Results 71 to 80 of about 146 (99)

N6‐Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases

Immunity, Inflammation and Disease, Volume 12, Issue 12, December 2024.
N6‐methyladenosine (m6A) modification, a prevalent and reversible epigenetic modification in eukaryotic mRNA, has emerged as a crucial regulator in various biological processes. Recent studies have shed light on the significant role of m6A modification in female reproductive development and its related diseases.
Xiangrong Cui, Huihui Li, Xia Huang, Tingting Xue, Shu Wang, Xinyu Zhu, Xuan Jing   +6 more
wiley   +1 more source

Reading m6A marks in mRNA: A potent mechanism of gene regulation in plants

Journal of Integrative Plant Biology, Volume 66, Issue 12, Page 2586-2599, December 2024.
This review examines N6‐methyladenosine (m6 A) metabolism, including how m6A readers, writers, and erasers recognize and interpret m6A modification on mRNAs; how they regulate the stability, splicing, transport, and translation of mRNAs; and how they function in the response of plants to developmental and environmental signals.
Thi Kim Hang Nguyen, Hunseung Kang
wiley   +1 more source

Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV‐CA Binding Fragments

ChemMedChem, Volume 19, Issue 13, July 2, 2024.
HIV capsid protein plays a major role in the viral life cycle and has emerged as an important target. We used NMR fragment screening to identify molecules that bind to HIV capsid. X‐ray crystallography demonstrated the binding mode of these compounds, allowing rapid progression of the initial, weak binding, fragment starting points to compounds with ...
Stuart Lang, Daniel A. Fletcher, Alain‐Pierre Petit, Nicola Luise, Paul Fyfe, Fabio Zuccotto, David Porter, Anthony Hope, Fiona Bellany, Catrina Kerr, Claire J. Mackenzie, Paul G. Wyatt, David W. Gray   +12 more
wiley   +1 more source

Quantitative microscopy of functional HIV post-entry complexes reveals association of replication with the viral capsid

eLife, 2014
The steps from HIV-1 cytoplasmic entry until integration of the reverse transcribed genome are currently enigmatic. They occur in ill-defined reverse-transcription- and pre-integration-complexes (RTC, PIC) with various host and viral proteins implicated.
Ke Peng, Walter Muranyi, Bärbel Glass, Vibor Laketa, Stephen R Yant, Luong Tsai, Tomas Cihlar, Barbara Müller, Hans-Georg Kräusslich   +8 more
doaj   +1 more source

Multiple urinary peptides display distinct sex‐specific distribution

PROTEOMICS, Volume 24, Issue 5, March 2024.
Abstract Previous studies have established the association of sex with gene and protein expression. This study investigated the association of sex with the abundance of endogenous urinary peptides, using capillary electrophoresis‐coupled to mass spectrometry (CE‐MS) datasets from 2008 healthy individuals and patients with type II diabetes, divided in ...
Ioanna K. Mina, Emmanouil Mavrogeorgis, Justyna Siwy, Riste Stojanov, Harald Mischak, Agnieszka Latosinska, Vera Jankowski   +6 more
wiley   +1 more source

Additional file 2 of CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression

, 2021
Additional file 2 Supplementary Table S1. Clinicopathologic correlation of CPSF6 expression in HCCs. The expression level of CPSF6 protein was detected by immunohistochemistry.
Tan, Sheng, Zhang, Ming, Xinglong Shi, Keshuo Ding, Zhao, Qiang, Qianying Guo, Wang, Hao, Zhengsheng Wu, Kang, Yani, Zhu, Tao, Jielin Sun, Xiaodong Zhao   +11 more
openaire   +1 more source

Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration

Cell Reports, 2015
Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an imaging approach, ViewHIV, which allows evaluation of early HIV-1 replication intermediates ...
Christopher R. Chin, Jill M. Perreira, George Savidis, Jocelyn M. Portmann, Aaron M. Aker, Eric M. Feeley, Miles C. Smith, Abraham L. Brass   +7 more
doaj   +1 more source

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.

PLoS Genetics, 2018
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs.
Seth D Kasowitz, Jun Ma, Stephen J Anderson, N Adrian Leu, Yang Xu, Brian D Gregory, Richard M Schultz, P Jeremy Wang   +7 more
doaj   +1 more source

Analysis of CA Content and CPSF6 Dependence of Early HIV-1 Replication Complexes in SupT1-R5 Cells

mBio, 2019
The HIV-1 capsid performs essential functions during early viral replication and is an interesting target for novel antivirals. Thus, understanding molecular and structural details of capsid function will be important for elucidating early HIV-1 (and retroviral in general) replication in relevant target cells and may also aid antiviral development ...
Vojtech Zila, Thorsten G. Müller, Vibor Laketa, Barbara Müller, Hans-Georg Kräusslich   +4 more
openaire   +3 more sources

Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease

Genome Medicine
Background Circular RNAs (circRNAs) are highly stable regulators, often accumulated in mammalian brains and thought to serve as “memory molecules” that govern the long process of aging.
Feng Wang, Yangping Li, Huifeng Shen, Paula Martinez-Feduchi, Xingyu Ji, Peng Teng, Siddharth Krishnakumar, Jian Hu, Li Chen, Yue Feng, Bing Yao   +10 more
doaj   +1 more source