Results 31 to 40 of about 505,675 (294)

Identification of a Potential Common Ancestor for Mammalian Cross-Presenting Dendritic Cells in Teleost Respiratory Surfaces

Frontiers in Immunology, 2018
Dendritic cells (DCs) are highly specialized antigen-presenting cells that bridge innate and adaptive immune responses in vertebrates, being key modulators in the initiation of specific responses.
Irene Soleto, Uwe Fischer, Carolina Tafalla, Aitor G. Granja   +3 more
doaj   +1 more source

Efficient Uptake of Recombinant Lipidated Survivin by Antigen-Presenting Cells Initiates Antigen Cross-Presentation and Antitumor Immunity

Frontiers in Immunology, 2018
Survivin is overexpressed in various types of human cancer, but rarely expressed in terminally differentiated adult tissues. Thus, survivin is a potential target antigen for a cancer vaccine.
Chen-Yi Chiang, Yi-Jyun Chen, Chiao-Chieh Wu, Shih-Jen Liu, Shih-Jen Liu, Chih-Hsiang Leng, Chih-Hsiang Leng, Hsin-Wei Chen, Hsin-Wei Chen   +8 more
doaj   +1 more source

Mining the Resource of Cross-Presentation [PDF]

Frontiers in Immunology, 2014
NA
openaire   +4 more sources

Cross-presentation: how to get there – or how to get the ER

Frontiers in Immunology, 2012
Antigen cross-presentation enables dendritic cells to present extracellular antigens on MHC I molecules, a process that plays an important role in the induction of immune responses against viruses and tumors and in the induction of peripheral tolerance ...
Christoph eKreer, Judith eRauen, Matthias eZehner, Sven eBurgdorf   +3 more
doaj   +1 more source

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations

Frontiers in Immunology, 2012
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection.
Edith M Janssen, Robert I Thacker
doaj   +1 more source

Vaccine-Induced CD8+ T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation

Frontiers in Immunology, 2020
Infections are most common and most severe at the extremes of age, the young and the elderly. Vaccination can be a key approach to enhance immunogenicity and protection against pathogens in these vulnerable populations, who have a functionally distinct ...
Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Elisabeth M. S. Beijnen, Simon D. van Haren, Simon D. van Haren   +4 more
doaj   +1 more source

Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells

Frontiers in Immunology, 2019
Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells.
Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert   +5 more
doaj   +1 more source

Chemokines: a new dendritic cell signal for T cell activation

Frontiers in Immunology, 2011
Dendritic cells (DCs) are the main inducers and regulators of cytotoxic T lymphocyte (CTL) responses against viruses and tumors. One checkpoint to avoid misguided CTL activation, which might damage healthy cells of the body, is the necessity for multiple
Christoph A Thaiss, Verena eSemmling, Lars eFranken, Hermann eWagner, Christian eKurts   +4 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

An updated view of the intracellular mechanisms regulating cross-presentation

Frontiers in Immunology, 2013
Cross-presentation involves the presentation of peptides derived from internalized cargo on major histocompatibility complex class I molecules by dendritic cells, a process critical for tolerance and immunity.
Julie Magarian eBlander, Priyanka eNair-Gupta   +1 more
doaj   +1 more source