Results 21 to 30 of about 505,675 (294)
Role of Immunoproteasomes in Cross-Presentation [PDF]
The Journal of Immunology, 2006 Abstract The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome ...
Palmowski, M +10 more
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Divergent Peptide Presentations of HLA-A*30 Alleles Revealed by Structures With Pathogen Peptides
Frontiers in Immunology, 2019 Human leukocyte antigen (HLA) alleles have a high degree of polymorphism, which determines their peptide-binding motifs and subsequent T-cell receptor recognition.
Shiyan Zhu +21 more
doaj +1 more source
Cross-presentation by dendritic cells
Nature Reviews Immunology, 2012 The presentation of exogenous antigens on MHC class I molecules, known as cross-presentation, is essential for the initiation of CD8(+) T cell responses. In vivo, cross-presentation is mainly carried out by specific dendritic cell (DC) subsets through an adaptation of their endocytic and phagocytic pathways.
Joffre, Olivier +3 more
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Current Concepts of Antigen Cross-Presentation [PDF]
Frontiers in Immunology, 2018 Dendritic cells have the ability to efficiently present internalized antigens on major histocompatibility complex (MHC) I molecules. This process is termed cross-presentation and is important role in the generation of an immune response against viruses and tumors, after vaccinations or in the induction of immune tolerance.
Maria Embgenbroich, Sven Burgdorf
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Shaping of T Cell Functions by Trogocytosis
Cells, 2021 Trogocytosis is an active process whereby plasma membrane proteins are transferred from one cell to the other cell in a cell-cell contact-dependent manner.
Masafumi Nakayama +3 more
doaj +1 more source
Into the Intracellular Logistics of Cross-Presentation [PDF]
Frontiers in Immunology, 2012 The induction of cytotoxic CD8(+) T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I). MHC I usually present peptides derived from endogenous proteins. However, some subtypes of dendritic cells have developed the ability to efficiently present peptides derived from exogenous antigens on MHC I via a process ...
Neefjes, Jacques, Sadaka, Charlotte
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Vaccines, 2023 This study found a higher percentage of CD8+ T cells in piglets immunized with a CVC1302-adjuvanted inactivated foot-and-mouth disease virus (FMDV) vaccine. We wondered whether the CVC1302-adjuvanted inactivated FMDV vaccine promoted cellular immunity by
Xiaoming Yu +11 more
doaj +1 more source
Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity
Frontiers in Oncology, 2014 Oncolytic viruses (OVs) are novel immunotherapeutic agents whose anticancer effects come from both oncolysis and elicited antitumor immunity. OVs induce mostly immunogenic cancer cell death (ICD), including immunogenic apoptosis, necrosis/necroptosis ...
Zong Sheng eGuo +2 more
doaj +1 more source
Frontiers in Immunology, 2021 We have reported that tumor-derived autophagosomes (DRibbles) were efficient carriers of tumor antigens and DRibbles antigens could be present by DRibbles-activated B cells to stimulate effect and naïve T cells in mice. However, the effect of DRibbles on
Hongyan Ren +6 more
doaj +1 more source
Pharmaceutics, 2019 Explosive growth in nanotechnology has merged with vaccine development in the battle against diseases caused by bacterial or viral infections and malignant tumors.
Cheol Gyun Kim +2 more
doaj +1 more source