Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators
Nature Communications, 2022 The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the ...
Purushotham Selvakumar +10 more
doaj +1 more source
Strain engineering in alloy nanoparticles
Advances in Physics: X, 2023 The deformation of interatomic distances with respect to those of the perfect crystal generates atomic-level strain. In nanoalloys, strain can arise because of finite size, morphology, domain structure and lattice mismatch between their atomic compounds.
Diana Nelli +2 more
doaj +1 more source
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. [PDF]
, 2019 Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin ...
Afonine +79 more
core +3 more sources
Structural visualization of key steps in human transcription initiation. [PDF]
, 2013 Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie +3 more
core +1 more source
A general perspective of the characterization and quantification of nanoparticles: Imaging, spectroscopic, and separation techniques [PDF]
, 2014 This article gives an overview of the different techniques used to identify, characterize, and quantify engineered nanoparticles (ENPs). The state-of-the-art of the field is summarized, and the different characterization techniques have been grouped ...
Anderson de la LLana, S. +10 more
core +3 more sources
Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]
, 2011 Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel +66 more
core +5 more sources
Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy
Acta Neuropathologica Communications, 2018 Nemaline myopathies are heterogeneous congenital muscle disorders causing skeletal muscle weakness and, in some cases, death soon after birth. Mutations in nebulin, encoding a large sarcomeric protein required for thin filament function, are responsible ...
Tamar E. Sztal +5 more
doaj +1 more source
A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization
Biomolecules, 2023 Viral entry and fertilization are distinct biological processes that share a common mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell membrane, triggering a series of conformational changes in the viral fusion proteins.
Farshad C. Azimi +5 more
doaj +1 more source
Microscale Fluid Behavior during Cryo-EM Sample Blotting [PDF]
, 2020 Blotting has been the standard technique for preparing aqueous samples for single-particle electron cryo-microscopy for over three decades. This technique removes the excess solution from a transmission electron microscope grid by pressing absorbent ...
Armstrong, Maxim +5 more
core +1 more source
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. [PDF]
, 2012 The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle-vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of ...
Brunger, Axel T +13 more
core +1 more source