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Therapeutic applications of CRISPR-Cas9 gene editing [PDF]
Frontiers in Genome EditingCRISPR-Cas9 is a gene editing tool used extensively in biological research that is now making its way into clinical therapies. With the first CRISPR therapy obtaining approval by the United States’ Food and Drug Administration (FDA) in late 2023, we look
Aditya Bharti, Joann Mudge
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CRISPR/Cas9 Delivery System Engineering for Genome Editing in Therapeutic Applications
Pharmaceutics, 2021 The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform for gene correction, transcriptional regulation, disease modeling, and ...
Hao Cheng, Feng Zhang, Yang Ding
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Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction
Current Oncology, 2023 Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing’s rapid advancement has increased its medical/clinical value.
Ali A. Rabaan +20 more
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CRISPR/CAS9 Technologies [PDF]
Journal of Bone and Mineral Research, 2017 ABSTRACT The Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) pathway is revolutionizing biological research. Modifications to this primitive prokaryotic immune system now enable scientists to efficiently edit DNA or modulate gene expression in living ...
Bart O, Williams, Matthew L, Warman
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Current applications and future perspective of CRISPR/Cas9 gene editing in cancer
Molecular Cancer, 2022 Clustered regularly interspaced short palindromic repeats (CRISPR) system provides adaptive immunity against plasmids and phages in prokaryotes. This system inspires the development of a powerful genome engineering tool, the CRISPR/CRISPR-associated ...
Si-Wei Wang +9 more
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CRISPR/Cas genome editing in grapevine: recent advances, challenges and future prospects
Fruit Research, 2022 The development of clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system has revolutionized genome editing and plant breeding. Applications of CRISPR/Cas9 technology in fruit crops, including grapevine,
Chong Ren, Yanping Lin, Zhenchang Liang
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A Q methodology study on divergent perspectives on CRISPR-Cas9 in the Netherlands
BMC Medical Ethics, 2021 Background CRISPR-Cas9, a technology enabling modification of the human genome, is developing rapidly. There have been calls for public debate to discuss its ethics, societal implications, and governance.
Mirjam Schuijff +2 more
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CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]
, 2020 The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I +2 more
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CRISPR/Cas9 genetic screens in hepatocellular carcinoma gene discovery
Current Research in Biotechnology, 2023 The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is a powerful gene editing tool originated from prokaryotes.
Cynthia H. Chiu
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Targeted mutagenesis using CRISPR-Cas9 in the chelicerate herbivore Tetranychus urticae [PDF]
, 2020 The use of CRISPR-Cas9 has revolutionized functional genetic work in many organisms, including more and more insect species. However, successful gene editing or genetic transformation has not yet been reported for chelicerates, the second largest group ...
Dermauw, Wannes +5 more
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