Results 81 to 90 of about 714,192 (184)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

TLSB-03 THE MELANOMA CTC BRAIN-LIVER METASTASIS AXIS [PDF]

Neurooncol Adv
Melanoma brain metastasis (MBM) is linked to dismal prognosis and onset of brain metastasis is increasing in frequency in all cancer types. Circulating Tumor Cells (CTCs) are “seeds” of fatal metastasis and smallest functional units of cancer.
Dario Marchetti
europepmc   +2 more sources

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

SNSF Career Tracker Cohorts (CTC) Newsletter 2022/1 [PDF]

, 2022
This newsletter shows the first results of a longitudinal analysis of the CTC-18 cohort, which consists of people who applied for Early Postdoc.Mobility and Postdoc.Mobility in fall 2018.
Zimmermann, B., Kittelberger, S., Erzinger, A. B., Lüthi, J., Erzinger, A.B.   +4 more
core   +3 more sources

Natural Fish Trap‐Like Nanocage for Label‐Free Capture of Circulating Tumor Cells

Advanced Science, 2020
Nanomaterials have achieved several breakthroughs in the capture of circulating tumor cells (CTCs) over the past decades. However, artificial fabrication of label‐free nanomaterials used for high‐efficiency CTC capture is still a challenge.
Wenning Jiang, Lulu Han, Liwei Yang, Ting Xu, Jiabei He, Ruilian Peng, Ziyu Liu, Chong Zhang, Xiaomin Yu, Lingyun Jia   +9 more
doaj   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early-Stage Lung Cancers

, 2017
Early detection of metastasis can be aided by circulating tumor cells (CTC), which also show potential to predict early relapse. Because of the limited CTC numbers in peripheral blood in early stages, we investigated CTCs in pulmonary vein blood accessed
Shamileh Fouladdel, Lili Zhao, Max S. Wicha, Sunitha Nagrath, Nithya Ramnath, Zhuo Zhang, Philip Carrott, Ebrahim Azizi, Martin K. Ishikawa, Jules Lin, Andrew C. Chang, Svetlana Grabauskiene, Vasudha Murlidhar, Chandan Kumar-Sinha, Nallasivam Palanisamy, Rishindra M. Reddy, William R. Lynch, Mark B. Orringer, David G. Beer   +18 more
core   +3 more sources

Liquid biopsy across cancers: Integrating circulating biomarkers, tumor biology, artificial intelligence, and clinical translation

Interdisciplinary Medicine, EarlyView.
Liquid biopsy uses non‐invasive sampling of blood or body fluids to isolate circulating analytes, including circulating tumor DNA, circulating tumor cells, extracellular vesicles, and RNA. These are analyzed using next‐generation sequencing, qPCR, and proteomics to inform cancer detection, monitoring, and characterization. Figure created with BioRender.
Jaswinder Singh, Manjeet Kumar, Kajal Kamra   +2 more
wiley   +1 more source

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis

, 2014
SummaryCirculating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined.
Engstrom, Amanda, Yu, Min, Maheswaran, Shyamala, Ramaswamy, Sridhar, Shioda, Toshi, Bardia, Aditya, Zhu, Huili, Toner, Mehmet, Aceto, Nicola, Pely, Adam, Kapur, Ravi, Donaldson, Maria C., Lin, Charles P., Miyamoto, David T., Ting, David T., Brannigan, Brian W., Haber, Daniel A., Stott, Shannon L., Wittner, Ben S., Spencer, Joel A.   +19 more
core   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source