Results 51 to 60 of about 146 (99)

HIV-1 Capsid Rapidly Induces Long-Lived CPSF6 Puncta in Non-Dividing Cells, but Similar Puncta Already Exist in Uninfected T-Cells

Viruses
The HIV-1 capsid (CA) protein forms the outer shell of the viral core that is released into the cytoplasm upon infection. CA binds various cellular proteins, including CPSF6, that direct HIV-1 integration into speckle-associated domains in host chromatin.
Anabel Guedán, Megan Burley, Eve R. Caroe, Kate N. Bishop   +3 more
doaj   +1 more source

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Nature Communications, 2020
Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially ...
Ashwanth C. Francis, Mariana Marin, Parmit K. Singh, Vasudevan Achuthan, Mathew J. Prellberg, Kristina Palermino-Rowland, Shuiyun Lan, Philip R. Tedbury, Stefan G. Sarafianos, Alan N. Engelman, Gregory B. Melikyan   +10 more
doaj   +1 more source

Effects of Differential Commercial Husbandry Conditions on the Tasmanian Atlantic Salmon Egg Transcriptome

Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.
ABSTRACT Maternally inherited transcripts are crucial for the developmental competence of salmon embryos. Due to the wide variety of broodstock conditioning approaches used in commercial aquaculture, there is a need to understand how dynamic commercial environments impact the egg transcriptome and subsequent quality.
Xin Zhan, Mark Adams, Louise Adams, Gianluca Amoroso, Kelli Anderson   +4 more
wiley   +1 more source

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. [PDF]

PLoS Pathogens, 2013
Lentiviruses can infect non-dividing cells, and various cellular transport proteins provide crucial functions for lentiviral nuclear entry and integration.
Kenneth A Matreyek, Sara S Yücel, Xiang Li, Alan Engelman   +3 more
doaj   +1 more source

Differential effects of age and sex on tau pathology propagation in the htau mouse model: A neuropathological and proteomic study

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Aging is the main risk factor for Alzheimer's disease (AD), acting through still poorly understood mechanisms. AD is associated with the development of a tau pathology, a hallmark lesion propagating in the brain along neuroanatomically connected pathways.
Andreea‐Claudia Kosa, Lidia Lopez‐Gutierrez, Kunie Ando, Emilie Doeraene, Emmanuel Aydin, Hinde Lasri, Alain Wathelet‐Depauw, Karlien Pieters, David Van Morckhoven, Virginie Imbault, Christine Dubois, Xavier Bisteau, Basile Stamatopoulos, Mariana Igoillo‐Esteve, Jean‐Pierre Brion, Karelle Leroy   +15 more
wiley   +1 more source

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly.

PLoS Pathogens, 2014
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands.
Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James   +8 more
doaj   +1 more source

Alternative Polyadenylation Contributes to Fibroblast Senescence in Pulmonary Fibrosis

Aging Cell, Volume 24, Issue 10, October 2025.
In aging or fibrotic fibroblasts, NUDT21 is downregulated, leading to alternative polyadenylation/3′ UTR shortening of STAT3 pathway genes, enhancing their protein expression and promoting STAT3 phosphorylation. Activated STAT3 signaling subsequently drives the expression and release of senescence‐associated secretory phenotype (SASP) factors, thereby ...
Jingjing Huang, Maria Jose Gacha‐Garay, Yu Wang, Scott D. Collum, Rene A. Girard, Hydia Puente, Seung‐Hee Yoo, Rahat Hussain, Jayeshkumar Patel, Manish Patel, Eric J. Wagner, Hari KrishnaYalamanchili, Harry Karmouty‐Quintana, Zheng Chen, Tingting Mills   +14 more
wiley   +1 more source

Unique Genetic and Epigenetic Alterations in Glioblastoma Long‐Term Survivors: Insights From Two Clinical Cases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT The biological mechanisms driving the long survival in glioblastoma (GBM). Five‐year long‐term survival (LTS) and 10‐year survival very long‐term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR10‐046 (VLTS) was affected by a giant cell‐GBM, classified as the pedHGG_RTK1a subtype according to the ...
Elena Anghileri, Evelina Miele, Sara Patrizi, Sabina Barresi, Elisabetta Lazzarini, Luisa Maddaloni, Monica Patanè, Lucia Pedace, Rosina Paterra, Antonio Silvani, Franco Locatelli, Stefano Indraccolo, Bianca Pollo   +12 more
wiley   +1 more source

A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]

Blood Advances, 2018
Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Miller, Christopher A., Tricarico, Christopher, Skidmore, Zachary L., Uy, Geoffrey L., Lee, Yi-Shan, Hassan, Anjum, O'Laughlin, Michelle D., Schmidt, Heather, Tian, Ling, Duncavage, Eric J., Griffith, Malachi, Griffith, Obi L., Welch, John S., Wartman, Lukas D.   +13 more
openaire   +4 more sources

CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos

Stem Cell Reports, 2023
Summary: Alternative polyadenylation (APA) gives rise to transcripts with distinct 3′ untranslated regions (3′ UTRs), thereby affecting the fate of mRNAs.
Na Li, Ying Cai, Min Zou, Jian Zhou, Ling Zhang, Liquan Zhou, Wenpei Xiang, Yan Cui, Huaibiao Li   +8 more
doaj   +1 more source