Results 211 to 220 of about 18,104 (240)
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CRM1 mediates the nuclear export of YTHDF2
Biochemical and Biophysical Research CommunicationsPrecise intracellular localization is crucial for protein function. YTHDF2, a reader protein for N6-methyladenosine (m6A), has been reported to shuttle between the cytoplasm and nucleus through an unknown mechanism. Here, we identify a functional nuclear export sequence (NES) in YTHDF2 that mediates its nuclear export.
Shumei Wei +5 more
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Regulation of Crm1 expression in cancer cells
Clinical Cancer Research, 2010Abstract Crm1 (or exportin 1) is a member of the karyopherin β protein family that mediates the nuclear export of cargo proteins and certain RNAs from the nucleus into the cytoplasm. We previously identified increased expression of Crm1 mRNA and protein in cervical tumours compared to normal epithelium, and increased Crm1 expression in ...
Pauline J. van der Watt, Virna D. Leaner
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CRM1-mediated nuclear export: to the pore and beyond
Trends in Cell Biology, 2007CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs.
Ralph H Kehlenbach
exaly +3 more sources
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1
Experimental Cell Research, 2003In addition to previously isolated ratjadone A we describe three new members of this family, ratjadones B, C, and D, from another strain of the myxobacterium Sorangium cellulosum. We have investigated the properties of these ratjadones with respect to their activity on mammalian cell lines.
Köster, Mario +8 more
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A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27.
European journal of medicinal chemistry, 2020Chromosome region maintenance 1 (CRM1) is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer drug target.
Hai-wei Xu +8 more
semanticscholar +1 more source
CRM1 mediates ASC nuclear export and inflammasome activation
International ImmunopharmacologyInflammasomes are multiprotein complexes of the innate immune system that sense different pathogens or danger signals, and have been implicated in the pathogenesis of multiple human inflammatory diseases. The translocation of adaptor protein ASC from the nucleus to the cytosol is important for inflammasome assembly and activation, but the mechanism ...
Rui, Cao +6 more
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CRM1 as a new therapeutic target for non-Hodgkin lymphoma
Leukemia Research, 2015The chromosomal region maintenance 1 (CRM1) may serve as a novel target for cancer treatment. Here, we investigated the anti non-Hodgkin lymphoma (NHL) activity of two novel CRM1 inhibitors (KPT-185 and KPT-276) in vitro and in vivo. KPT-185 displayed potent antiproliferative properties and induced cell-cycle arrest and apoptosis in several NHL cell ...
Xiaohong, Han +6 more
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Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1.
Methods in molecular biology, 2022H. Fung, Y. Chook
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Analysis of CRM1-Dependent Nuclear Export in Permeabilized Cells
2016Nuclear protein import and export assays in permeabilized cells have been instrumental for the identification of transport factors and for the molecular characterization of nucleocytoplasmic transport pathways. Our original assay to quantitatively analyze CRM1-dependent export was based on stably transfected cells expressing GFP-NFAT.
Ralph H, Kehlenbach, Sarah A, Port
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