Results 31 to 40 of about 75,041 (301)

Characterization of 67 Confirmed Clustered Regularly Interspaced Short Palindromic Repeats Loci in 52 Strains of Staphylococci

Frontiers in Microbiology, 2021
Staphylococcus aureus (S. aureus), which is one of the most important species of Staphylococci, poses a great threat to public health. Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) are an ...
Ying Wang, Tingting Mao, Yinxia Li, Wenwei Xiao, Xuan Liang, Guangcai Duan, Haiyan Yang   +6 more
doaj   +1 more source

Cas1 and Cas2 From the Type II-C CRISPR-Cas System of Riemerella anatipestifer Are Required for Spacer Acquisition

Frontiers in Cellular and Infection Microbiology, 2018
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins provide acquired genetic immunity against the entry of mobile genetic elements (MGEs).
Yang He, Yang He, Yang He, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mafeng Liu, Mafeng Liu, Mafeng Liu, Li Huang, Li Huang, Li Huang, Chaoyue Liu, Chaoyue Liu, Chaoyue Liu, Xin Zhang, Xin Zhang, Xin Zhang, Haibo Yi, Haibo Yi, Haibo Yi, Anchun Cheng, Anchun Cheng, Anchun Cheng, Dekang Zhu, Dekang Zhu, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shun Chen, Shun Chen, Shun Chen, Renyong Jia, Renyong Jia, Renyong Jia, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang   +52 more
doaj   +1 more source

New CRISPR–Cas systems from uncultivated microbes [PDF]

Nature, 2016
CRISPR-Cas systems provide microbes with adaptive immunity by employing short DNA sequences, termed spacers, that guide Cas proteins to cleave foreign DNA. Class 2 CRISPR-Cas systems are streamlined versions, in which a single RNA-bound Cas protein recognizes and cleaves target sequences.
Burstein, David, Harrington, Lucas B, Strutt, Steven C, Probst, Alexander J, Anantharaman, Karthik, Thomas, Brian C, Doudna, Jennifer A, Banfield, Jillian F   +7 more
openaire   +5 more sources

DNA Nanomaterials for Delivery of Clustered Regularly Interspaced Short Palindromic Repeats/Cas Systems

Small Structures, 2023
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein (CRISPR/Cas) system has been exploited as an efficient gene editing tool with precise site specificity and high efficiency; the delivery of the CRISPR/Cas system is
Zhaoyue Lv, Zhemian Li, Peiran Li, Chi Yao, Dayong Yang   +4 more
doaj   +1 more source

The virulence factor regulator and quorum sensing regulate the type I-F CRISPR-Cas mediated horizontal gene transfer in Pseudomonas aeruginosa

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is capable of thriving in diverse environments due to its network of regulatory components for effective response to stress factors.
Stephen Dela Ahator, Stephen Dela Ahator, Yang Liu, Yang Liu, Jianhe Wang, Lian-Hui Zhang   +5 more
doaj   +1 more source

Advances in Engineering the Fly Genome with the CRISPR-Cas System. [PDF]

, 2018
Drosophila has long been a premier model for the development and application of cutting-edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the genome with ease and precision, providing a rich toolbox to interrogate ...
Bier, Ethan, Harrison, Melissa M, O'Connor-Giles, Kate M, Wildonger, Jill   +3 more
core   +2 more sources

Drug Inducible CRISPR/Cas Systems

Computational and Structural Biotechnology Journal, 2019
Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems have been employed as a powerful versatile technology for programmable gene editing, transcriptional modulation, epigenetic modulation, and genome labeling, etc.
Jingfang Zhang, Li Chen, Ju Zhang, Yu Wang   +3 more
openaire   +3 more sources

Determination of Acr-mediated immunosuppression in Pseudomonas aeruginosa

MethodsX, 2023
Bacteria have a broad array of defence mechanisms to fight bacteria-specific viruses (bacteriophages, phages) and other invading mobile genetic elements. Among those mechanisms, the ‘CRISPR-Cas’ (Clustered Regularly Interspaced Short Palindromic Repeats –
Benoit J. Pons, Edze R. Westra, Stineke van Houte   +2 more
doaj   +1 more source

Efficient genome editing in zebrafish using a CRISPR-Cas system [PDF]

, 2013
In bacteria, foreign nucleic acids are silenced by clustered, regularly interspaced, short palindromic repeats (CRISPR)--CRISPR-associated (Cas) systems.
Fu, Yanfang, Hwang, Woong Y., Joung, J. Keith, Maeder, Morgan L., Peterson, Randall T., Reyon, Deepak, Sander, Jeffry D., Tsai, Shengdar Q., Yeh, J.-R. Joanna   +8 more
core   +1 more source

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes. [PDF]

, 2020
Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block ...
Doudna, Jennifer A, Fellmann, Christof, Lew, Rachel J, McMahon, Blake, Shivram, Haridha, Watters, Kyle E   +5 more
core   +3 more sources