Results 41 to 50 of about 2,727 (153)

Saffron aqueous extract effects on paraquat and glyphosate concentration in common carp (Cyprinus carpio) tissues

Agricultural &Environmental Letters, Volume 11, Issue 2, December 2026.
Reduced bioaccumulation of PQ and GLY by saffron extract in Common carp (Cyprinus carpio) tissues Abstract Herbicides such as paraquat (PQ) and glyphosate (GLY) pose ecological and public health risks because of their persistence, bioaccumulation, and toxicity to aquatic organisms. This study evaluated whether aqueous saffron extract (Crocus sativus L.)
Hossein Hammami, Javad Kharkan
wiley   +1 more source

Expression and Interaction Analysis among Saffron ALDHs and Crocetin Dialdehyde

, 2018
In saffron, the cleavage of zeaxanthin by means of CCD2 generates crocetin dialdehyde, which is then converted by an unknown aldehyde dehydrogenase to crocetin. A proteome from saffron stigma was released recently and, based on the expression pattern and
María Garrido-Arandia, Oussama Ahrazem, Luis Pacios, Javier Argandoña, Luis F. Pacios, Ángela Rubio-Moraga, Lourdes Gómez-Gómez, Araceli Diaz-Perales   +7 more
core   +1 more source

Crocetin Prolongs Recovery Period of DSS-Induced Colitis via Altering Intestinal Microbiome and Increasing Intestinal Permeability

, 2022
Crocetin is one of the major active constituents of saffron (Crocus sativus L.) which has a reputation for facilitating blood circulation and dispersing blood stasis in traditional Chinese medicine.
Pan Huang, Siyu Wang, Qiaoqiao Li, Yi Tao, Ling Liu, Peishi Feng, Ping Wang, Zhipeng Wu   +7 more
core   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, Volume 13, Issue 53, 24 September 2026.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Identification of crocin, crocetin and zeaxanthin in Crocus sativus grown under controlled environment in Malaysia [PDF]

, 2018
Purpose: The purpose of the study is to identify the high valuable compounds which are crocin, crocetin and zeaxanthin in the stigmas and stamens of Crocus sativus grown under controlled environment in Malaysia.
Othman, Rashidi, Anuar, Nordiyanah, Taha, Rosna Mat, Mahmad, Noraini   +3 more
core   +3 more sources

Crocetin suppresses the growth and migration in HCT-116 human colorectal cancer cells by activating the p-38 MAPK signaling pathway

Research in Pharmaceutical Sciences, 2020
Background and purpose: Crocetin is a natural antioxidant that is found in the crocus flower and Gardenia jasminoides (fruit). Previous studies have reported its anticancer activity both in vivo and in vitro.
Esmaeil Khajeh, Yousef Rasmi, Fatemeh Kheradmand, Hassan Malekinejad, Pornanong Aramwit, Ehsan Saboory, Behrokh Daeihassani, Mahdieh Nasirzadeh   +7 more
doaj   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism‐Based Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Phenolic antioxidants in CHMs mainly include chalcone, stilbene, flavonoid, xanthone, and Diels–Alder‐type adducts. They undergo direct and indirect pathways to exert antioxidant action. The indirect pathway is transition metal‐chelating, while the direct pathway comprises several redox‐based reactions (e.g., SET and HAT) and RAF reactions.
Xican Li
wiley   +1 more source

Monoolein liquid crystalline phases for topical delivery of crocetin

, 2018
The present investigation concerns the production and characterization of monoolein-water systems designed for cutaneous administration of crocetin. The different monoolein crystalline phases forming in the presence of crocetin as a function of added ...
Mariani, Paolo, Cortesi, Rita, Esposito, Elisabetta, G. Romeo, E. Esposito, Simelière, Fanny, F. Carducci, F. Simelière, P. Mariani, N. Huang, Huang, Nicolas, Carducci, Federica, R. Cortesi, Romeo, Giuseppe, Puglia, Carmelo, C. Puglia   +15 more
core   +2 more sources

Crocetin Protected Human Hepatocyte LO2 Cell From TGF-β-Induced Oxygen Stress and Apoptosis but Promoted Proliferation and Autophagy via AMPK/m-TOR Pathway

Frontiers in Public Health, 2022
ObjectiveTo investigate the protective effects of crocetin against transforming growth factor-β (TGF-β)—induced injury in LO2 cells.MethodsHuman hepatocyte LO2 cells were pre-treated with crocetin (10 μM) for 6, 12, and 24 h, and then induced by TGF-β ...
Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao   +5 more
doaj   +1 more source