Results 61 to 70 of about 2,019 (128)

Pharmacological Properties of Crocetin and Crocin (Digentiobiosyl Ester of Crocetin) from Saffron

Natural Product Communications, 2006
Functional plant foods and medicinal herbs provide a wide variety of natural products for new drug research and development. Crocetin and crocin (digentiobiosyl ester of crocetin) are the major bioactive ingredients of saffron which is used as a costly ...
Liang Xi, Zhiyu Qian
doaj   +1 more source

Synthesis of crocetin derivatives and their potent inhibition in multiple tumor cells proliferation and inflammatory property of macrophage

BMC Complementary Medicine and Therapies, 2020
Background Crocetin is a major active component of saffron, which has a wide range of pharmacological effects. However, due to its low solubility, the pharmacological effects of crocetin cannot be better utilized.
Mao-Ze Wang, Jin Gao, Yang Chu, Jie Niu, Ming Chen, Qiang Shang, Li-Hua Peng, Zhi-Hong Jiang   +7 more
doaj   +1 more source

Design and optimization of crocetin loaded PLGA nanoparticles against diabetic nephropathy via suppression of inflammatory biomarkers: a formulation approach to preclinical study

Drug Delivery, 2019
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus whose expand process is linked with the fibrosis, renal hypertrophy and inflammation.
Xiaodong Yang
doaj   +1 more source

Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption

Metabolites
The therapeutic effects of saffron have been reported and described in relation to its major derivatives. Among them, in terms of saffron’s properties, crocin and crocetin absorption and bioavailability have been the most studied.
Adeline Vignault, Carole Vaysse, Karène Bertand, Stéphanie Krisa, Arnaud Courtois, Benjamin Moras, Tristan Richard, David Gaudout, Line Pourtau   +8 more
doaj   +1 more source

Complete microbial synthesis of crocetin and crocins from glycerol in Escherichia coli

Microbial Cell Factories
Background Crocin, a glycosylated apocarotenoid pigment predominantly found in saffron, has garnered significant interest in the field of biotechnology for its bioactive properties.
Jun Ho Lee, Seong-Rae Lee, Sang Yup Lee, Pyung Cheon Lee   +3 more
doaj   +1 more source

Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model

Pharmaceuticals
Orally administered crocin rapidly and efficiently rescues depressive-like behaviors in depression models; however, crocin levels in the circulatory and central nervous systems are rather low.
Fan Xiao, Yulong Song, Guangji Wang, Jiye Aa   +3 more
doaj   +1 more source

Evaluation of Crocetin as a Protective Agent in High Altitude Hypoxia-Induced Organ Damage

Pharmaceuticals
Crocetin is an aglycone of crocin naturally occurring in saffron and has been proved to have antioxidant, anti-inflammatory, and antibacterial activities. In this experiment, the protective effect of crocetin on vital organs in high-altitude hypoxia rats
Jun Yang, Kai Luo, Ziliang Guo, Renjie Wang, Qingyuan Qian, Shuhe Ma, Maoxing Li, Yue Gao   +7 more
doaj   +1 more source

Antibiofilm activity of carotenoid crocetin against Staphylococcal strains

Frontiers in Cellular and Infection Microbiology
Staphylococcus aureus and Staphylococcus epidermidis stand as notorious threats to human beings owing to the myriad of infections they cause. The bacteria readily form biofilms that help in withstanding the effects of antibiotics and the immune system ...
Saurav Paramanya, Jin-Hyung Lee, Jintae Lee   +2 more
doaj   +1 more source

Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB

The Saudi Journal of Gastroenterology, 2009
Background/Aim: Ulcerative colitis (UC) is characterized by oxidative and nitrosative stress, leukocyte infiltration and upregulation of proinflammatory cytokines. In this study, we aim to investigate the effects of crocetin and its protective mechanism
Kazi Hamid, Qian Zhiyu
doaj  

Saffron as a Retinal Neuroprotectant: A Narrative Review of Preclinical Studies and Clinical Results. [PDF]

Antioxidants (Basel)
Maggi MA, Mastromartino R, Piccardi M, Minnella AM, Marangoni D, Di Marco S, Falsini B, Bisti S.   +7 more
europepmc   +1 more source