Results 51 to 60 of about 2,019 (128)

In vivo and in vitro Approach to Anti-arthritic and Anti-inflammatory Effect of Crocetin by Alteration of Nuclear Factor-E2-Related Factor 2/hem Oxygenase (HO)-1 and NF-κB Expression

Frontiers in Pharmacology, 2018
Crocetin (apo carotenoid dicarboxylic acid) is a common constituent of saffron. Its importance is well documented in Chinese medicine. Some studies have reported the inhibitory effect on inflammation in rats.
Yi Li, Rajat Kakkar, Jian Wang
doaj   +1 more source

Novel plant cell suspension platforms for saffron apocarotenoid production and its impact on carotenoid and volatile profiles

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3903-3918, September 2025.
Summary Saffron apocarotenoids, including crocins, picrocrocin and safranal, are valuable metabolites with pharmaceutical and cosmetic potential. However, their natural plant sources are difficult to cultivate, which limits large‐scale production. The identification of carotenoid cleavage dioxygenases (CCDs), which catalyse the first and most critical ...
Maria Lobato‐Gómez, Markus Laurel, Marta Vázquez‐Vilar, José L. Rambla, Diego Orzáez, Heiko Rischer, Antonio Granell   +6 more
wiley   +1 more source

An evolutionarily diverged CCD4 enzyme negatively regulates mesocotyl elongation in rice

New Phytologist, Volume 249, Issue 4, Page 1569-1579, February 2026.
Yasha Zhang, Abdugaffor Ablazov, Aparna Balakrishna, Chakravarthy Rajan, Yagiz Alagoz, Kit Xi Liew, Lamis Berqdar, Jian You Wang, Ikram Blilou, Xiongjie Zheng, Salim Al‐Babili   +10 more
wiley   +1 more source

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice

Immunity & Ageing, 2018
Background Crocetin, an agent derived from saffron, has multiple pharmacological properties, such as neuroprotective, anti-oxidant, and anti-inflammatory actions. These properties might benefit the treatment of Alzheimer’s disease (AD).
Jin Zhang, Yuchao Wang, Xueshuang Dong, Jianghua Liu   +3 more
doaj   +1 more source

Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota

Frontiers in Pharmacology, 2019
Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury.
Yue Zhang, Jianliang Geng, Yu Hong, Li Jiao, Shuning Li, Runbin Sun, Yuan Xie, Caixia Yan, Jiye Aa, Guangji Wang   +9 more
doaj   +1 more source

First Insights Into the LC‐HRMS Profiling and Biological Activities of Crocus graveolens

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
This study reports the first comprehensive analysis of Crocus graveolens Boiss. & Reut. using LC‐HRMS, identifying 33 secondary metabolites, with rutin as the major compound (162.808 ± 4.5 μg/g extract). The extract showed moderate antioxidant activity and effectively inhibited acetylcholinesterase (30.88% ± 1.51%) and butyrylcholinesterase (61.22% ± 0.
Ezgi Ersoy, Mehmet Boğa, Alevcan Kaplan, Emel Mataracı Kara, Serpil Demirci Kayıran, Esra Eroğlu Özkan   +5 more
wiley   +1 more source

Influence of Drying Methods on the Phenolic Content and Antioxidant Properties of Crocus sativus L. Tepals and Leaves By‐Products From Meknes (Morocco)

Chemistry &Biodiversity, Volume 22, Issue 7, July 2025.
ABSTRACT In recent years, much research has focused on the valorization of Crocus sativus by‐products as sources of bioactive compounds. This study was designed to investigate the impact of two different drying methods, freeze‐drying and air‐drying, on the phenolic content and antioxidant activity of leaves and tepals by‐products from C.
Soukaina Abou‐Wakil, Francesco Cacciola, Fatima Housti, Mohamed Rochd, Roberto Laganà Vinci, Luigi Mondello, Federica Davì, Nicola Micale, Natalizia Miceli, Maria Fernanda Taviano   +9 more
wiley   +1 more source

The effect of Crocetin on cholesterol depletion-mediated lipid raft disruption-induced apoptosis in breast cancer cells

International Journal of Secondary Metabolite
The purpose of this study was to determine the effect of lipid raft function loss due to depletion of cholesterol in the lipid raft structure of cell membrane by crocetin and Methyl β cyclodextrin (MβCD) on cell viability and lipid raft-associated gene ...
Esma Özmen, Serife Buket Bozkurt Polat
doaj   +1 more source

Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats

Drug Design, Development and Therapy, 2020
Yanshuang Liu,1,2,* Yingran Liang,3,* Bin Zheng,3 Li Chu,3 Donglai Ma,3 Hongfang Wang,3 Xi Chu,4 Jianping Zhang2,5 1Department of Diagnostics, School of Integrated Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei ...
Liu Y, Liang Y, Zheng B, Chu L, Ma D, Wang H, Chu X, Zhang J   +7 more
doaj  

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Pharmaceuticals
Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats induced by various
Renqiang Ma, Sijia Li, Qingmei Mo, Xiaojuan Chen, Yan Liang, Tao Hu, Hui Hu, Bao He, Renshi Li, Junping Kou, Boyang Yu   +10 more
doaj   +1 more source