Results 11 to 20 of about 505,675 (294)
The evolving biology of cross-presentation. [PDF]
Semin Immunol, 2023 Cross-priming was first recognized in the context of in vivo cytotoxic T lymphocyte (CTL) responses generated against minor histocompatibility antigens induced by immunization with lymphoid cells. Even though the basis for T cell antigen recognition was still largely unclear at that time, these early studies recognized the implication that such minor ...
Ohara RA, Murphy KM.
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Antigen Cross-Presentation by Macrophages [PDF]
Frontiers in Immunology, 2020 The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has been recognized widely. Although originally thought to be an exclusive characteristic of DCs, recently also other immune cells, particularly macrophages, have been shown ...
Elke M. Muntjewerff +3 more
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A new route to cross-presentation [PDF]
Nature Reviews Immunology, 2005 Elaine Bell
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Intracellular events regulating cross-presentation [PDF]
Frontiers in Immunology, 2012 Cross-presentation plays a fundamental role in the induction of CD8-T cell immunity. However, although more than three decades have passed since its discovery, surprisingly little is known about the exact mechanisms involved. Here we give an overview of the components involved at different stages of this process.
Wagner, Claudia S. +2 more
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Antigen Cross-Presentation of Immune Complexes [PDF]
Frontiers in Immunology, 2014 The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway for therapeutic purposes is a better understanding of the mechanisms that underlie the induction ...
Platzer, Barbara +2 more
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The many roads to cross-presentation [PDF]
The Journal of Experimental Medicine, 2005 Cross-presentation of extracellular antigens by MHC class I molecules is required for priming cytotoxic T lymphocytes (CTLs) at locations remote from the site of infection. Various mechanisms have been proposed to explain cross-presentation. One such mechanism involves the fusion of the endoplasmic reticulum (ER) with the endosomal-phagosomal system ...
Groothuis, Tom A.M., Neefjes, Jacques
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Frontiers in Immunology, 2022 Conventional vaccines are very efficient in the prevention of bacterial infections caused by extracellular pathogens due to effective stimulation of pathogen-specific antibodies.
Ying Waeckerle-Men +13 more
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Intracellular transport routes for MHC class I and their relevance for antigen cross-presentation
Frontiers in Immunology, 2015 Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance.
Cézaire Aimé Adiko +4 more
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The Macroautophagy Machinery in MHC Restricted Antigen Presentation
Frontiers in Immunology, 2021 Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS).
Christian Münz
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Sec61 in antigen cross-presentation
Oncotarget, 2015 Upon recognition of antigens in the peripheral tissue, dendritic cells (DCs) migrate toward the draining lymph node to present internalized and processed antigens on major histocompatibility complex (MHC) molecules to T cells. In a process termed cross-presentation, antigen-derived peptides are presented on MHC I molecules to cytotoxic T cells.
Matthias, Zehner, Sven, Burgdorf
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