Results 61 to 70 of about 2,727 (153)

Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I

Cell Death and Disease, 2023
Parthanatos is one of the major pathways of programmed cell death in ischemic stroke characterized by DNA damage, poly (ADP-ribose) polymerases (PARP) activation, and poly (ADP-ribose) (PAR) formation.
Hao Wu, Ying Li, Qian Zhang, Hanxun Wang, Wenyu Xiu, Pu Xu, Yujie Deng, Wanxu Huang, Dan Ohtan Wang   +8 more
doaj   +1 more source

Comprehensive Evaluation of Fructus Tsaoko, Seeds of Tsaoko Fructus and Ginger Made Seeds of Tsaoko Fructus Based on Drug‐Like Compounds and Aroma Analysis

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This study mainly consists of two parts. First, after screening for drug‐like metabolites via LC–MS and GC–MS, a comprehensive evaluation model was established using a principal component analysis‐based weighted scoring method, by which the drug‐likeness ranking of three samples was determined.
Han Chen, Meiquan Yang, Weize Yang, Mingju Qi, Zongliang Xu, Tianmei Yang, Jinyu Zhang   +6 more
wiley   +1 more source

Saffron Alters Microbial Amino Acid Metabolism and Neurotransmitter Production in a Defined Gut Consortium

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Graphical representation of the metabolic pathways modulated by saffron within defined microbial communities. In the tryptophan pathway, saffron decreased levels of tryptophan and anthranilic acid while increasing concentrations of indole‐3‐acetic acid and tryptamine.
Adelaide E. Horvath, Makenna Grozis, Paul R. S. Baker, Santosh Kapil Kumar Gorti, Robert Proos, Ahmad Imran, Hassan Brim, Thomas D. Horvath, Melinda A. Engevik, Hassan Ashktorab   +9 more
wiley   +1 more source

Chemistry, biochemistry, and mechanism of pharmacological actions of crocetin

Crocetin is an important naturally occurring substance that belongs to the carotenoids and is produced by few plant species. Among these plants, Crocus sativus (Saffron) is a rich source of crocetin and its conjugated compounds known as crocins.
Al-Babili, Salim, Zeb, Alam
core   +1 more source

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source

Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells

Cellular Physiology and Biochemistry, 2016
Background/Aim: Crocetin is a readily bioavailable and bioactive compound extracted from Saffron. Previous studies indicated its various biomedical properties including antioxidant and anti-coagulation potencies.
Lei Song, Chen Kang, Yuan Sun, Wenrui Huang, Wei Liu, Zhiyu Qian   +5 more
doaj   +1 more source

Combined Analysis of Transcriptome and Metabolome Explains the Differences in Pulp Color in Jackfruit

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT The pulp color of jackfruit reflects variations in its nutritional composition and influences market preference. We investigated the mechanism underlying pulp coloration through an integrated transcriptomic and metabolomic analysis of three jackfruit cultivars—light yellow “THA”, yellow “GTM”, and orange “YNH”.
Jianjun Liang, Xiangwei Ma, Chenxin Yi, Hailan Zhou, Zhuangmin Wei, Xiuguan Tang, Weiyan Ye, Hailing Tang, Pengjin Zhu   +8 more
wiley   +1 more source

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Frontiers in Pharmacology, 2019
Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury.
Yue Zhang, Jianliang Geng, Yu Hong, Li Jiao, Shuning Li, Runbin Sun, Yuan Xie, Caixia Yan, Jiye Aa, Guangji Wang   +9 more
doaj   +1 more source

Oral Administration of Crocus sativus Tepals Extract Restores High‐Fat Diet‐Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid Metabolism

BioFactors, Volume 52, Issue 1, January/February 2026.
This study shows that oral administration of Crocus sativus tepals extract (CTE) restores gut microbiota composition and promotes SCFA‐producing and anti‐inflammatory bacterial genera. It improves intestinal barrier integrity and reduces inflammation in the jejunum and liver, suggesting a possible link between the gut microbiota and the metabolic ...
Biljana Bursać, Miloš Vratarić, Ljupka Gligorovska, Luisa Bellachioma, Ana Teofilović, Danijela Vojnović Milutinović, Camilla Morresi, Elisabetta Damiani, Tiziana Bacchetti, Ana Djordjevic   +9 more
wiley   +1 more source

The effect of Crocetin on cholesterol depletion-mediated lipid raft disruption-induced apoptosis in breast cancer cells

International Journal of Secondary Metabolite
The purpose of this study was to determine the effect of lipid raft function loss due to depletion of cholesterol in the lipid raft structure of cell membrane by crocetin and Methyl β cyclodextrin (MβCD) on cell viability and lipid raft-associated gene ...
Esma Özmen, Serife Buket Bozkurt Polat
doaj   +1 more source