Results 31 to 40 of about 2,019 (128)

LKB1–AMPK Signaling Pathway in Cardiovascular and Other Diseases

MedComm, Volume 7, Issue 3, March 2026.
The LKB1–AMPK pathway has a central regulatory role in various diseases. Dysfunction of this pathway can lead to pathological processes in cardiovascular diseases (atrial fibrillation, myocardial infarction, myocardial hypertrophy, atherosclerosis), metabolic diseases (diabetes and kidney disease), neurodegenerative diseases (Alzheimer's disease ...
Zhuo Chen, Qin Yang, Guo‐Wei He
wiley   +1 more source

Beta-adrenergic receptor stimulation, histamine receptor inhibition, and potassium channel opening contribute to the relaxant effects of crocetin on airway smooth muscle [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): In the present study, the relaxant effect of crocetin on tracheal smooth muscle cells (TSM) and its possible mechanisms were evaluated.Materials and Methods: The study was conducted on 54 male Wistar rats in 8 groups.
Sepide Behrouz, Arghavan Memarzia, Mohammad Hossein Eshaghi Ghalibaf, Mohammad Hossein Boskabady   +3 more
doaj   +1 more source

Combined Analysis of Transcriptome and Metabolome Explains the Differences in Pulp Color in Jackfruit

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT The pulp color of jackfruit reflects variations in its nutritional composition and influences market preference. We investigated the mechanism underlying pulp coloration through an integrated transcriptomic and metabolomic analysis of three jackfruit cultivars—light yellow “THA”, yellow “GTM”, and orange “YNH”.
Jianjun Liang, Xiangwei Ma, Chenxin Yi, Hailan Zhou, Zhuangmin Wei, Xiuguan Tang, Weiyan Ye, Hailing Tang, Pengjin Zhu   +8 more
wiley   +1 more source

Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy

Tumor Biology, 2017
The chemotherapy with fluorouracil is not always effective, in which some breast cancer cells may survive the fluorouracil treatment through enhanced autophagy.
Ailian Zhang, Jincheng Li
doaj   +1 more source

Oral Administration of Crocus sativus Tepals Extract Restores High‐Fat Diet‐Induced Gut Dysbiosis and Modulates Intestinal Inflammation and Hepatic Lipid Metabolism

BioFactors, Volume 52, Issue 1, January/February 2026.
This study shows that oral administration of Crocus sativus tepals extract (CTE) restores gut microbiota composition and promotes SCFA‐producing and anti‐inflammatory bacterial genera. It improves intestinal barrier integrity and reduces inflammation in the jejunum and liver, suggesting a possible link between the gut microbiota and the metabolic ...
Biljana Bursać, Miloš Vratarić, Ljupka Gligorovska, Luisa Bellachioma, Ana Teofilović, Danijela Vojnović Milutinović, Camilla Morresi, Elisabetta Damiani, Tiziana Bacchetti, Ana Djordjevic   +9 more
wiley   +1 more source

Gene Expression Profiling and Biofunction Analysis of HepG2 Cells Targeted by Crocetin

Mediators of Inflammation, 2021
Crocetin is a carotenoid extracted from Gardenia jasminoides, one of the most popular traditional Chinese medicines, which has been used in the prevention and treatment of various diseases.
Yi-Ling Wen, Yong Li, Guangcheng Zhu, Zhibing Zheng, Meng Shi, Si Qin   +5 more
doaj   +1 more source

Development of Efficient Supramolecular Photostabilizer for Carotenoids and Retinoids: Analyses and Application Research

Journal of Cosmetic Dermatology, Volume 25, Issue 1, January 2026.
ABSTRACT Background Carotenoids and retinol are well known for their potent antioxidant and biological properties in pharmaceuticals, foods, and cosmetics. However, their poor photostability presents a significant challenge that cannot be effectively addressed through simple formulation strategies such as encapsulation.
Mengqing Zhao, Shuang Chen, Ke Hu, V. I. Evseenko, E. S. Meteleva, M. V. Zelikman, A. V. Dushkin, A. V. Mastova, M. A. Ulyanova, P. A. Kononova, O. Yu. Selyutina, Wenhao Xu, N. E. Polyakov   +12 more
wiley   +1 more source

Construction of Escherichia coli cell factories for crocin biosynthesis

Microbial Cell Factories, 2019
Background Crocin is a carotenoid-derived natural product found in the stigma of Crocus spp., which has great potential in medicine, food and cosmetics.
Wen Wang, Ping He, Dongdong Zhao, Lijun Ye, Longhai Dai, Xueli Zhang, Yuanxia Sun, Jing Zheng, Changhao Bi   +8 more
doaj   +1 more source

Crocetin Protected Human Hepatocyte LO2 Cell From TGF-β-Induced Oxygen Stress and Apoptosis but Promoted Proliferation and Autophagy via AMPK/m-TOR Pathway

Frontiers in Public Health, 2022
ObjectiveTo investigate the protective effects of crocetin against transforming growth factor-β (TGF-β)—induced injury in LO2 cells.MethodsHuman hepatocyte LO2 cells were pre-treated with crocetin (10 μM) for 6, 12, and 24 h, and then induced by TGF-β ...
Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao   +5 more
doaj   +1 more source

The Antioxidant Activity of a Prepared Cream Containing Saffron Extract and Grape Seed Extract

BioMed Research International, Volume 2026, Issue 1, 2026.
This study evaluates the antioxidant activity of a topical water‐in‐oil cream formulated with saffron (Crocus sativus) and grape seed (Vitis vinifera) extracts and characterizes its physicochemical properties. HPLC profiling confirmed that grape seed extract was rich in catechins (26.7%), epicatechins (21.9%), and procyanidins B1 and B2 (13.6% and 9.5%)
Wissam Zam, Aziz Alkhaddour, Samer Housheh, Poorani Gurumallesh Prabu   +3 more
wiley   +1 more source