Results 1 to 10 of about 505,675 (294)
The purinergic receptor P2X7 as a modulator of viral vector-mediated antigen cross-presentation [PDF]
Frontiers in ImmunologyIntroductionModified Vaccinia Virus Ankara (MVA) is a safe vaccine vector inducing long- lasting and potent immune responses. MVA-mediated CD8+T cell responses are optimally induced, if both, direct- and cross-presentation of viral or recombinant ...
Ylenia Longo +13 more
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Dendritic cell-based vaccine prepared with recombinant Lactococcus lactis enhances antigen cross-presentation and antitumor efficacy through ROS production [PDF]
Frontiers in Immunology, 2023 IntroductionLactococcus lactis (L.L) is safe and can be used as vehicle. In this study, the immunoregulatory effect of L.L on dendritic cell (DC) activation and mechanism were investigated. The immune responses and antigen cross-presentation mechanism of
Tingting Zhang +7 more
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STxB as an Antigen Delivery Tool for Mucosal Vaccination
Toxins, 2022 Immunotherapy against cancer and infectious disease holds the promise of high efficacy with minor side effects. Mucosal vaccines to protect against tumors or infections disease agents that affect the upper airways or the lung are still lacking, however ...
Eric Tartour, Ludger Johannes
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Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes
eLife, 2023 The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes.
Eli Olson +2 more
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Frontiers in Cell and Developmental Biology, 2023 Major histocompatibility complex (MHC) class I and II are crucial for the adaptive immune system because they are involved in peptide presentation to T cells.
Synne Arstad Bjørnestad +5 more
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Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines
Frontiers in Immunology, 2021 Peptide-based cancer vaccines rely upon the strong activation of the adaptive immune response to elicit its effector function. They have shown to be highly specific and safe, but have yet to prove themselves as an efficacious treatment for cancer in the ...
Alexander J. Stephens +3 more
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Frontiers in Immunology, 2023 IntroductionIn immunocompromised patients, Epstein-Barr virus (EBV) infection or reactivation is associated with increased morbidity and mortality, including the development of B-cell lymphomas.
Sabine Tischer-Zimmermann +11 more
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Recent Advances in Nanotechnology for Dendritic Cell-Based Immunotherapy
Frontiers in Pharmacology, 2020 Dendritic cells (DCs) are the most important antigen-presenting cells that determine cancer immune responses by regulating immune activation and tolerance, especially in the initiation stage of specific responses.
Chen Qian, Li-Jun Yang, Hong Cui
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Frontiers in Bioengineering and Biotechnology, 2021 Heat shock proteins 90 kDa (Hsp90s) were originally identified as stress-responsive proteins and described to participate in several homeostatic processes.
Mariana G. Corigliano +6 more
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Frontiers in Immunology, 2021 During cross-presentation, exogenous antigens (i.e. intracellular pathogens or tumor cells) are internalized and processed within the endocytic system and also by the proteasome in the cytosol.
Diego Del Balzo +3 more
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