Results 101 to 110 of about 3,056 (192)
CNS Neuroscience &Therapeutics, Volume 30, Issue 10, October 2024.Here, we enrolled 3959 PD patients and 2931 healthy controls, categorized into two cohorts: the sporadic early Parkinson's disease & familial Parkinson's disease (sEOPD & FPD) cohort and the sporadic late Parkinson's disease (sLOPD) cohort, to identify the role of 17 Neurite Outgrowth Inhibitor‐associated genes.
Xiurong Huang +12 more
wiley +1 more source
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief [PDF]
Channels, 2019 We have previously reported that the microtubule-associated collapsin response mediator protein 2 (CRMP2) is necessary for the expression of chronic pain. CRMP2 achieves this control of nociceptive signaling by virtue of its ability to regulate voltage-gated calcium and sodium channels. To date, however, no drugs exist that target CRMP2.
Aubin Moutal +6 more
openaire +2 more sources
Acta Neuropathologica Communications, 2020 The accumulation of phosphorylated tau protein (pTau) in the entorhinal cortex (EC) is the earliest tau pathology in Alzheimer’s disease (AD). Tau tubulin kinase-1 (TTBK1) is a neuron-specific tau kinase and expressed in the EC and hippocampal regions in
Seiko Ikezu +5 more
doaj +1 more source
Brain‐X, Volume 2, Issue 3, September 2024.An update for molecular basis and treatment: The major posttranslational modification (PTM) changes and crosstalk in the evolution of retinal degenerative disorders including glaucoma, diabetic retinopathy (DR), age‐related macular degeneration and myopia retinopathy.
Ke Yao +3 more
wiley +1 more source
Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells
Neural Plasticity, 2021 The present research investigates the molecular mechanism of neurite outgrowth (protrusion elongation) under pituitary adenylate cyclase-activating polypeptide (PACAP) 38 treatments using a rat adrenal-derived pheochromocytoma cell line—PC12.
Junko Shibato +7 more
doaj +1 more source
Hippocampus, Volume 34, Issue 9, Page 491-502, September 2024.Abstract Hippocampal area CA2 has garnered attention in recent times owing to its significant involvement in social memory and distinctive plasticity characteristics. Research has revealed that the CA2 region demonstrates a remarkable resistance to plasticity, particularly in the Schaffer Collateral (SC)‐CA2 pathway.
Maria Vazquez Pavon +2 more
wiley +1 more source
Chinese Medical Journal, 2015 Background: Collapsin response mediator protein-2 (CRMP2), a multifunctional cytosolic protein highly expressed in the brain, is degraded by calpain following traumatic brain injury (TBI), possibly inhibiting posttraumatic neurite regeneration.
Yun Yu +3 more
doaj +1 more source
Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]
, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin +9 more
core +2 more sources
Macrophage plasticity: signaling pathways, tissue repair, and regeneration
MedComm, Volume 5, Issue 8, August 2024.The rapid and orderly process of wound healing depends on the normal function of M1 and M2 and timely phenotypic transformation. However, when M1 phenotype is overexpressed or phenotypic transformation is delayed, it often leads to the pathological healing process of the wound. Abstract Macrophages are versatile immune cells with remarkable plasticity,
Lingfeng Yan +8 more
wiley +1 more source
Recruitment, Retainment, and Biomarkers of Response:A Pilot Trial of Lithium in Humans With Mild Cognitive Impairment [PDF]
, 2019 Lithium has been used for decades to treat Bipolar Disorder. Some of its therapeutic benefits may be through inhibition of Glycogen Synthase Kinase (GSK)-3. Enhanced GSK3 activity associates with development of Alzheimer’s disease (AD), therefore lithium
Duthie, Ashleigh +7 more
core +2 more sources