Results 81 to 90 of about 2,727 (153)

Comparison of the effects of crocetin and crocin on myocardial injury in rats

open access: yes, 2009
AIM: To compare the effects of crocetin and crocin on myocardial injury in rats. METHODS: In vitro, the myocardial cells injured by low glucose and hypoxia were treated with serum from rats given crocetin (50 mg·kg -1)or crocin(150 mg·kg-1).
Chen, Zhen   +5 more
core   +1 more source

Design and optimization of crocetin loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to preclinical study

open access: yesDrug Delivery, 2019
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus whose expand process is linked with the fibrosis, renal hypertrophy and inflammation.
Xiaodong Yang
doaj   +1 more source

Sulfone-Mediated Syntheses of Crocetin Derivatives: Regioselectivity of Highly Functionalized Building Blocks

open access: yes, 2016
New C5 sulfone building blocks containing a masked polar end group have been devised for the efficient synthesis of carotenoids with polar termini.
Jung-Ah Seo (1804126)   +5 more
core   +1 more source

Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model

open access: yesPharmaceuticals
Orally administered crocin rapidly and efficiently rescues depressive-like behaviors in depression models; however, crocin levels in the circulatory and central nervous systems are rather low.
Fan Xiao   +3 more
doaj   +1 more source

CsCCD2 Access Tunnel Design for a Broader Substrate Profile in Crocetin Production

open access: yes
Crocetin, a high-value apocarotenoid in saffron, is widely applied to the fields of food and medicine. However, the existing method of obtaining crocetin through large-scale cultivation is far from meeting the market demand.
Wen-Hai Xiao (758673)   +8 more
core   +1 more source

Evaluation of Crocetin as a Protective Agent in High Altitude Hypoxia-Induced Organ Damage

open access: yesPharmaceuticals
Crocetin is an aglycone of crocin naturally occurring in saffron and has been proved to have antioxidant, anti-inflammatory, and antibacterial activities. In this experiment, the protective effect of crocetin on vital organs in high-altitude hypoxia rats
Jun Yang   +7 more
doaj   +1 more source

Rapid Determination of Crocetin Esters and Picrocrocin from Saffron Spice (Crocus sativus L.) Using UV–Visible Spectrophotometry for Quality Control

open access: yes, 2016
The aim of this work was the development of multivariate models able to determine the content of the main crocetin esters and picrocrocin from spectrophotometric data that could be used for routine quality control of saffron.
Amaya Zalacain (2439310)   +5 more
core   +1 more source

Inhibition of protein kinase C and Proto-oncogene expression by crocetin in NIH3T3 cells

open access: yes, 2009
  Crocetin, a carotenoid isolated from the seeds of Gardenia jasminoides , was found to be a potent inhibitor of tumor promotion induced by TPA in mouse skin.
WANG, CHAU-JONG;CHENG, TZU-CHUN;LIU, JER-YUH;CHOU, FEN-PI;KUO, MIN-LIANG;LIN, JEN-KUN   +1 more
core  

The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial

open access: yes, 2019
The prevalence of myopia has been increasing in recent years. The natural carotenoid crocetin has been reported to suppress experimental myopia in mice. We evaluated the effects of crocetin on myopia suppression in children.
Kiwako Mori   +9 more
core   +1 more source

Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat

open access: yes, 2018
Background & Objective: Crocetin, an active ingredient of saffron, has been recognized as a potent antioxidant. Plant extracts or their components may be useful in ameliorating the various diseases, including neurodegenerative disorders. This study
Fariborz Samini   +3 more
core   +1 more source

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