Results 11 to 20 of about 2,019 (128)

Bioconversion of carotenoids into high-value crocins using a marine sponge carotenoid cleavage dioxygenase. [PDF]

New Phytol
Summary Carotenoids and apocarotenoids are widespread specialized metabolites, yet animals, including sponges, lack the ability to synthesize carotenoids de novo and must obtain them from dietary or microbial sources. The roles of carotenoid cleavage dioxygenases (CCDs) in marine animals remain largely unexplored. A CCD from the marine sponge Suberites
Moreno-Giménez E, Morote L, Jiménez AJL, Parreño E, Wang JY, Nava M, Aguado C, Luján R, Al-Babili S, Diretto G, Ahrazem O, Gómez-Gómez L.   +11 more
europepmc   +2 more sources

A comparative molecular docking study of crocetin with multiple receptors for the treatment of alzheimer's disease

Biomedical and Biotechnology Research Journal, 2022
Background: Crocetin, an active constituent derived from Crocus sativus L. and Gardenia jasminoides, has shown to have multiple pharmacological activities such as memory booster, anti-oxidants, anti-inflammatory, and neuroprotective actions.
Dhanashree Sharadchandra Kherade, Vrushali Sachin Tambe, Anupa Dnyaneshwar Wagh, Prajakta Bhushan Kothawade   +3 more
doaj   +1 more source

Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways

Frontiers in Pharmacology, 2021
Crocetin and crocin are two important carotenoids isolated from saffron (Crocus sativus L.), which have been used as natural biomedicines with beneficial effects for improving the suboptimal health status associated with abnormal angiogenesis.
Chen Zhao, Hio-Tong Kam, Yan Chen, Guiyi Gong, Maggie Pui-Man Hoi, Krystyna Skalicka-Woźniak, Alberto Carlos Pires Dias, Simon Ming-Yuen Lee   +7 more
doaj   +1 more source

Crocetin Improves Dengue Virus-Induced Liver Injury

Viruses, 2020
Dengue virus (DENV) infection is one of the most widespread mosquito-borne viral infections. Liver injury is commonly observed in severe DENV infection, and the present study aimed to examine the efficacy of crocetin treatment in an immunocompetent mouse
Gopinathan Pillai Sreekanth, Aporn Chuncharunee, Pa-thai Yenchitsomanus, Thawornchai Limjindaporn   +3 more
doaj   +1 more source

The effects of crocetin, extracted from saffron, in chemotherapy against the incidence of multiple drug resistance phenotype [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Crocetin, one of the main substances of saffron extract, has anti-cancer effects. Drug resistance proteins (e.g. MRP1 and MRP2) are important reasons for the failure of cancer therapy.
Navid Neyshaburinezhad, Maryam Hashemi, Mohammad Ramezani, Sepideh Arabzadeh, Javad Behravan, Fatemeh Kalalinia   +5 more
doaj   +1 more source

The effect of eight weeks of interval aerobic training with the consumption of crocetin extract on some indices of angiogenesis of the heart tissue of prediabetic and diabetic aged rats [PDF]

Armaghane Danesh Bimonthly Journal, 2023
Background and aims: Diabetes is associated with cardiovascular and metabolic disorders. Although the favorable role of physical activity and antioxidants in people's health has been reported, the simultaneous effect of HIIT and crocetin on angiogenesis ...
Shahram Pouya, khosro jalali dehkordi, Farzaneh Taghian, Mehdi Kargarfard, seyed Ali Hoseini   +4 more
doaj  

Functional, Nutraceutical and Health Endorsing Perspectives of Saffron. [PDF]

Food Sci Nutr
Saffron is generally regarded as safe for human consumption in moderate quantities, its potential adverse effects at higher doses require careful consideration. This review presents a balanced perspective on saffron's medicinal potential and its safe usage, making it a valuable resource for researchers and healthcare professionals.
Tufail T, Ain HBU, Ikram A, Arshad MT, Abdullahi MA.   +4 more
europepmc   +2 more sources

Preparation and evaluation of wound healing activity of phytosomes of crocetin from Nyctanthes arbor-tristis in rats

Journal of Traditional and Complementary Medicine, 2022
Background and aim: Orange colored tubular calyx of the flowers of Nyctanthes arbor-tristis contains an apocarotenoid crocin as a major ingredient, which is originally detected to be major colouring principle of saffron stigma.
Manasi Varadkar, Chhaya Gadgoli
doaj   +1 more source

Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells

Journal of Pharmacological Sciences, 2022
The corneal epithelium is located at the outermost layer of the ocular surface and continuously exposed to environmental factors, such as ultraviolet (UV) radiation from sunlight. UV irradiation causes excessive production of reactive oxygen species (ROS)
Wataru Otsu, Tomohiro Yako, Emi Sugisawa, Shinsuke Nakamura, Hideshi Tsusaki, Naofumi Umigai, Masamitsu Shimazawa, Hideaki Hara   +7 more
doaj   +1 more source

Parabens as Agents for Improving Crocetin Esters’ Shelf-Life in Aqueous Saffron Extracts

Molecules, 2009
The effect of parabens on the shelf-life of crocetin esters and picrocrocin in aqueous saffron solutions was studied. Degradation of saffron crocetin esters fits a first-order kinetics model, and the results indicated that the crocetin (β-D-glucosyl)-(β ...
Magdalena Martínez Tomé, Gonzalo Luis Alonso, María Antonia Murcia, Amaya Zalacain, Manuel Carmona, Luana Maggi   +5 more
doaj   +1 more source