Results 41 to 50 of about 216,867 (346)

Phylogenetic Distribution of CRISPR-Cas Systems in Staphylococcus lugdunensis

Microbiology Spectrum, 2021
Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) genes (CRISPR-Cas) are present in many bacterial genomes with functions beyond adaptive immunity.
Cheng-Yen Kao, Jang-Jih Lu, Lee-Chung Lin, Hsiao-Chi Lin, Shih-Cheng Chang   +4 more
doaj   +1 more source

Physical Model of the Immune Response of Bacteria Against Bacteriophage Through the Adaptive CRISPR-Cas Immune System [PDF]

, 2013
Bacteria and archaea have evolved an adaptive, heritable immune system that recognizes and protects against viruses or plasmids. This system, known as the CRISPR-Cas system, allows the host to recognize and incorporate short foreign DNA or RNA sequences,
Barrick, Jeffrey E., Deem, Michael W., Han, Pu, Niestemski, Liang Ren   +3 more
core   +1 more source

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes. [PDF]

, 2020
Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block ...
Doudna, Jennifer A, Fellmann, Christof, Lew, Rachel J, McMahon, Blake, Shivram, Haridha, Watters, Kyle E   +5 more
core   +3 more sources

Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein

mBio, 2017
CRISPR (clustered regularly interspaced short palindromic repeat)-Cas adaptive immune systems are prevalent defense mechanisms in bacteria and archaea.
April Pawluk, Megha Shah, Marios Mejdani, Charles Calmettes, Trevor F. Moraes, Alan R. Davidson, Karen L. Maxwell   +6 more
doaj   +1 more source

Characterization of 67 Confirmed Clustered Regularly Interspaced Short Palindromic Repeats Loci in 52 Strains of Staphylococci

Frontiers in Microbiology, 2021
Staphylococcus aureus (S. aureus), which is one of the most important species of Staphylococci, poses a great threat to public health. Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-associated proteins (Cas) are an ...
Ying Wang, Tingting Mao, Yinxia Li, Wenwei Xiao, Xuan Liang, Guangcai Duan, Haiyan Yang   +6 more
doaj   +1 more source

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

Nucleic Acids Research, 2013
The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with desired properties.
David Bikard, Wenyan Jiang, Poulami Samai, A. Hochschild, Feng Zhang, L. Marraffini   +5 more
semanticscholar   +1 more source

Cas1 and Cas2 From the Type II-C CRISPR-Cas System of Riemerella anatipestifer Are Required for Spacer Acquisition

Frontiers in Cellular and Infection Microbiology, 2018
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins provide acquired genetic immunity against the entry of mobile genetic elements (MGEs).
Yang He, Yang He, Yang He, Mingshu Wang, Mingshu Wang, Mingshu Wang, Mafeng Liu, Mafeng Liu, Mafeng Liu, Li Huang, Li Huang, Li Huang, Chaoyue Liu, Chaoyue Liu, Chaoyue Liu, Xin Zhang, Xin Zhang, Xin Zhang, Haibo Yi, Haibo Yi, Haibo Yi, Anchun Cheng, Anchun Cheng, Anchun Cheng, Dekang Zhu, Dekang Zhu, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Shun Chen, Shun Chen, Shun Chen, Renyong Jia, Renyong Jia, Renyong Jia, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang   +52 more
doaj   +1 more source

The virulence factor regulator and quorum sensing regulate the type I-F CRISPR-Cas mediated horizontal gene transfer in Pseudomonas aeruginosa

Frontiers in Microbiology, 2022
Pseudomonas aeruginosa is capable of thriving in diverse environments due to its network of regulatory components for effective response to stress factors.
Stephen Dela Ahator, Stephen Dela Ahator, Yang Liu, Yang Liu, Jianhe Wang, Lian-Hui Zhang   +5 more
doaj   +1 more source

New CRISPR–Cas systems from uncultivated microbes [PDF]

Nature, 2016
CRISPR-Cas systems provide microbes with adaptive immunity by employing short DNA sequences, termed spacers, that guide Cas proteins to cleave foreign DNA. Class 2 CRISPR-Cas systems are streamlined versions, in which a single RNA-bound Cas protein recognizes and cleaves target sequences.
Burstein, David, Harrington, Lucas B, Strutt, Steven C, Probst, Alexander J, Anantharaman, Karthik, Thomas, Brian C, Doudna, Jennifer A, Banfield, Jillian F   +7 more
openaire   +5 more sources

DNA Nanomaterials for Delivery of Clustered Regularly Interspaced Short Palindromic Repeats/Cas Systems

Small Structures, 2023
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein (CRISPR/Cas) system has been exploited as an efficient gene editing tool with precise site specificity and high efficiency; the delivery of the CRISPR/Cas system is
Zhaoyue Lv, Zhemian Li, Peiran Li, Chi Yao, Dayong Yang   +4 more
doaj   +1 more source