Results 21 to 30 of about 146 (99)

HIV-Induced CPSF6 Condensates

Journal of Molecular Biology, 2023
Viruses are obligate parasites that rely on their host's cellular machinery for replication. To facilitate their replication cycle, many viruses have been shown to remodel the cellular architecture by inducing the formation of membraneless organelles (MLOs).
Ay, Selen, Di Nunzio, Francesca
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PP 1.17 – 00103 The Ubiquitin Ligase ITCH and CPSF6 Control HIV Transcription

Journal of Virus Eradication, 2022
V. Planelles, C. Espinel, L. Martins, A. Spivak, Y. Zheng   +4 more
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The roles of CPSF6 in proliferation, apoptosis and tumorigenicity of lung adenocarcinoma

Aging, 2022
Cleavage and polyadenylation specific factor 6 (CPSF6), a member of serine/arginine-rich protein family, is implicated in HIV-1-infection and replication. Overexpression of CPSF6 predicts poor prognostic outcomes of breast cancer. However, the expression and possible function of CPSF6 in lung adenocarcinoma (LUAD) still needs to be explored.
Zu, Yukun, Wang, Dao, Ping, Wei, Sun, Wei   +3 more
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CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia

Nature Communications
Acute myeloid leukemia (AML) with retinoic acid receptor gamma (RARG) fusions, which exhibits clinical features resembling acute promyelocytic leukemia (APL), has been identified as a new subtype with poor clinical outcomes.
Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu   +11 more
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Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock

PLOS Biology, 2023
A defining property of circadian clocks is temperature compensation, characterized by the resilience of their near 24-hour free-running periods against changes in environmental temperature within the physiological range. While temperature compensation is evolutionary conserved across different taxa of life and has been studied within many model ...
Christoph Schmal, Bert Maier, Reut Ashwal-Fluss, Osnat Bartok, Anna-Marie Finger, Tanja Bange, Stella Koutsouli, Maria S. Robles, Sebastian Kadener, Hanspeter Herzel, Achim Kramer   +10 more
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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Events that occur between entry of the HIV-1 capsid into the cytoplasm of the target cell and the delivery of the viral genetic material into the nucleus constitute some of the less well understood processes in the viral life cycle.
Akash, Bhattacharya, Steven L, Alam, Thomas, Fricke, Kaneil, Zadrozny, Jaroslaw, Sedzicki, Alexander B, Taylor, Borries, Demeler, Owen, Pornillos, Barbie K, Ganser-Pornillos, Felipe, Diaz-Griffero, Dmitri N, Ivanov, Mark, Yeager   +11 more
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Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration [PDF]

JoLS, Journal of Life Sciences, 2019
HIV-1 integration favors active chromatin, which is primarily mediated through interactions between the viral capsid and integrase proteins with host factors cleavage and polyadenylation specificity factor 6 (CPSF6) and lens epithelium-derived growth factor/p75, respectively.
Vasudevan, Achuthan, Jill M, Perreira, Jenny J, Ahn, Abraham L, Brass, Alan N, Engelman   +4 more
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RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer

World Journal of Gastrointestinal Oncology, 2023
Pancreatic cancer (PanCa) presents a catastrophic disease with poor overall survival at advanced stages, with immediate requirement of new and effective treatment options. Besides genetic mutations, epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target. Mechanisms beneath the deoxyribonucleic
Wang, Xue-Jun, Liu, Yong, Ke, Bin, Zhang, Li, Liang, Han   +4 more
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Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid [PDF]

Journal of Virology, 2018
ABSTRACT Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration complexes. Truncation of the protein at its C-terminal nuclear-targeting arginine/serine-rich (RS) domain produces a protein, CPSF6-358 ...
Ning, J, Zhong, Z, Fischer, D, Harris, G, Watkins, S, Ambrose, Z, Zhang, P   +6 more
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Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection

Nature Communications, 2022
Host proteins CPSF6, NUP153, and SEC24C are vital for HIV-1 infection. They bind to the viral capsid protein and contribute to shuttling of virions through the cytoplasm (SEC24C), import into the nucleus (NUP153 and CPSF6) and subsequent trafficking to ...
Guochao Wei, Naseer Iqbal, Valentine V. Courouble, Ashwanth C. Francis, Parmit K. Singh, Arpa Hudait, Arun S. Annamalai, Stephanie Bester, Szu-Wei Huang, Nikoloz Shkriabai, Lorenzo Briganti, Reed Haney, Vineet N. KewalRamani, Gregory A. Voth, Alan N. Engelman, Gregory B. Melikyan, Patrick R. Griffin, Francisco Asturias, Mamuka Kvaratskhelia   +18 more
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