Results 101 to 110 of about 3,047 (190)
Cell Death Discovery, 2022 Dysfunction of ionotropic glutamate receptors (iGluRs) is a key molecular mechanism of excitotoxic neuronal injury following traumatic brain injury (TBI).
Tao Chen +5 more
doaj +1 more source
Poly-arginine peptide R18D reduces neuroinflammation and functional deficits following traumatic brain injury in the Long-Evans rat [PDF]
, 2019 We have previously demonstrated that the poly-arginine peptide R18 can improve histological and functional outcomes following traumatic brain injury (TBI) in the Sprague–Dawley rat.
Anderton, Ryan S +5 more
core +1 more source
PAK in Alzheimer disease, Huntington disease and X-linked mental retardation. [PDF]
, 2012 Developmental cognitive deficits including X-linked mental retardation (XLMR) can be caused by mutations in P21-activated kinase 3 (PAK3) that disrupt actin dynamics in dendritic spines.
Cole, Greg M +3 more
core +1 more source
Epilepsia, Volume 66, Issue 5, Page 1599-1612, May 2025.Abstract Objective Subjects with left temporal lobe epilepsy may either show altered hemispheric language lateralization or retain typical, left lateralization. Examining the integrity of white matter pathways involved in the adaptation or maintenance of language lateralization in these patients could have important clinical implications for preserving
Salvatore Citro +7 more
wiley +1 more source
Acta Neuropathologica Communications, 2020 The accumulation of phosphorylated tau protein (pTau) in the entorhinal cortex (EC) is the earliest tau pathology in Alzheimer’s disease (AD). Tau tubulin kinase-1 (TTBK1) is a neuron-specific tau kinase and expressed in the EC and hippocampal regions in
Seiko Ikezu +5 more
doaj +1 more source
Cell Communication and Signaling, 2023 Elraglusib (formerly 9-ING-41) is an ATP-competitive inhibitor of glycogen synthase kinase-3β (GSK3β) undergoing clinical trials for the treatment of various cancers including non-Hodgkin lymphoma (NHL). The drug reduces proliferation of several NHL cell
Josh T. Coats +2 more
doaj +1 more source
Deciphering the role of sphingosine 1‐phosphate in central nervous system myelination and repair
Journal of Neurochemistry, Volume 169, Issue 1, January 2025.Sphingosine‐1‐phosphate (S1P) signals to a family of five S1P receptors 1–5 (S1PR1–5) coupled with different G proteins. Current studies indicate that S1P exerts differential effects on oligodendrocytes (OLG) and myelin depending on the receptor being activated: promoting the survival of oligodendrocyte precursor cells (OPC) via activating S1PR1 whilst
Fatima Binish, Junhua Xiao
wiley +1 more source
International Journal of Clinical Practice, Volume 2025, Issue 1, 2025.Purpose: Calcitonin gene‐related peptide (CGRP) is a key peptide released during trigeminal system‐initiated migraine attacks. Evidence suggests that lacosamide can inhibit CGRP release. This study aimed to assess the effectiveness of lacosamide in patients with chronic migraine. Methods: This double‐blind, randomized clinical study involved 83 chronic
Mobina Mirhosseini +4 more
wiley +1 more source
Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model [PDF]
, 2016 Background: We recently reported that poly-arginine peptides have neuroprotective properties both in vitro and in vivo. In cultured cortical neurons exposed to glutamic acid excitotoxicity, we demonstrated that neuroprotective potency increases with ...
Anderton, R +5 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.Here, we enrolled 3959 PD patients and 2931 healthy controls, categorized into two cohorts: the sporadic early Parkinson's disease & familial Parkinson's disease (sEOPD & FPD) cohort and the sporadic late Parkinson's disease (sLOPD) cohort, to identify the role of 17 Neurite Outgrowth Inhibitor‐associated genes.
Xiurong Huang +12 more
wiley +1 more source