Results 211 to 220 of about 119,169 (307)

Myocarditis induced by a novel bifunctional PD-1/CTLA-4 combination antibody: a case report and literature review. [PDF]

BMC Cardiovasc Disord
Wei C, Tang C, Zhang Y, Tang Y, Liu Y, Tan Y, Fu Y.   +6 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Enterococcus faecalis KU-EF-004 enhances efficacy of anti-CTLA-4 immunotherapy for colorectal cancer via dendritic cell activation and gut microbiota modulation. [PDF]

BMC Immunol
Yamazaki T, Minami A, Kitagawa K, Yanase S, Ueki H, Shirakawa T.   +5 more
europepmc   +1 more source

Anti-CTLA-4 Monoclonal Antibody [PDF]

, 2020
openaire   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

CTLA-4-Ig therapy preserves cardiac function following myocardial infarction with reperfusion. [PDF]

Cardiovasc Res
Noonan J, Prijaya SA, Bienvenu LA, Dayawansa NH, Michla M, Bongcaron V, Sharma P, Song Y, Huang A, Barbaro-Wahl A, Huang Y, Nguyen H, Nguyen A, Murphy AJ, Zhang Y, Lee MKS, Johnson CJ, Watson AMD, Thomas AC, McFadyen JD, Donner DG, Wang X, Peter K.   +22 more
europepmc   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Extracellular vesicles released from melanoma cells constitutively expressing MHC class II promote immune evasion and cancer progression

The FEBS Journal, EarlyView.
Here, we report the role of extracellular vesicles (EVs) released from melanoma cells constitutively expressing MHC class II in the regulation of immune cell functions and melanoma metastasis. In particular, we observed an increased localization of HLA‐DRα, CAM receptors, PD‐L1, and STAT3 signaling proteins in the EVs.
Francesca Costantini, Caterina Di Sano, Samuele Raccosta, Mauro Manno, Giovanna Barbieri   +4 more
wiley   +1 more source

CTLA-4: Checkpoints beyond the membrane

Molecular Therapy
openaire   +2 more sources