Results 21 to 30 of about 207,049 (372)
CRISPR-Cas System: The Current and Emerging Translational Landscape
Cells, 2023 CRISPR-Cas technology has rapidly changed life science research and human medicine. The ability to add, remove, or edit human DNA sequences has transformative potential for treating congenital and acquired human diseases.
Narendranath Bhokisham +5 more
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New CRISPR-Cas systems discovered [PDF]
Cell Research, 2017 In bacteria and archaea, CRISPR-Cas adaptive immune systems utilize RNA-guided endonucleases to defend against invasion by foreign nucleic acids of bacteriophage, virus and plasmid origin. In a recent paper published in Nature, Burstein et al. identified the first Cas9 protein in uncultivated archaea and two novel CRISPR-CasX and CRISPR-CasY systems in
Hui, Yang, Dinshaw J, Patel
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CRISPR/Cas System and Factors Affecting Its Precision and Efficiency
Frontiers in Cell and Developmental Biology, 2021 The diverse applications of genetically modified cells and organisms require more precise and efficient genome-editing tool such as clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas).
Nasir Javaid, Sangdun Choi
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Carrier strategies boost the application of CRISPR/Cas system in gene therapy
Exploration, 2022 Emerging clustered regularly interspaced short palindromic repeat/associated protein (CRISPR/Cas) genome editing technology shows great potential in gene therapy.
Zunkai Xu +10 more
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Research advances on pathogenic nucleic acid detection technology based on CRIPSR/Cas system
浙江大学学报. 农业与生命科学版, 2023 Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) (CRISPR/Cas) system, an ancient bacterial and archaeal immune system, has rapidly developed into a popular gene-editing tool, which largely promotes the ...
LI Hongzhao +4 more
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Classification of CRISPR/Cas system and its application in tomato breeding
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2022 Remarkable diversity in the domain of genome loci architecture, structure of effector complex, array of protein composition, mechanisms of adaptation along with difference in pre-crRNA processing and interference have led to a vast scope of detailed ...
Abira Chaudhuri +2 more
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CRISPR-Cas systems in multicellular cyanobacteria [PDF]
RNA Biology, 2018 Novel CRISPR-Cas systems possess substantial potential for genome editing and manipulation of gene expression. The types and numbers of CRISPR-Cas systems vary substantially between different organisms. Some filamentous cyanobacteria harbor > 40 different putative CRISPR repeat-spacer cassettes, while the number of cas gene instances is much lower ...
Shengwei Hou +6 more
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CASPredict: a web service for identifying Cas proteins [PDF]
PeerJ, 2021 Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated (Cas) proteins constitute the CRISPR-Cas systems, which play a key role in prokaryote adaptive immune system against invasive foreign elements.
Shanshan Yang, Jian Huang, Bifang He
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Mechanisms regulating the CRISPR-Cas systems
Frontiers in Microbiology, 2023 The CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats- CRISPR associated proteins) is a prokaryotic system that enables sequence specific recognition and cleavage of nucleic acids. This is possible due to cooperation between CRISPR array which contains short fragments of DNA called spacers that are complimentary to the targeted ...
Marta Zakrzewska +3 more
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Application of the CRISPR/Cas System in Pathogen Detection: A Review
Molecules, 2022 Early and rapid diagnosis of pathogens is important for the prevention and control of epidemic disease. The polymerase chain reaction (PCR) technique requires expensive instrument control, a special test site, complex solution treatment steps and ...
Bowei Yuan +4 more
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