Results 231 to 240 of about 146,934 (341)

Fabrication of Fructooligosaccharide‐Larimichthys crocea Peptide Copolymer by Wet‐Heating for Enhanced Calcium Delivery and Bone‐Lipid Metabolism Regulation

open access: yesFood Science &Nutrition, Volume 14, Issue 1, January 2026.
A food‐derived fructooligosaccharide‐Larimichthys crocea peptide (FOS‐LCP) copolymer was prepared by wet‐heating and exhibited high calcium‐binding capacity and enhanced intestinal calcium uptake compared with native peptides. In bone marrow mesenchymal stem cells from calcium‐deficient mice, FOS‐LCP was found to promote osteogenesis while suppressing ...
Chunlei Liu   +3 more
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

open access: yesJournal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U   +6 more
wiley   +1 more source

Targeted Delivery of Microneurotrophin BNN27 via Biomaterial Grafts Protects Retinal Ganglion Cells After Optic Nerve Injury

open access: yesJournal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 1, January 2026.
ABSTRACT Emerging neurotrophin treatments for optic nerve injury (ONI) aim to prevent the loss of retinal ganglion cells (RGCs) and enhance axonal regeneration. Microneurotrophins (MNTs), small‐molecule mimetics of neurotrophins, have shown neuroprotective effects in various animal models of neurodegeneration, yet MNT effects on ONI remain unknown ...
K. Georgelou   +13 more
wiley   +1 more source

Pharmacological Inhibition of EZH2 by GSK‐343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury

open access: yesJournal of Neuroscience Research, Volume 104, Issue 1, January 2026.
In a mouse model of spinal cord injury, pharmacological inhibition of EZH2 with GSK‐343 reduces tissue damage and neuronal demyelination. GSK‐343 suppresses the EZH2/TRAF6/NF‐κB signaling pathway, leading to attenuation of neuroinflammation and innate immune activation. These effects promote early neuroprotection and improved locomotor recovery in vivo.
Yinhui Kang   +9 more
wiley   +1 more source

Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. [PDF]

open access: yesNat Commun
Fu H   +16 more
europepmc   +1 more source

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain

open access: green, 2017
R. Aldrin Denny   +13 more
openalex   +1 more source

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