The CRISPR-Cas system as a tool for diagnosing and treating infectious diseases
Molecular Biology Reports, 2022 Emerging and relapsing infectious diseases pose a huge health threat to human health and a new challenge to global public health. Rapid, sensitive and simple diagnostic tools are keys to successful management of infectious patients and containment of ...
Juan Lou +8 more
semanticscholar +1 more source
CRISPR-Cas systems in Proteus mirabilis
Infection, Genetics and Evolution, 2021 The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a bacterial defense mechanism against bacteriophages composed of two different parts: the CRISPR array and the Cas genes. The spacer acquisition is done by the adaptation module consisting of the hallmark Cas1 Cas2 proteins, which inserts new spacers into the CRISPR array.
Mahnaz Shafaei, Fallah +3 more
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Insight into the molecular mechanism of the transposon-encoded type I-F CRISPR-Cas system
Journal of Genetic Engineering and Biotechnology, 2023 CRISPR-Cas9 is a popular gene-editing tool that allows researchers to introduce double-strand breaks to edit parts of the genome. CRISPR-Cas9 system is used more than other gene-editing tools because it is simple and easy to customize.
Amnah Alalmaie +2 more
doaj +1 more source
Frontiers in Plant Science, 2022 Different genome editing approaches have been used to engineer resistance against plant viruses. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas; CRISPR/Cas) systems to create pinpoint genetic ...
Fredy D. A. Silva +1 more
doaj +1 more source
Association between the presence of CRISPR-Cas system genes and antibiotic resistance in Klebsiella pneumoniae isolated from patients admitted in Ahvaz teaching hospitals. [PDF]
BMC Infect DisMontazeri EA +4 more
europepmc +3 more sources
Genome editing with the CRISPR‐Cas system: an art, ethics and global regulatory perspective
Plant Biotechnology Journal, 2020 Summary Over the last three decades, the development of new genome editing techniques, such as ODM, TALENs, ZFNs and the CRISPR‐Cas system, has led to significant progress in the field of plant and animal breeding.
Debin Zhang +9 more
semanticscholar +1 more source
CRISPR-Cas System: A Tool to Eliminate Drug-Resistant Gram-Negative Bacteria
Pharmaceuticals, 2022 Rapidly emerging drug-resistant superbugs, especially Gram-negative bacteria, pose a serious threat to healthcare systems all over the globe. Newer strategies are being developed to detect and overcome the arsenal of weapons that these bacteria possess ...
Rajeshwari Kundar, K. Gokarn
semanticscholar +1 more source
Using CRISPR-Cas systems as antimicrobials [PDF]
Current Opinion in Microbiology, 2017 Although CRISPR-Cas systems naturally evolved to provide adaptive immunity in bacteria and archaea, Cas nucleases can be co-opted to target chromosomal sequences rather than invasive genetic elements. Although genome editing is the primary outcome of self-targeting using CRISPR-based technologies in eukaryotes, self-targeting by CRISPR is typically ...
Bikard, David, Barrangou, Rodolphe
openaire +3 more sources
Development and Application of CRISPR/Cas System in Rice
Rice Science, 2019 In the past several years, the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) system has been harnessed as an efficient and powerful tool for targeted genome editing in different prokaryotic and ...
Ren Jun +3 more
doaj +1 more source
A Newly Discovered Bordetella Species Carries a Transcriptionally Active CRISPR-Cas with a Small Cas9 Endonuclease [PDF]
, 2015 Background Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (cas) are widely distributed among bacteria.
Dudley, Edward G. +7 more
core +2 more sources