Results 1 to 10 of about 2,727 (153)

Effects of Crocetin Esters and Crocetin from Crocus sativus L. on Aortic Contractility in Rat Genetic Hypertension [PDF]

Molecules, 2015
Background: Endothelial dysfunction, characterized by an enhancement in vasoconstriction, is clearly associated with hypertension. Saffron (Crocus sativus L.) bioactive compounds have been recognized to have hypotensive properties.
Silvia Llorens, Anna Maria D'Alessandro, Gonzalo L Alonso   +2 more
exaly   +4 more sources

Biotechnological production of crocetin and crocins using a carotenoid cleavage dioxygenase (CCD4) from Nyctanthes arbor-tristis [PDF]

Frontiers in Plant Science
Crocins are hydrophilic crocetin esters composed of a linear chain with glucose molecules added at the end. Crocins and crocetin are used as cosmetic agents and effective pharmaceuticals for the treatment of several diseases.
Lucía Morote, Elena Moreno Giménez, Alberto José López Jiménez, Alberto José López Jiménez, Ángela Rubio-Moraga, Ángela Rubio-Moraga, Verónica Aragonés, Oussama Ahrazem, Oussama Ahrazem, José-Antonio Daròs, Lourdes Gómez-Gómez, Lourdes Gómez-Gómez   +11 more
doaj   +4 more sources

Crocetin: A Systematic Review

Frontiers in Pharmacology, 2022
Crocetin is an aglycone of crocin naturally occurring in saffron and produced in biological systems by hydrolysis of crocin as a bioactive metabolite.
Mao-Xing Li
exaly   +3 more sources

The assembly of tetrameric human L-lactate dehydrogenase is regulated by ionic strength, β-NADH binding, cyclic peptides, and long-chain dicarboxylates. [PDF]

Protein Sci
Abstract Lactate dehydrogenases catalyze the reduction of pyruvate to lactate, the generation of which is of importance for the energetic metabolism of malignant cells. In particular, human cancer cells overexpress lactate dehydrogenase A (hLDH‐A), whose catalytic activity depends on its assembly into the corresponding homotetramer (denoted as hLDH‐5),
Stefan A, Gentilucci L, Barbiroli AG, Rossi V, Liao H, Di Stefano G, He T, Hochkoeppler A.   +7 more
europepmc   +2 more sources

The Therapeutic Effects of <i>Crocus sativus L</i>. and Its Constituents on the Improving Treatment of Azoospermia: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Azoospermia, defined as the complete absence of sperm in the ejaculate, is a major cause of male infertility and is classified into obstructive and non‐obstructive forms. While obstructive azoospermia is primarily mechanical in origin, non‐obstructive azoospermia (NOA) is characterized by impaired spermatogenesis and is ...
Khakshour F, Tehran MH, Shahri JJ, Zeynali F, Arab FL.   +4 more
europepmc   +2 more sources

<i>Crocus sativus</i> (Saffron) Aqueous Extract Mediated Green Synthesis of Iron Oxide Nanoparticles and Their In Vitro and In Vivo Biological Investigations. [PDF]

Food Sci Nutr
The Crocus sativus (saffron) aqueous extract mediated green synthesis of iron oxide nanoparticles and their in vitro and in vivo biological investigations. ABSTRACT The present study reports the green synthesis of iron oxide nanoparticles (IONPs) using the aqueous extract of Crocus sativus (saffron) as a natural reducing and stabilizing agent, followed
Rauf A, Shehzad K, Naeem H, Usama S, Ahmad Z, Khan B, Muhammad N, Shafique M, Al-Awthan YS, Bahattab OS, Quradha MM.   +10 more
europepmc   +2 more sources

Dietary Terpenoids in Advancing Biofilm-Mediated Cancer Prevention: Antibiofilm Cascade, Molecular Crosstalk, and Nano-Facilitated Functional Delivery. [PDF]

Cell Biochem Funct
ABSTRACT The role of microbes in cancer is gaining attention these days, especially in the context of tumor‐associated biofilms and dysbiotic microbiota. Biofilm‐producing microorganisms, such as Fusobacterium nucleatum and Helicobacter pylori, trigger oncogenic inflammation and immune evasion in tumor initiation and progression, and in the development
Mazumder S, Dey A, Bhattacharya D, Lahiri D, Nag M, Maity S, Kumar N, Pandit S, Raja V, Sharma S, Dwivedi SP, Rajeev M, Dewi JR, Sanayeva L, Azimova D.   +14 more
europepmc   +2 more sources

Novel insights into the protective role of crocetin from gardenia jasminoides against mitochondrial hypoxia [PDF]

Scientific Reports
This study aimed to optimize the preparation process of crocetin from gardenia fruit via alkaline hydrolysis using Box-Behnken response surface design, and to investigate its antioxidant activity and protective effect against mitochondrial hypoxic damage.
Li Boshen, Zhang Mingxia, Wang Renjie, Luo Kai, Qian Qingyuan, Li Xiaolin, Li Maoxing   +6 more
doaj   +2 more sources

Bioconversion of carotenoids into high-value crocins using a marine sponge carotenoid cleavage dioxygenase. [PDF]

New Phytol
Summary Carotenoids and apocarotenoids are widespread specialized metabolites, yet animals, including sponges, lack the ability to synthesize carotenoids de novo and must obtain them from dietary or microbial sources. The roles of carotenoid cleavage dioxygenases (CCDs) in marine animals remain largely unexplored. A CCD from the marine sponge Suberites
Moreno-Giménez E, Morote L, Jiménez AJL, Parreño E, Wang JY, Nava M, Aguado C, Luján R, Al-Babili S, Diretto G, Ahrazem O, Gómez-Gómez L.   +11 more
europepmc   +2 more sources

Crocetin curbs radiation induced intestinal injury by blocking KAT2A/NLRP3 succinylation [PDF]

Scientific Reports
Irradiation (IR) is known to damage the intestinal mucosal barrier, leading to serious intestinal injury. Crocetin is a natural active compound derived from the enzymatic deglycosylation of crocin in the intestines.
He Chen, Yanping Wang, Yi Xu, Fu Liu, Quanxiao Xu, Lei Dong, Changxiang Yang, Xu Xie, Jincong Yang, Xinping Zhang   +9 more
doaj   +2 more sources