Results 1 to 10 of about 2,000 (112)

Crocetin Overproduction in Engineered Saccharomyces cerevisiae via Tuning Key Enzymes Coupled With Precursor Engineering

Frontiers in Bioengineering and Biotechnology, 2020
Crocetin, an important natural carotenoid dicarboxylic acid with high pharmaceutical values, has been successfully generated from glucose by engineered Saccharomyces cerevisiae in our previous study.
Tian-Qing Song, Chen Wang, Ying Wang
exaly   +3 more sources

Crocetin: A Systematic Review

Frontiers in Pharmacology, 2022
Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological systems by hydrolysis of crocin as a bioactive metabolite.
Zi-Liang Guo, Zi-Liang Guo, Mao-Xing Li, Mao-Xing Li, Mao-Xing Li, Xiao-Lin Li, Peng Wang, Peng Wang, Wei-Gang Wang, Wei-Gang Wang, Wei-Ze Du, Wei-Ze Du, Zhi-Qiang Yang, Zhi-Qiang Yang, Sheng-Fu Chen, Sheng-Fu Chen, Di Wu, Di Wu, Xiu-Yu Tian, Xiu-Yu Tian   +19 more
exaly   +3 more sources

Biotechnological production of crocetin and crocins using a carotenoid cleavage dioxygenase (CCD4) from Nyctanthes arbor-tristis [PDF]

Frontiers in Plant Science
Crocins are hydrophilic crocetin esters composed of a linear chain with glucose molecules added at the end. Crocins and crocetin are used as cosmetic agents and effective pharmaceuticals for the treatment of several diseases.
Lucía Morote, Elena Moreno Giménez, Alberto José López Jiménez, Alberto José López Jiménez, Ángela Rubio-Moraga, Ángela Rubio-Moraga, Verónica Aragonés, Oussama Ahrazem, Oussama Ahrazem, José-Antonio Daròs, Lourdes Gómez-Gómez, Lourdes Gómez-Gómez   +11 more
doaj   +2 more sources

Crocetin curbs radiation induced intestinal injury by blocking KAT2A/NLRP3 succinylation [PDF]

Scientific Reports
Irradiation (IR) is known to damage the intestinal mucosal barrier, leading to serious intestinal injury. Crocetin is a natural active compound derived from the enzymatic deglycosylation of crocin in the intestines.
He Chen, Yanping Wang, Yi Xu, Fu Liu, Quanxiao Xu, Lei Dong, Changxiang Yang, Xu Xie, Jincong Yang, Xinping Zhang   +9 more
doaj   +2 more sources

Novel insights into the protective role of crocetin from gardenia jasminoides against mitochondrial hypoxia [PDF]

Scientific Reports
This study aimed to optimize the preparation process of crocetin from gardenia fruit via alkaline hydrolysis using Box-Behnken response surface design, and to investigate its antioxidant activity and protective effect against mitochondrial hypoxic damage.
Li Boshen, Zhang Mingxia, Wang Renjie, Luo Kai, Qian Qingyuan, Li Xiaolin, Li Maoxing   +6 more
doaj   +2 more sources

Effects of Crocetin Esters and Crocetin from Crocus sativus L. on Aortic Contractility in Rat Genetic Hypertension

Molecules, 2015
Background: Endothelial dysfunction, characterized by an enhancement in vasoconstriction, is clearly associated with hypertension. Saffron (Crocus sativus L.) bioactive compounds have been recognized to have hypotensive properties.
Silvia Llorens, Anna M D'Alessandro, Eduardo Nava   +2 more
exaly   +3 more sources

Metabolic engineering of Yarrowia lipolytica for the production and secretion of the saffron ingredient crocetin [PDF]

Biotechnology for Biofuels and Bioproducts
Background Crocetin is a multifunctional apocarotenoid natural product derived from saffron, holding significant promises for protection against various diseases and other nutritional applications.
Tingan Zhou, Young-Kyoung Park, Jing Fu, Piotr Hapeta, Cinzia Klemm, Rodrigo Ledesma-Amaro   +5 more
doaj   +2 more sources

Processing-induced changes in neuroprotective components and mechanisms of gardeniae fructus: integrating UPLC-Q-TOF-MS/MS, network pharmacology, and in vitro analysis [PDF]

Bioresources and Bioprocessing
Objective Gardeniae Fructus (GF), the dried fruit of Gardenia jasminoides J. Ellis, has been used in East Asian medicine for centuries. Its carbonized form, Gardeniae Fructus Carbonisatus (GFC), is produced through processing, yet the effects of this ...
Le Sun, Ziyu Hou, Wenjie Wang, Peiling Wu, Pei Ma, Jiali Huang, Leyang Fan , Lijia Xu, Haibo Liu, Peigen Xiao   +9 more
doaj   +2 more sources

Changes of Crocin and Other Crocetin Glycosides in Saffron Through Cooking Models, and Discovery of Rare Crocetin Glycosides in the Yellow Flowers of Freesia Hybrida

Frontiers in Nutrition, 2022
Crocetin glycosides such as crocin are noted as functional food materials since the preventive effects of crocin have been reported against chronic disease and cancer.
Kazutoshi Shindo, Kazutoshi Shindo, Yuka Sakemi, Saki Shimode, Chiharu Takagi, Yohei Uwagaki, Jun-ichiro Hattan, Miu Akao, Shiori Usui, Ayako Kiyokawa, Masako Komaki, Minoru Murahama, Miho Takemura, Isamu Ishikawa, Norihiko Misawa, Norihiko Misawa   +15 more
doaj   +1 more source

Construction of a Stable and Temperature-Responsive Yeast Cell Factory for Crocetin Biosynthesis Using CRISPR-Cas9

Frontiers in Bioengineering and Biotechnology, 2020
Crocetin is a plant natural product with broad medicinal applications, such as improvement of sleep quality and attenuation of physical fatigue. However, crocetin production using microbial cell factories is still far from satisfaction, probably due to ...
Tengfei Liu, Tengfei Liu, Chang Dong, Chang Dong, Mingming Qi, Mingming Qi, Bei Zhang, Lei Huang, Zhinan Xu, Jiazhang Lian, Jiazhang Lian   +10 more
doaj   +1 more source