Results 201 to 210 of about 18,104 (240)

Staufen‐2 functions as a cofactor for enhanced Rev‐mediated nucleocytoplasmic trafficking of HIV‐1 genomic RNA via the CRM1 pathway

The FEBS Journal, 2022
Nucleocytoplasmic shuttling of viral elements, supported by several host factors, is essential for the replication of the human immunodeficiency virus (HIV).
K. Balakrishnan, Punnagai Munusami, Krishnaveni Mohareer, U. Priyakumar, A. Banerjee, Tom Luedde, S. Mande, C. Münk, Sharmistha Banerjee   +8 more
semanticscholar   +1 more source

Chromosome Region Maintenance 1 (XPO1/CRM1) as an Anticancer Target and Discovery of Its Inhibitor.

Journal of Medicinal Chemistry, 2021
Chromosome region maintenance 1 (CRM1) is a major nuclear export receptor protein and contributes to cell homeostasis by mediating the transport of cargo from the nucleus to the cytoplasm.
Song Liu, Wenlian Qiao, Qingxiang Sun, Youfu Luo   +3 more
semanticscholar   +1 more source

CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity

Blood, 2011
Abstract CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. Leptomycin B (LMB), a well-known CRM1 inhibitor, possesses strong antitumor properties. However, its toxicity prevents it from being clinically useful.
Keiichi, Sakakibara, Naoya, Saito, Takuji, Sato, Atsushi, Suzuki, Yoko, Hasegawa, Jonathan M, Friedman, Donald W, Kufe, Daniel D, Vonhoff, Tadahiko, Iwami, Takumi, Kawabe   +9 more
openaire   +3 more sources

Atomic basis of CRM1-cargo recognition, release and inhibition [PDF]

Seminars in Cancer Biology, 2014
CRM1 or XPO1 is the major nuclear export receptor in the cell, which controls the nuclear-cytoplasmic localization of many proteins and RNAs. CRM1 is also a promising cancer drug target as the transport receptor is overexpressed in many cancers where some of its cargos are misregulated and mislocalized to the cytoplasm.
Ho Yee Joyce Fung, Yuh Min Chook
exaly   +3 more sources

Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.

Journal of Natural Products, 2021
The protein chromosome region maintenance 1 (CRM1) is an important nuclear export factor and drug target in diseases such as cancer and viral infections.
Y. Lei, Yuling Li, Yuping Tan, Z. Qian, Qiao Zhou, Da Jia, Qingxiang Sun   +6 more
semanticscholar   +1 more source

Cellular Requirements for CRM1 Import and Export

Journal of Biochemistry, 2003
We studied the cellular requirements for the translocation of CRM1 (exportin 1) between the nucleus and the cytoplasm. CRM1 import requires neither ATP, Ran, Ran-dependent GTP hydrolysis, nor a particular temperature. CRM1 and importin beta compete with each other during their import.
Xianfeng, Zhang, Masami, Yamada, Naoto, Mabuchi, Hisatoshi, Shida   +3 more
openaire   +2 more sources

CRM1 expression in pancreatic carcinoma.

Journal of Clinical Oncology, 2013
e15115 Background: Increased expression of chromosomal region maintenance (CRM1) protein, also known as exportin 1, has been described in several human cancers. It is an important regulator of subcellular localization of tumor suppressor proteins and growth regulatory proteins. Direct inhibition of CRM1 blocks cell proliferation and induces apoptosis
Amit Mahipal, Domenico Coppola, Shilpa Gupta, Barbara Centeno, Mokenge Peter Malafa   +4 more
openaire   +1 more source

ZAP is a CRM1-dependent nucleocytoplasmic shuttling protein

Biochemical and Biophysical Research Communications, 2004
The zinc finger antiviral protein (ZAP) is a recently isolated host antiviral factor. It specifically inhibits the replication of Moloney murine leukemia virus (MMLV) and Sindbis virus (SIN) by preventing the accumulation of viral RNA in the cytoplasm.
Lixin, Liu, Guifang, Chen, Xin, Ji, Guangxia, Gao   +3 more
openaire   +2 more sources

Characterization of inhibition reveals distinctive properties for human and Saccharomyces cerevisiae CRM1.

Journal of Medicinal Chemistry, 2020
The receptor CRM1 is responsible for the nuclear export of many tumor-suppressor proteins and viral ribonucleoproteins. This renders CRM1 an interesting target for therapeutic intervention in diverse cancer types and viral diseases. Structural studies of
A. Shaikhqasem, A. Dickmanns, P. Neumann, R. Ficner   +3 more
semanticscholar   +1 more source

Domains of Crm1 Involved in the Formation of the Crm1, RanGTP, and Leucine-Rich Nuclear Export Sequences Trimeric Complex

Experimental Cell Research, 1999
Nuclear export of proteins containing a leucine-rich nuclear export sequence (NES) is mediated by a specific NES receptor known as Crm1. This protein, which is related to the karyopherin beta family, interacts directly with NES in a RanGTP-dependent manner.
B, Ossareh-Nazari, C, Dargemont
openaire   +2 more sources