Results 51 to 60 of about 494,021 (266)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat

Frontiers in Plant Science
Diversification of the hexaploid (bread) wheat genetic pool using wild genetic resources relies on effective meiotic recombination (crossover) between wheat chromosomes and their counterparts from related species (homoeologues).
Camille Haquet, Isabelle Nadaud, Azahara C. Martin, Azahara C. Martin, Maria-Dolores Rey, Maria-Dolores Rey, Asma Ben Bouslah, Carus John-Bejai, Graham Moore, Pierre Sourdille   +9 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dynamic transcriptomic features accompanying the onset of first flowering in roses

BMC Plant Biology
Background Onset time of the first flowering is pivotal for the reproductive success of perennial polycarpic plants especially in woody species, like roses.
Jing Wen, Jiu-Xia Zhao, Mi-Cai Zhong, Wei-Hua Cui, Shi-Zhao Zhou, Dan Wang, Shu Wang, Chun-Tao Wang, Xiao-Dong Jiang, Jin-Yong Hu   +9 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Indigenous crop diversity maintained despite the introduction of major global crops in an African centre of agrobiodiversity

Plants, People, Planet, 2023
Societal Impact Statement The global success and expansion of a small pool of major crops, including rice, wheat and maize, risks homogenising global agriculture.
Chris Rampersad, Tesfu Geto, Tarekegn Samuel, Meseret Abebe, Marybel Soto Gomez, Samuel Pironon, Lucie Büchi, Jeremy Haggar, Jonathan Stocks, Philippa Ryan, Richard J. A. Buggs, Sebsebe Demissew, Paul Wilkin, Wendawek M. Abebe, James S. Borrell   +14 more
doaj   +1 more source

Seed systems and crop genetic diversity in agroecosystems [PDF]

, 2015
Poster presented at the First Diversitas Open Science Conference.
Brown, A.H.D., Colledo, L., Didier, B., Hodgkin, T., Jarvis, D., Karamura, R., Latournerie, L., Mar, I., Rana, R., Sadiki, M., Sawadogo, M., Subedi, A., Tuxill, J., Valdivia, R.O.   +13 more
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LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Coccinellidae on native and introduced spruce in central Europe: conservation implications in urban areas

Frontiers in Ecology and Evolution
The abundance and species composition of adult ladybird communities (Coleoptera: Coccinellidae) were investigated on two congeneric trees, native Norway spruce (Picea abies) and the introduced blue spruce (Picea pungens), at four locations in Slovakia ...
Terézia Jauschová, Terézia Jauschová, Lenka Sarvašová, Peter Zach, Miroslav Saniga, Zdenka Martinková, Alois Honěk, Jiří Skuhrovec, Milada Holecová, Ján Kulfan   +9 more
doaj   +1 more source

Increasing Cultivar Diversity of Processing Tomato under Large Scale Organic Production in California [PDF]

, 2008
At an organic farm in California, higher plant diversity was hypothesized to enhance ecosystem functions and services. Plant diversity was manipulated temporally and spatially: mustard cover crop vs.
Barrios Masias, Felipe, Jackson, Louise
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