Results 41 to 50 of about 2,019 (128)

Natural Chiral Scaffolds in Alzheimer′s Disease: Therapeutic Potential, Mechanism, and Clinical Aspects

BioMed Research International, Volume 2026, Issue 1, 2026.
Alzheimer′s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive impairment, amyloid‐β deposition, tau pathology, oxidative stress, neuroinflammation, and dysfunction of synapses. Current therapeutic options are largely symptomatic and lack disease‐modifying efficacy.
Aniket Singh, Sanjeev Kumar Sahu, Anil Kumar Sah, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source

Evaluation of the antidepressant-like effects of acute and sub-acute administration of crocin and crocetin in mice [PDF]

Avicenna Journal of Phytomedicine, 2015
Objective: The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L.
Bahareh Amin, Alireza Nakhsaz, Hossein Hosseinzadeh   +2 more
doaj  

Crocetin Inhibits Lipopolysaccharide-Induced Inflammatory Response in Human Umbilical Vein Endothelial Cells

Cellular Physiology and Biochemistry, 2016
Background/Aim: Crocetin is a readily bioavailable and bioactive compound extracted from Saffron. Previous studies indicated its various biomedical properties including antioxidant and anti-coagulation potencies.
Lei Song, Chen Kang, Yuan Sun, Wenrui Huang, Wei Liu, Zhiyu Qian   +5 more
doaj   +1 more source

From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long, Qianyue Yang, Yonghe Wu, Lifei Wan, Liuting Zeng, Lingyun Sun, Poorani Gurumallesh   +6 more
wiley   +1 more source

Synergistic anticancer effect of combined crocetin and cisplatin on KYSE-150 cells via p53/p21 pathway

Cancer Cell International, 2017
Background More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication.
Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo, Hua-Qiao Wang   +5 more
doaj   +1 more source

Investigation on penetration of saffron components through lipid bilayer bound to spike protein of SARS-CoV-2 using steered molecular dynamics simulation

Heliyon, 2020
A coronavirus identified as COVID-19 is the reason for an infection outbreak which is started in December 2019. NO completely effective drugs and treatments are not recognized for this virus.
Azadeh Kordzadeh, Ahmad Ramazani Saadatabadi, Amin Hadi   +2 more
doaj   +1 more source

Association Between Dietary Patterns and Myopia Among Children and Adolescents: A School‐Based Cross‐Sectional Study

Journal of Ophthalmology, Volume 2026, Issue 1, 2026.
Background The myopia rate has increased rapidly worldwide, yet evidence regarding the association between dietary factors and myopia remains limited. This study assessed the association between dietary patterns and myopia among children and adolescents.
Tongtong Li, Jing Yang, Jing Yan, Xuyang Yao, Bei Du, Qi Wu, Xiangda Meng, Yuanyuan Liu, Yuezhu Lu, Fei Ma, Yun Zhu, Qihua Wang, Qiang Yang, Chea-Su Kee, Cheuk Sing Jason Yam, Allen M. Y. Cheong, Ruihua Wei, Guowei Huang, Hua Yan, Diego García Ayuso   +19 more
wiley   +1 more source

Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I

Cell Death and Disease, 2023
Parthanatos is one of the major pathways of programmed cell death in ischemic stroke characterized by DNA damage, poly (ADP-ribose) polymerases (PARP) activation, and poly (ADP-ribose) (PAR) formation.
Hao Wu, Ying Li, Qian Zhang, Hanxun Wang, Wenyu Xiu, Pu Xu, Yujie Deng, Wanxu Huang, Dan Ohtan Wang   +8 more
doaj   +1 more source

From Floral By‐Product to Bioactive Resource: Phytochemical Profiling and Antioxidant Potential of Crocus sativus Stamens

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study highlights the phytochemical richness and nutritional value of Crocus sativus stamens, characterized through UHPLC–MS/MS and GC–MS analyses. The extracts and fractions showed significant antioxidant potential, supported by multiple in vitro assays.
Samira Mamri, Sanae Baddaoui, Dilaycan Çam, Cansel Çakir, Mohammed Roubi, Raffaele Conte, Yusuf Sıcak, Mehmet Öztürk, Mohammed Choukri, Musaab Dauelbait, Gehan M. Elossaily, Yousef A. Bin Jardan, Abdel‐Rhman Z. Gaafar, Abdeslam Asehraou, Ennouamane Saalaoui   +14 more
wiley   +1 more source

A Comprehensive Review on Key Chemical Constituents of Indian Pulses and Their Multifaceted Health Benefits in a Global Context

Legume Science, Volume 7, Issue 4, December 2025.
ABSTRACT Pulses are edible seeds of legume plants, but they are distinct from legumes because they are dried seeds before consumption. Because of their economic value and high nutritional content, pulses are integral to diets worldwide. Various pulses such as Macrotyloma uniflorum (horse gram), Glycine max (soybeans), Pisum sativum (field peas), Lens ...
Preeti Semwal, Shankar Gupta, Chahat, Gaurav Joshi, Muhammad Wahajuddin, Bhupinder Kumar   +5 more
wiley   +1 more source