Results 71 to 80 of about 2,727 (153)

Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats

Drug Design, Development and Therapy, 2020
Yanshuang Liu,1,2,* Yingran Liang,3,* Bin Zheng,3 Li Chu,3 Donglai Ma,3 Hongfang Wang,3 Xi Chu,4 Jianping Zhang2,5 1Department of Diagnostics, School of Integrated Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei ...
Liu Y, Liang Y, Zheng B, Chu L, Ma D, Wang H, Chu X, Zhang J   +7 more
doaj  

Preventive and Therapeutic Effects of Crocetin in Rats with Heart Failure

Pharmaceuticals
Gardenia is both a food and medicine plant. It is widely used for cardiovascular protection, and its main bioactive ingredient is crocetin. This study aims to observe the therapeutic effects of crocetin on chronic heart failure in rats induced by various
Renqiang Ma, Sijia Li, Qingmei Mo, Xiaojuan Chen, Yan Liang, Tao Hu, Hui Hu, Bao He, Renshi Li, Junping Kou, Boyang Yu   +10 more
doaj   +1 more source

Pharmacological Properties of Crocetin and Crocin (Digentiobiosyl Ester of Crocetin) from Saffron

Natural Product Communications, 2006
Functional plant foods and medicinal herbs provide a wide variety of natural products for new drug research and development. Crocetin and crocin (digentiobiosyl ester of crocetin) are the major bioactive ingredients of saffron which is used as a costly ...
Liang Xi, Zhiyu Qian
doaj   +1 more source

Synthesis of crocetin derivatives and their potent inhibition in multiple tumor cells proliferation and inflammatory property of macrophage

BMC Complementary Medicine and Therapies, 2020
Background Crocetin is a major active component of saffron, which has a wide range of pharmacological effects. However, due to its low solubility, the pharmacological effects of crocetin cannot be better utilized.
Mao-Ze Wang, Jin Gao, Yang Chu, Jie Niu, Ming Chen, Qiang Shang, Li-Hua Peng, Zhi-Hong Jiang   +7 more
doaj   +1 more source

Anti-tumor effects of crocetin and related molecular targets

, 2018
Natural products have gained a wide popularity as chemopreventive and anti-cancer agents owing to their multi-mechanistic mode of action, availability and synergism with several conventional chemotherapeutic agents.
Sahebkar, A., Tabarraei, A., Sadeghnia, H.R., Moradzadeh, M.   +3 more
core  

Characterization of Crocetin Isomers in Serum Samples via UHPLC-DAD-MS/MS and NMR after Saffron Extract (Safr’Inside™) Consumption

Metabolites
The therapeutic effects of saffron have been reported and described in relation to its major derivatives. Among them, in terms of saffron’s properties, crocin and crocetin absorption and bioavailability have been the most studied.
Adeline Vignault, Carole Vaysse, Karène Bertand, Stéphanie Krisa, Arnaud Courtois, Benjamin Moras, Tristan Richard, David Gaudout, Line Pourtau   +8 more
doaj   +1 more source

Additional file 1: of Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice

, 2018
Figure S1. Crocetin did not affect cell viability in both APPsw-transfected cells (A) and control Hela cells (B). Cells were treated with crocetin at the indicated concentrations for 24 h. Cell viability was measured using MTT assay.
Jianghua Liu (170107), Jin Zhang (53297), Xueshuang Dong (5913770), Yuchao Wang (1403281)   +3 more
core   +1 more source

An evolutionarily diverged CCD4 enzyme negatively regulates mesocotyl elongation in rice

New Phytologist, Volume 249, Issue 4, Page 1569-1579, February 2026.
Yasha Zhang, Abdugaffor Ablazov, Aparna Balakrishna, Chakravarthy Rajan, Yagiz Alagoz, Kit Xi Liew, Lamis Berqdar, Jian You Wang, Ikram Blilou, Xiongjie Zheng, Salim Al‐Babili   +10 more
wiley   +1 more source

Crocetin protects against cardiac hypertrophy by blocking MEK-ERK1/2 signalling pathway

, 2015
Oxidative stress plays a critical role in the progression of pathological cardiac hypertrophy and heart failure. Because crocetin represses oxidative stress in vitro and in vivo, we have suggested that crocetin would repress cardiac hypertrophy by ...
Shen, Di-Fei, Yi, Fang-Fang, Yang, Long, Yan, Ling, Tang, Qi-Zhu, Cai, Jun, Yang, Xin-Chun, Li, Hongliang, Bian, Zhou-Yan   +8 more
core   +1 more source

Estimation of the Minimum Effective Dose of Dietary Supplement Crocetin for Prevention of Myopia Progression in Mice

, 2020
The natural carotenoid crocetin has been reported to suppress phenotypes of an experimental myopia model in mice. We investigated the minimum effective dose to prevent myopia progression in a murine model. Three-week-old male mice (C57B6/J) were equipped
Kiwako Mori, Toshihide Kurihara, Kazuo Tsubota, Hidemasa Torii, Shin-ichi Ikeda, Erisa Yotsukura, Xiaoyan Jiang   +6 more
core   +1 more source