Results 71 to 80 of about 216,936 (304)
Development of viral vectors for CRISPR-Cas9 delivery towards the eradication of HIV-1 infection.
, 2022 openIl sistema CRISPR-Cas9 è un’innovativa tecnologia adibita all’editing del DNA. Derivato da un meccanismo di difesa attuato dai batteri, il sistema CRISPR-Cas9 rappresenta una nuova frontiera nella cura di numerose patologie, in particolar modo ...
PONCATO, ELISA
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus
, 2014 European SulfoSYS-project [SysMo P–N-01-09-23] and grant [9P23000 and P25369] by the Austrian Research fund (to C.S.) and by grant [BB/K000314/1] from the Biotechnology and Biological Sciences Research Council (to M.F.W.). Funding for open access charge:
Manica, A. +4 more
core +1 more source
The tsunami named CRISPR/Cas9 [PDF]
Revue Neurologique, 2018 It is rare to witness a breakthrough technology that results in a multidimensional revolution in human health that also has impacts on animals and plants as well as biodiversity and the environment. The tsunami associated with the latest genome editing techniques is most likely not comparable to anything we have known thus far.
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Multiple nucleic acid cleavage modes in divergent type III CRISPR systems
, 2016 CRISPR-Cas is an RNA-guided adaptive immune system that protects bacteria and archaea from invading nucleic acids. Type III systems (Cmr, Csm) have been shown to cleave RNA targets in vitro and some are capable of transcription-dependent DNA targeting ...
Zhang, Jing +4 more
core +1 more source
Optimization of CRISPR/Cas9 genome editing in cotton by improved sgRNA expression
Plant Methods, 2018 Background When developing CRISPR/Cas9 systems for crops, it is crucial to invest time characterizing the genome editing efficiency of the CRISPR/Cas9 cassettes, especially if the transformation system is difficult or time-consuming.
Lu Long +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Multiplexable and Biocomputational Virus Detection by CRISPR-Cas9-Mediated Strand Displacement
, 2023 Recurrent disease outbreaks caused by different viruses, including the novel respiratory virus SARS-CoV-2, are challenging our society at a global scale; so versatile virus detection methods would enable a calculated and faster response. Here, we present
David Navarro +15 more
core +2 more sources
Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy
Cell & Bioscience, 2021 Since CRISPR/Cas9 was harnessed to edit DNA, the field of gene therapy has witnessed great advances in gene editing. New avenues were created for the treatment of diseases such as Cystic Fibrosis (CF).
Ranmal Avinash Bandara +2 more
doaj +1 more source