doaj   +3 more sources

HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

eLife, 2019
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infection. The host protein cleavage-and-polyadenylation-specificity-factor-6 (CPSF6) has been implicated in different stages of early HIV-1 ...
David Alejandro Bejarano, Ke Peng, Vibor Laketa, Kathleen Börner, K Laurence Jost, Bojana Lucic, Bärbel Glass, Marina Lusic, Barbara Müller, Hans-Georg Kräusslich   +9 more
doaj   +3 more sources

Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner

mBio, 2021
HIV is the causative agent of AIDS, which has no cure. The protein shell that encases the viral genome, the capsid, is critical for HIV replication in cells at multiple steps.
Zhou Zhong, Jiying Ning, Emerson A. Boggs, Sooin Jang, Callen Wallace, Cheryl Telmer, Marcel P. Bruchez, Jinwoo Ahn, Alan N. Engelman, Peijun Zhang, Simon C. Watkins, Zandrea Ambrose   +11 more
doaj   +4 more sources

Downregulation of CPSF6 leads to global mRNA 3' UTR shortening and enhanced antiviral immune responses.

PLoS Pathogens
Alternative polyadenylation (APA) is a widespread mechanism of gene regulation that generates mRNA isoforms with alternative 3' untranslated regions (3' UTRs).
Yong Ge, Jingrong Huang, Rong Chen, Yonggui Fu, Tao Ling, Xin Ou, Xiaohui Rong, Youxiang Cheng, Yi Lin, Fengyi Zhou, Chuanjian Lu, Shaochun Yuan, Anlong Xu   +12 more
doaj   +3 more sources

The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection.

PLoS Pathogens
The early stages of HIV-1 infection include the trafficking of the viral core into the nucleus of infected cells. However, much remains to be understood about how HIV-1 accomplishes nuclear import and the consequences of the import pathways utilized on ...
Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K Singh, Gregory J Bedwell, Alan N Engelman, Adarsh Dharan, Edward M Campbell   +6 more
doaj   +4 more sources

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

mBio
Human immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration.
Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose   +12 more
doaj   +5 more sources