Insight into the natural regulatory mechanisms and clinical applications of the CRISPR-Cas system [PDF]
HeliyonCRISPR-Cas, the adaptive immune system exclusive to prokaryotes, confers resistance against foreign mobile genetic elements. The CRISPR-Cas system is now being exploited by scientists in a diverse range of genome editing applications.
Hui Cheng +7 more
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Genome editing using the endogenous type I CRISPR-Cas system in Lactobacillus crispatus [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Lactobacillus crispatus primarily inhabits 2 ecological niches: the human vagina and the poultry intestine. The predominance of this commensal species is indicative of a healthy status, and this species has become intriguing as an emerging ...
Claudio Hidalgo-Cantabrana +4 more
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Advances in Engineering the Fly Genome with the CRISPR-Cas System. [PDF]
Genetics, 2018 Drosophila has long been a premier model for the development and application of cutting-edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the genome with ease and precision, providing a rich toolbox to interrogate ...
Bier, Ethan +3 more
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CRISPR-Cas System in Antibiotic Resistance Plasmids in Klebsiella pneumoniae
Frontiers in Microbiology, 2020 CRISPR-Cas (clustered regularly interspersed short palindromic repeats-CRISPR-associated protein) is a microbial adaptive immune system involved in defense against different types of mobile genetic elements.
Muhammad Kamruzzaman +2 more
doaj +2 more sources
Using an Endogenous CRISPR-Cas System for Genome Editing in the Human Pathogen Clostridium difficile [PDF]
Applied and Environmental Microbiology, 2019 Clostridium difficile represents today a real danger for human and animal health. It is the leading cause of diarrhea associated with health care in adults in industrialized countries.
Anna Maikova +4 more
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Prevalence of the CRISPR-cas system and its association with antibiotic resistance in clinical Klebsiella pneumoniae isolates [PDF]
BMC Infectious DiseasesBackground and objective(s) CRISPR-Cas is a prokaryotic adaptive immune system that protects bacteria and archaea against mobile genetic elements (MGEs) such as bacteriophages plasmids, and transposons. In this study, we aimed to assess the prevalence of
Hiva Kadkhoda +8 more
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Efficient, compact, and versatile: Type I-F2 CRISPR-Cas system. [PDF]
mLifeMa S, Zhang S, Liu K, Hu T, Hu C.
europepmc +3 more sources
CRISPR/Cas system and its application in the diagnosis of animal infectious diseases. [PDF]
FASEB JRasool HMH, Chen Q, Gong X, Zhou J.
europepmc +3 more sources
Frontiers in Microbiology, 2023 Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) are an adaptive immune system involved in specific defenses against the invasion of foreign mobile genetic elements, such as plasmids and phages.
Shuan Tao +9 more
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Application of CRISPR/Cas Systems in the Nucleic Acid Detection of Infectious Diseases
Diagnostics, 2022 The CRISPR/Cas system is a protective adaptive immune system against attacks from foreign mobile genetic elements. Since the discovery of the excellent target-specific sequence recognition ability of the CRISPR/Cas system, the CRISPR/Cas system has shown
Junwei Li +8 more
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