Results 11 to 20 of about 254,775 (306)
CRISPR/Cas genome editing in grapevine: recent advances, challenges and future prospects
Fruit Research, 2022 The development of clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9) system has revolutionized genome editing and plant breeding. Applications of CRISPR/Cas9 technology in fruit crops, including grapevine,
Chong Ren, Yanping Lin, Zhenchang Liang
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CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.
New England Journal of Medicine, 2021 BACKGROUND Transthyretin amyloidosis, also called ATTR amyloidosis, is a life-threatening disease characterized by progressive accumulation of misfolded transthyretin (TTR) protein in tissues, predominantly the nerves and heart.
J. Gillmore +25 more
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Veterinarska stanica, 2021 CRISPR/Cas9 postala je snažna metoda za unošenje promjena u genom brojnih organizama. Prvi put otkriven u bakterijama kao dio prilagodljivog imunološkog sustava, CRISPR/Cas9 i njegove modificirane verzije u širokoj su uporabi u inženjeringu genoma i aktivaciji ili suzbijanju ekspresije gena.
Mimoune, Nora +5 more
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CRISPR/Cas9 in Gastrointestinal Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 Gastrointestinal (GI) cancers such as colorectal cancer (CRC), gastric cancer (GC), esophageal cancer (EG), pancreatic duct adenocarcinoma (PDAC) or hepatocellular cancer (HCC) belong to the most commonly diagnosed types of cancer and are among the most frequent causes of cancer related death worldwide.
Jefremow, André +2 more
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A Q methodology study on divergent perspectives on CRISPR-Cas9 in the Netherlands
BMC Medical Ethics, 2021 Background CRISPR-Cas9, a technology enabling modification of the human genome, is developing rapidly. There have been calls for public debate to discuss its ethics, societal implications, and governance.
Mirjam Schuijff +2 more
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CRISPR/Cas9 genetic screens in hepatocellular carcinoma gene discovery
Current Research in Biotechnology, 2023 The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) system is a powerful gene editing tool originated from prokaryotes.
Cynthia H. Chiu
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Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing
Journal of Nanobiotechnology, 2022 The CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering strategies to enable efficient intracellular delivery of CRISPR-Cas9 components has
Tianxu Fang +3 more
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Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras G12D in pancreatic cancer
Life Science Alliance, 2021 This work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy. CRISPR/Cas9 is a promising technology for gene editing.
Kathleen M McAndrews +5 more
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BioMed Research International, 2022 CRISPR/Cas9 technology has become the most examined gene editing technology in recent years due to its simple design, yet low cost, high efficiency, and simple operation, which can also achieve simultaneous editing of multiple loci. It can also be carried out without using plasmids, saving lots of troubles caused by plasmids.
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Truncated gRNA reduces CRISPR/Cas9-mediated off-target rate for MSTN gene knockout in bovines
Journal of Integrative Agriculture, 2019 The CRISPR/Cas9 mediates efficient gene editing but has off-target effects inconducive to animal breeding. In this study, the efficacy of CRISPR/Cas9 vectors containing different lengths of gRNA in reduction of the off-target phenomenon in the bovine ...
Zheng-wei ZHOU +7 more
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