Results 271 to 280 of about 519,305 (288)

Dendritic Cells and HCMV Cross-Presentation

2003
The outcome of a viral infection is the result of an endless fight between the organism whose task is to mount an antiviral response and the virus that adapts strategies to circumvent the host response. Human cytomegalovirus (HCMV), a latent herpesvirus, can be considered as a spearhead in exploiting co-existence with the host to develop numerous ...
G, Arrode, C, Davrinche
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Coupled for Cross-Presentation in Tumor Immunotherapy

Science Translational Medicine, 2010
Bacterial infection–induced gap junctions in melanoma cells shuttle tumor antigens to immune cells and spur a successful antitumor immune response.
Baoxu, Pang, Jacques, Neefjes
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Cross-Presentation of Antigens by Dendritic Cells

Critical Reviews™ in Immunology, 2002
T lymphocytes recognize antigen presented on the surface of antigen-presenting cells byMHC class I and class II molecules. Classically, MHC class I molecules present self- or pathogen-derived antigens that are synthesized within the cell, whereas exogenous antigens derived via endocytic uptake are loaded onto MHC class II molecules for presentation to ...
Belz, Gabrielle T., Carbone, Francis R., Heath, William R.   +2 more
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Cross-presentation by human dendritic cell subsets

Immunology Letters, 2014
Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells. Several murine DC subsets differ in their phenotype and functional properties, in particular in their ability to cross-present antigens (i.e. to present exogenous antigens on their MHC class I molecules).
Elodie Segura, Sebastian Amigorena
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Cross-Presentation, Dendritic Cells, Tolerance and Immunity

Annual Review of Immunology, 2001
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or ...
W R, Heath, F R, Carbone
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Phagocytic neutrophils cross-present antigen

Blood, 2007
In this issue of Blood , Beauvillain and colleagues show that murine as well as human neutrophils are capable of cross-presenting exogenous antigens to CD8+ T cells. Neutrophils are the main inflammatory cells responsible for pathogen killing at sites of infection.
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Defining cross presentation for a wider audience

Current Opinion in Immunology, 2016
Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-dependent cross presentation pathway, but numerous pathways for transfer of antigenic material from a donor to a ...
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Designing Peptide Vaccines for Cellular Cross-Presentation

Biologicals, 2001
Synthetic peptides are safe and relatively cheap vaccine components. However, the efficiency of peptide vaccines is limited by peptide interaction with non-professional antigen-presenting cells, which may hamper induction of productive T-cell responses.
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Cross presentation from live cells

Molecular Immunology, 2022
Hatton, E.X., Isnard, S., Iannetta, M., Guillerme, J-B., Hosmalin, Anne   +4 more
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Elucidating Molecular Mechanisms of Cross-Presentation

Blood, 2015
The immune system regulates many processes vital to homeostasis. Antigen cross-presentation, an immune process specific to dendritic cells (DCs), critically contributes to maintaining homeostasis by regulating immune tolerance, antiviral activity, and antitumor responses.
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