Results 21 to 30 of about 2,019 (128)
Parkinson's Disease, 2020 Parkinson’s disease (PD) is the second most common neurodegenerative disease. Crocetin, derived from saffron, exerts multiple pharmacological properties, such as anti-inflammatory, antioxidant, antifatigue, and anticancer effects.
Na Dong +3 more
doaj +1 more source
Heterologous biosynthesis and manipulation of crocetin in Saccharomyces cerevisiae
Microbial Cell Factories, 2017 Background Due to excellent performance in antitumor, antioxidation, antihypertension, antiatherosclerotic and antidepressant activities, crocetin, naturally exists in Crocus sativus L., has great potential applications in medical and food fields ...
Fenghua Chai +7 more
doaj +1 more source
Integrative Analyses of Metabolome and Transcriptome Reveals Apocarotenoid and Flavonoid Biosynthesis During Saffron (<i>Crocus sativus</i> L.) Stigmas Development. [PDF]
Food Sci NutrDuring the development of saffron stigmas, crocetin and flavonoids were primarily synthesized in the early red stage (S1), while crocins were synthesized in the late red stage (S2). The biosynthesis pathways of ABA and picrocrocin were particularly active at anthesis (S3).
Chen J +8 more
europepmc +2 more sources
Crocetin Activates Foxp3 Through TIPE2 in Asthma-Associated Treg Cells
Cellular Physiology and Biochemistry, 2015 Background/Aims: Regulatory T cells (Treg) are critical regulators of asthma. Crocetin is isolated from Chinese herb saffron and is a natural carotenoid dicarboxylic acid with anti-inflammatory potential.
Jurong Ding +3 more
doaj +1 more source
Iodine-induced synthetic method and pharmacokinetic study of cis- and trans-crocetin
Frontiers in PharmacologyObjective:This experiment aimed to obtain the relatively rare cis-crocetin isomer from natural plants, which predominantly exist in the more stable all-trans configuration.
Boshen Li +18 more
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Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice
Clinics, 2013 OBJECTIVE: To investigate the antifibrotic effects of crocetin in scleroderma fibroblasts and in sclerotic mice. METHODS: Skin fibroblasts that were isolated from three systemic scleroderma (SSc) patients and three healthy subjects were treated with ...
Yinghua Song, Lubing Zhu, Ming Li
doaj +1 more source
Crocetin attenuates spared nerve injury-induced neuropathic pain in mice
Journal of Pharmacological Sciences, 2017 Crocetin is the main component of saffron and exhibits anti-oxidative and anti-inflammatory effects. Neuroinflammation and oxidative stress have been recognized to play a crucial role in the pathogenesis of neuropathic pain. We investigated the effect of
Xiaolei Wang +4 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 5, May 2026.This study mainly consists of two parts. First, after screening for drug‐like metabolites via LC–MS and GC–MS, a comprehensive evaluation model was established using a principal component analysis‐based weighted scoring method, by which the drug‐likeness ranking of three samples was determined.
Han Chen +6 more
wiley +1 more source
Research in Pharmaceutical Sciences, 2020 Background and purpose: Crocetin is a natural antioxidant that is found in the crocus flower and Gardenia jasminoides (fruit). Previous studies have reported its anticancer activity both in vivo and in vitro.
Esmaeil Khajeh +7 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 4, April 2026.Graphical representation of the metabolic pathways modulated by saffron within defined microbial communities. In the tryptophan pathway, saffron decreased levels of tryptophan and anthranilic acid while increasing concentrations of indole‐3‐acetic acid and tryptamine.
Adelaide E. Horvath +9 more
wiley +1 more source